Bisphenol A; Endocrine-disrupting chemicals; Photoperiod; Reproduction; Seasonality; Phodopus/physiology; Energy metabolism; Kisspeptin; Body Weight; Pollution; Public Health, Environmental and Occupational Health
Abstract :
[en] In nature, species synchronize reproduction and energy metabolism with seasons to optimize survival and growth. This study investigates the effect of oral exposure to bisphenol A (BPA) on phenotypic and neuroendocrine seasonal adaptations in the Djungarian hamster, which in contrast to conventional laboratory rodents, is a well-recognized seasonal model. Adult female and male hamsters were orally exposed to BPA (5, 50, or 500 μg/kg/d) or vehicle during a 10-week transition from a long (LP) to short (SP) photoperiod (winter transition) or vice versa (summer transition). Changes in body weight, food intake, and pelage color were monitored weekly and, at the end of the exposure, expression of hypophysio-hypothalamic markers of photoperiodic (TSHβ, deiodinases), reproductive (Rfrp, kisspeptin) and metabolic (somatostatin, Pomc) integration, reproductive organ activity, and glycemia were assessed. Our results revealed sex-specific effects of BPA on acquiring SP and LP phenotypes. During LP to SP transition, females exposed to 500 μg/kg/d BPA exhibited delayed body weight loss and reduced feed efficiency associated with a lower expression of somatostatin, while males exposed to 5 μg/kg/d BPA showed an accelerated acquisition of SP-induced metabolic parameters. During SP to LP transition, females exposed to 5 μg/kg/d BPA displayed a faster LP adaptation in reproductive and metabolic parameters, along with kisspeptin downregulation occurring 5 weeks earlier and Pomc upregulation delayed for up to 10 weeks. In males, BPA exposure led to decreased expression of central photoperiodic integrators, with no effect on the acquisition of the LP phenotype. This pioneering study investigating EDCs' effects on mammalian seasonal physiology shows that BPA alters the dynamics of metabolic adaptation to both SP and LP transitions with marked sex dimorphism, causing temporal discordance in seasonal adaptation between males and females. These findings emphasize the importance of investigating EDCs' effects on non-conventional animal models, providing insights into wildlife physiology.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Moralia, Marie-Azélie ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie ; Centre National de La Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, 8 Allée Du Général Rouvillois, 67000, Strasbourg, France
Bothorel, Béatrice; Centre National de La Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, 8 Allée Du Général Rouvillois, 67000, Strasbourg, France
Andry, Virginie; Centre National de La Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, 8 Allée Du Général Rouvillois, 67000, Strasbourg, France
Goumon, Yannick ; Centre National de La Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, 8 Allée Du Général Rouvillois, 67000, Strasbourg, France
Simonneaux, Valérie; Centre National de La Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, 8 Allée Du Général Rouvillois, 67000, Strasbourg, France. Electronic address: simonneaux@inci-cnrs.unistra.fr
Language :
English
Title :
Bisphenol A induces sex-dependent alterations in the neuroendocrine response of Djungarian hamsters to photoperiod.
This work was supported by the French agency for food, environmental and occupational health and safety (ANSES), the French Society for Endocrinology (SFE), and the Interdisciplinary Thematic Institute NeuroStra (ANR-10-IDEX-0002). We thank Dominique Ciocca, Sophie Reibel-Foisset, Nicolas Lethenet, and all the staff of the Chronobiotron animal facility of Strasbourg for taking care of the hamsters, as well as Paul Klosen for his guidance on the neuroanatomical analyses, and Sakina Mhaouty-Kodja for sharing her expertise on EDC research.This work was supported by the French agency for food, environmental and occupational health and safety (ANSES), the French Society for Endocrinology (SFE), and the Interdisciplinary Thematic Institute NeuroStra (ANR-10-IDEX-0002). We thank Dominique Ciocca, Sophie Reibel-Foisset, Nicolas Lethenet, and all the staff of the Chronobiotron\u2019s animal facility of Strasbourg for taking care of the hamsters, as well as Paul Klosen for his guidance on the neuroanatomical analyses.
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