Article (Scientific journals)
Mitochondrial uncoupling proteins: new insights from functional and proteomic studies.
Douette, P.; Sluse, Francis
2006In Free Radical Biology and Medicine, 40, p. 1097-1107
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Keywords :
uncoupling protein; mitochondria; mitoproteome; proteomics; 2D-DIGE; free radical
Abstract :
[en] Mitochondria are the major sites of ATP synthesis through oxidative phosphorylation, a process that is weakened by proton leak. Uncoupling proteins are mitochondrial membrane proteins specialized in inducible proton conductance. They dissipate the proton electrochemical gradient established by the respiratory chain at the expense of reducing substrates. Several physiological roles have been suggested for uncoupling proteins, including roles in the control of the cellular energy balance and in preventive action against oxidative stress. This review focuses on new leads emerging from comparative proteomics about the involvement of uncoupling protein in the mitochondrial physiology. A brief overview on uncoupling proteins and on proteomics applied to mitochondria is also presented herein.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Douette, P.
Sluse, Francis ;  Université de Liège - ULiège > Département des sciences de la vie > Bioénergétique et physiologie cellulaire
Language :
English
Title :
Mitochondrial uncoupling proteins: new insights from functional and proteomic studies.
Publication date :
2006
Journal title :
Free Radical Biology and Medicine
ISSN :
0891-5849
eISSN :
1873-4596
Publisher :
Elsevier Science, Tarrytown, United States - New York
Volume :
40
Pages :
1097-1107
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 December 2009

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