[en] In June 2005, a World Health Organization (WHO)-International Programme on Chemical Safety expert meeting was held in Geneva during which the toxic equivalency factors (TEFs) for dioxin-like compounds, including some polychlorinated biphenyls (PCBs), were reevaluated. For this reevaluation process, the refined TEF database recently published by Haws et al. (2006, Toxicol. Sci. 89, 4-30) was used as a starting point. Decisions about a TEF value were made based on a combination of unweighted relative effect potency (REP) distributions from this database, expert judgment, and point estimates. Previous TEFs were assigned in increments of 0.01, 0.05, 0.1, etc., but for this reevaluation, it was decided to use half order of magnitude increments on a logarithmic scale of 0.03, 0.1, 0.3, etc. Changes were decided by the expert panel for 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) (TEF = 0.3), 1,2,3,7,8-pentachlorodibenzofuran (PeCDF) (TEF = 0.03), octachlorodibenzo-p-dioxin and octachlorodibenzofuran (TEFs = 0.0003), 3,4,4',5-tetrachlorbiphenyl (PCB 81) (TEF = 0.0003), 3,3',4,4',5,5'-hexachlorobiphenyl (PCB 169) (TEF = 0.03), and a single TEF value (0.00003) for all relevant mono-ortho-substituted PCBs. Additivity, an important prerequisite of the TEF concept was again confirmed by results from recent in vivo mixture studies. Some experimental evidence shows that non-dioxin-like aryl hydrocarbon receptor agonists/antagonists are able to impact the overall toxic potency of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds, and this needs to be investigated further. Certain individual and groups of compounds were identified for possible future inclusion in the TEF concept, including 3,4,4'-TCB (PCB 37), polybrominated dibenzo-p-dioxins and dibenzofurans, mixed polyhalogenated dibenzo-p-dioxins and dibenzofurans, polyhalogenated naphthalenes, and polybrominated biphenyls. Concern was expressed about direct application of the TEF/total toxic equivalency (TEQ) approach to abiotic matrices, such as soil, sediment, etc., for direct application in human risk assessment. This is problematic as the present TEF scheme and TEQ methodology are primarily intended for estimating exposure and risks via oral ingestion (e.g., by dietary intake). A number of future approaches to determine alternative or additional TEFs were also identified. These included the use of a probabilistic methodology to determine TEFs that better describe the associated levels of uncertainty and "systemic" TEFs for blood and adipose tissue and TEQ for body burden.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Van den Berg, Martin; World Health Organization Collaborating Centre for Research on Environmental Health Risk Assessment and Institute for Risk Assessment Sciences, Science and University Medical Center, Universiteit Utrecht, The Netherlands. m.vandenberg@iras.uu.nl
Birnbaum, Linda S; National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency Research, Triangle Park, NC 27709, United States
Denison, Michael; Department of Environmental Toxicology, University of California at Davis, Davis, CA 95616-8501, United States
De Vito, Mike; National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency Research, Triangle Park, NC 27709, United States
Farland, William; Office of Research and Development, U.S. Environmental Protection Agency (EPA), Washington, DC 20460, United States
Feeley, Mark; Chemical Health Hazard Assessment Division, Bureau of Chemical Safety, Health Canada, Ottawa, ON K1A 0L2, Canada
Fiedler, Heidelore ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique, organique et biologique ; United Nations Environment Program Chemicals, International Environment House, CH-1219 Châtelaine GE, Switzerland
Hakansson, Helen; Institute of Environmental Medicine, Karolinska Institutet, Unit of Environmental Health Risk Assessment, S-171 77 Stockholm, Sweden
Hanberg, Annika; Institute of Environmental Medicine, Karolinska Institutet, Unit of Environmental Health Risk Assessment, S-171 77 Stockholm, Sweden
Haws, Laurie; ChemRisk, Austin, TX, United States
Rose, Martin; Central Science Laboratory, YO41 1LZ York, United Kingdom
Safe, Stephen; Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843-4466, United States
Schrenk, Dieter; Department of Food Chemistry and Environmental Toxicology, University of Kaiserslautern, Kaiserslautern 67663, Germany
Tohyama, Chiharu; Division of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan
Tritscher, Angelika; International Programme on Chemical Safety, World Health Organization, 1211 Geneva 27, Switzerland
Tuomisto, Jouko; National Public Health Institute, Department of Environmental Health, FI-70701 Kuopio, Finland
Tysklind, Mats; Environmental Chemistry, Umeå University, Umeå SE-901 87, Sweden
Walker, Nigel; National Institute of Environmental Health Sciences Research, Triangle Park, NC 27709, United States
Peterson, Richard E; School of Pharmacy and Molecular, Environmental Toxicology Center, University of Wisconsin, Madison, WI 53705, United States
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