The nucleoporin Nup153 is the anchor for Kif1a during basal nuclear migration in brain progenitor cells

brain development; cell cycle regulation; CP: Cell biology; CP: Neuroscience; interkinetic nuclear migration; Kif1a; neuronal migration; Nup153; Animals; Brain; Cell Nucleus; Humans; Kinesins; Mice; Nuclear Pore Complex Proteins; Stem Cells; bupivacaine; buprenorphine; cyclin D1; cytoplasmic dynein; hemagglutinin; ketamine; nucleoporin; small interfering RNA; kinesin; adipose derived stem cell; adult; animal cell; animal experiment; animal model; animal tissue; Article; carboxy terminal sequence; cell cycle progression; cell division; cell structure; clinical article; controlled study; electroporation; glioma; human; human cell; human tissue; immunoblotting; immunohistochemistry; migration; mouse; nerve cell; nonhuman; progenitor cell line; rat; stem cell; Western blotting; animal; brain; cell nucleus; cytology; genetics; metabolism

Abstract :

[en] Radial glial progenitors (RGPs) are highly elongated epithelial cells that give rise to most stem cells, neurons, and glia in the vertebrate cerebral cortex. During development, the RGP nuclei exhibit a striking pattern of cell-cycle-dependent oscillatory movements known as interkinetic nuclear migration (INM), which we previously found to be mediated during G1 by the kinesin Kif1a and during G2 by cytoplasmic dynein, recruited to the nuclear envelope by the nucleoporins RanBP2 and Nup133. We now identify Nup153 as a nucleoporin anchor for Kif1a, responsible for G1-specific basal nuclear migration, providing a complete model for the mechanisms underlying this basic but mysterious behavior, with broad implications for understanding brain development. © 2024 The Authors

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Falnikar, A.; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, 10032, NY, United States

Quintremil, S.; Institute of Brain Science, College of Medicine, National Yang Ming Chiao Tung University, 112, Taipei, Taiwan

Zhao, H.-J.

Cheng, Haw-Yuan ; Université de Liège - ULiège > GIGA > GIGA Neurosciences - Molecular Regulation of Neurogenesis ; Institute of Brain Science, College of Medicine, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan

Helmer, P.

Tsai, J.-W.

Vallee, R.B.

Language :

English

Title :

The nucleoporin Nup153 is the anchor for Kif1a during basal nuclear migration in brain progenitor cells

Publication date :

2024

Journal title :

Cell Reports

eISSN :

2211-1247

Publisher :

Elsevier

Volume :

Issue :

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85211472368&doi=10.1016%2fj.celrep.2024.115008&partnerID=40&md5=f5f3072804d2407e27b2eb389bfbf161

Available on ORBi :

since 14 April 2025

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