Reference : Fatty acid efficiency profile in uncoupling of Acanthamoeba castellanii mitochondria.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Fatty acid efficiency profile in uncoupling of Acanthamoeba castellanii mitochondria.
Swida, A. [ > > ]
czarna, M. [ > > ]
Woyda-Polszczyca, A. [ > > ]
Kicinska, A. [ > > ]
Sluse, Francis mailto [Université de Liège - ULiège > Département des sciences de la vie > Bioénergétique et physiologie cellulaire >]
Jarmuszkiewicz, W. [ > > ]
Journal of Bioenergetics & Biomembranes
Kluwer Academic/Plenum Publishers
Yes (verified by ORBi)
New York
[en] fatty acids ; uncoupling ; uncoupling protein ; mitochondria ; Ancanthamoeba castellanii
[en] A profile of free fatty acid (FFA) specificity in Acanthamoeba castellanii mitochondrial uncoupling is described. The FFA uncoupling specificity was observed as different abilities to stimulate resting respiration, to decrease resting membrane potential, and to decrease oxidative phosphorylation efficiency. Tested unsaturated FFA (C18-20) were more effective as uncouplers and protonophores when compared to tested saturated FFA (C8-18), with palmitic acid (C16:0) as the most active. As FFA efficiency in mitochondrial uncoupling is related to physiological changes of fatty acid composition (and thereby FFA availability) during growth of amoeba cells, it could be a way to regulate the activity of an uncoupling protein and thereby the efficiency of oxidative phosphorylation during a cell life of this unicellular organism.

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