[en] [en] PURPOSE: High consumption of ultra-processed food (UPF) is associated with an increased risk of developing chronic diseases. Inflammation may be one of the underlying mechanisms behind this association. However, only a limited number of studies have investigated the association between UPF consumption and a few selected inflammation biomarkers, yielding inconsistent results. This study aimed to assess the cross-sectional association between UPF consumption (as a whole and 10 sub-categories), and 78 circulating proteins related to inflammation.
METHODS: The present study included 1594 adult participants from the STANISLAS cohort. UPF consumption was estimated using the NOVA classification, and linear regression models were used to assess their association with circulating proteins.
RESULTS: UPFs accounted for 28% of the total energy intake and 5.7 servings on average per day. In the unadjusted model, 15 circulating proteins had a significant association with UPF consumption. After adjustment, only (FGF-19) was significantly associated with UPF consumption (β = - 0.02[- 0.03; - 0.003]).
CONCLUSION: UPF consumption was negatively associated with Fibroblast Growth Factor 19 (FGF-19) serum levels. When considering UPF sub-categories, no circulating proteins were associated with dairy products and dairy desserts. Of note, circulating proteins were differentially associated depending on the sub-category of UPF. Further studies are needed to better understand the link between UPF and inflammation.
Disciplines :
Public health, health care sciences & services
Author, co-author :
Xia, Lea Lin Chun Hu; Centre d'Investigation Clinique-Plurithématique, Inserm CIC-P 1433, Pierre Drouin, INSERM, CHRU de Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Institut Lorrain du Coeur Et Des Vaisseaux Louis Mathieu, Université de Lorraine, 4 Rue du Morvan, 54500, Vandoeuvre-Lès-Nancy, France
Girerd, Nicolas; Centre d'Investigation Clinique-Plurithématique, Inserm CIC-P 1433, Pierre Drouin, INSERM, CHRU de Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Institut Lorrain du Coeur Et Des Vaisseaux Louis Mathieu, Université de Lorraine, 4 Rue du Morvan, 54500, Vandoeuvre-Lès-Nancy, France. n.girerd@chru-nancy.fr
Lamiral, Zohra; Centre d'Investigation Clinique-Plurithématique, Inserm CIC-P 1433, Pierre Drouin, INSERM, CHRU de Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Institut Lorrain du Coeur Et Des Vaisseaux Louis Mathieu, Université de Lorraine, 4 Rue du Morvan, 54500, Vandoeuvre-Lès-Nancy, France
Duarte, Kevin; Centre d'Investigation Clinique-Plurithématique, Inserm CIC-P 1433, Pierre Drouin, INSERM, CHRU de Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Institut Lorrain du Coeur Et Des Vaisseaux Louis Mathieu, Université de Lorraine, 4 Rue du Morvan, 54500, Vandoeuvre-Lès-Nancy, France
Merckle, Ludovic; Centre d'Investigation Clinique-Plurithématique, Inserm CIC-P 1433, Pierre Drouin, INSERM, CHRU de Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Institut Lorrain du Coeur Et Des Vaisseaux Louis Mathieu, Université de Lorraine, 4 Rue du Morvan, 54500, Vandoeuvre-Lès-Nancy, France
Leroy, Celine; Centre d'Investigation Clinique-Plurithématique, Inserm CIC-P 1433, Pierre Drouin, INSERM, CHRU de Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Institut Lorrain du Coeur Et Des Vaisseaux Louis Mathieu, Université de Lorraine, 4 Rue du Morvan, 54500, Vandoeuvre-Lès-Nancy, France
Nazare, Julie-Anne; Centre de Recherche en Nutrition Humaine Rhône-Alpes, Hospices Civils de Lyon, F-CRIN/FORCE Network, Univ-Lyon, CarMeN Laboratory, Université Claude Bernard Lyon1, Lyon, France
Van Den Berghe, Laurie; Centre de Recherche en Nutrition Humaine Rhône-Alpes, Hospices Civils de Lyon, F-CRIN/FORCE Network, Univ-Lyon, CarMeN Laboratory, Université Claude Bernard Lyon1, Lyon, France
Seconda, Louise; Centre de Recherche en Nutrition Humaine Rhône-Alpes, Hospices Civils de Lyon, F-CRIN/FORCE Network, Univ-Lyon, CarMeN Laboratory, Université Claude Bernard Lyon1, Lyon, France
Hoge, Axelle ; Université de Liège - ULiège > Département des sciences de la santé publique
Guillaume, Michèle ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique : aspects spécifiques
Laville, Martine; Centre de Recherche en Nutrition Humaine Rhône-Alpes, Hospices Civils de Lyon, F-CRIN/FORCE Network, Univ-Lyon, CarMeN Laboratory, Université Claude Bernard Lyon1, Lyon, France
Rossignol, Patrick; Centre d'Investigation Clinique-Plurithématique, Inserm CIC-P 1433, Pierre Drouin, INSERM, CHRU de Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Institut Lorrain du Coeur Et Des Vaisseaux Louis Mathieu, Université de Lorraine, 4 Rue du Morvan, 54500, Vandoeuvre-Lès-Nancy, France ; Medicine and Nephrology-Dialysis Departments, Princess Grace Hospital, Monaco Private Hemodialysis Centre, Monaco, Monaco ; M-CRIN, (Monaco Clinical Research Infrastructure Network), Monaco, France
Boivin, Jean-Marc; Centre d'Investigation Clinique-Plurithématique, Inserm CIC-P 1433, Pierre Drouin, INSERM, CHRU de Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Institut Lorrain du Coeur Et Des Vaisseaux Louis Mathieu, Université de Lorraine, 4 Rue du Morvan, 54500, Vandoeuvre-Lès-Nancy, France ; Department of General Medicine, University of Lorraine, Vandoeuvre-Lès-Nancy, France
Wagner, Sandra ; Centre d'Investigation Clinique-Plurithématique, Inserm CIC-P 1433, Pierre Drouin, INSERM, CHRU de Nancy Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Institut Lorrain du Coeur Et Des Vaisseaux Louis Mathieu, Université de Lorraine, 4 Rue du Morvan, 54500, Vandoeuvre-Lès-Nancy, France
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