electrospray; internal energy; heated capillary; pressure effect; mass spectrometry
Abstract :
[en] The internal energy distributions in a heated capillary nano-electrospray source have been determined using the "survival yield" method. At low capillary temperatures, the internal energy distribution is characterized by a low-energy tail, which can be attributed to a fraction of ions not fully desolvated in the heated capillary. This low-energy tais is shown to disappear when the source pressure is increased. This explains why increased source pressure is favorable in the case of highly hydrophilic compounds or non-covalent complexes in order to achieve sufficient desolvation without fragmentation. It is also shown that "high temperature-low voltage" are not equivalent to "low temperature-high voltage" source conditions. These observations are important for fundamental issues as well as for source-CID mass spectral library searching applications.
Research Center/Unit :
CART - Centre Interfacultaire d'Analyse des Résidus en Traces - ULiège
Disciplines :
Chemistry
Author, co-author :
Gabelica, Valérie ; Université de Liège - ULiège > Département de Chimie (Sciences) > Chimie physique, spectrométrie de masse
De Pauw, Edwin ; Université de Liège - ULiège > Département de Chimie (Sciences) > Chimie physique, spectrométrie de masse
Karas, Michael; Institüt für Pharmazeutische Chemie, Johann-Wolfgang Goethe Universität Frankfurt, Marie-Curie Strasse 9-11, D-60439 Frankfurt am Main, Germany
Language :
English
Title :
Influence of the capillary temperature and the source pressure on the internal energy distribution of electrosprayed ions
Publication date :
2004
Journal title :
International Journal of Mass Spectrometry
ISSN :
1387-3806
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
231
Issue :
2-3
Pages :
189-195
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique AvH - Alexander von Humboldt-Stiftung
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