Keywords :
callosal projection neuron; cerebral cortex; interneurons; neural development; neuronal plasticity; wiring; Animals; Mice; Corpus Callosum/cytology; Corpus Callosum/physiology; Interneurons/physiology; Nerve Net/cytology; Nerve Net/physiology; Neural Pathways/cytology; Neural Pathways/physiology; Neurons/physiology; Cerebral Cortex/cytology; Cerebral Cortex/physiology; Neural Inhibition/physiology; Corpus Callosum; Humans; Nerve Net; Neural Inhibition; Neural Pathways; Neurons; Neuroscience (all)
Abstract :
[en] The maturation of cerebral cortical networks during early life involves a major reorganization of long-range axonal connections. In a recent study, Bragg-Gonzalo, Aguilera, et al. discovered that in mice, the interhemispheric connections sent by S1L4 callosal projection neurons are pruned via the tight control of their ipsilateral synaptic integration, which relies on the early activity of specific interneurons.
Funding text :
The work performed in the Nguyen laboratory is supported by ULi\u00E8ge (Cr\u00E9dit Classique), the F.R.S.-F.N.R.S. (PDR T.0185.20; EOS 0019118F-RG36), WELBIO (CR-2022A-12), the Fonds Leon Fredericq, the Fondation Simone et Pierre Clerdent, the ERANET Neuron (STEM-MCD and NeuroTalk), the Win2Wal (ChipOmics; #2010126), and the ERC-Synergy (UNFOLD). The authors have no competing interest in relation to this work.The work performed in the Nguyen laboratory is supported by ULi\u00E8ge (Cr\u00E9dit Classique), the F.R.S.- F.N.R.S. ( PDR T.0185.20 ; EOS 0019118F-RG36 ), WELBIO ( CR-2022A-12 ), the Fonds Leon Fredericq , the Fondation Simone et Pierre Clerdent , the ERANET Neuron (STEM-MCD and NeuroTalk), the Win2Wal (ChipOmics; #2010126 ), and the ERC-Synergy (UNFOLD).
Scopus citations®
without self-citations
0
