Article (Scientific journals)
Multicenter Belgian prospective registry on minimally invasive and open liver surgery (BReLLS): experience from 1342 consecutive cases.
Troisi, Roberto Ivan; Rompianesi, Gianluca; D'Hondt, Mathieu et al.
2025In Langenbeck's Archives of Surgery, 410 (1), p. 86
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Keywords :
Laparoscopic surgery; Liver surgery; Minimally invasive surgery; Open surgery; Outcomes; Humans; Male; Female; Middle Aged; Prospective Studies; Aged; Belgium; Postoperative Complications/epidemiology; Postoperative Complications/etiology; Adult; Liver Neoplasms/surgery; Liver Neoplasms/mortality; Liver Neoplasms/pathology; Length of Stay/statistics & numerical data; Liver Diseases/surgery; Treatment Outcome; Hepatectomy/methods; Registries; Minimally Invasive Surgical Procedures/methods; liver transplantation; cancer
Abstract :
[en] [en] PURPOSE: Minimally invasive liver surgery (MILS) still appears to be adopted with significant variability. We aimed to investigate the diffusion, indications, and short-term outcomes of MILS compared to the open approach. METHODS: A prospective registry of all liver resections performed for any indication and using any technique between January 1, 2017, and December 31, 2019, was established (BReLLS) and analyzed. RESULTS: A total of 1342 consecutive liver resections were included, 684 (51%) MILS and 658 (49%) open procedures. MILS was not attempted due to technical complexity in the 46.2% of cases, followed by previous abdominal surgery (22.5%). Patients undergoing MILS had a higher proportion of benign indications and of hepatocellular carcinomas, patients affected by liver cirrhosis with portal hypertension and a lower proportion of major hepatectomies (all p < 0.001). After propensity-score matching, MILS showed better results in terms of surgery duration (p < 0.001), blood loss (p = 0.015), complication rate (p < 0.001), rate of Clavien-Dindo grade ≥ 3 complications (p = 0.012), comprehensive complication index (p < 0.001), length of stay (p < 0.001), readmissions (p = 0.016). Centers performing over 50 liver resections per year had a higher proportion of overall MILS cases (p < 0.001), a similar proportion of major resections (p = 0.362), but a higher prevalence of MILS major resections (p = 0.004), lower 90-day mortality rates (p < 0.001), lower overall complication rates (p < 0.001), and shorter hospital length of stay (p < 0.001). CONCLUSION: MILS was the preferred technique in half of the cases, particularly in patients with cirrhosis and portal hypertension, and benign lesions. It provided superior short-term outcomes compared to the open approach for both minor and major liver resections in selected patients.
Disciplines :
Surgery
Oncology
Author, co-author :
Troisi, Roberto Ivan;  Faculty of Medicine, Ghent University, Ghent, Belgium. roberto.troisi@unina.it ; Federico II University Hospital, via S. Pansini 5, 80131, Naples, Italy. roberto.troisi@unina.it
Rompianesi, Gianluca;  Federico II University Hospital, via S. Pansini 5, 80131, Naples, Italy
D'Hondt, Mathieu;  AZ Groeninge Kortrijk, Kortrijk, Belgium
Vanlander, Aude;  VUB Jette Brussels, Jette, Belgium
Bertrand, Claude;  CHU-UCL Namur - site Mont Godinne, Yvoir, Belgium
Hubert, Catherine;  UCL - Saint Luc- Brussels, Brussels, Belgium
Detry, Olivier  ;  Université de Liège - ULiège > Département des sciences cliniques > Pathologie chirurgicale abdominale et endocrinienne
Van den Bossche, Bert;  ASZ Aalst, Aalst, Belgium
Malvaux, Philippe;  Centre Hospitalier de Wallonie Picard site Notre-Dame, Tournai, Belgium
Weerts, Joseph;  Clinique Saint-Joseph, Liege, Belgium
Sablon, Thibault;  VITAZ Sint-Niklaas, Sint-Niklaas, Belgium
Vermeiren, Koen;  Imelda Ziekenhuis, Bonheiden, Belgium
Biglari, Mehrdad;  Sint-Andries Ziekenhuis, Tielt, Belgium
Gryspeerdt, Filip;  Heilig Hart Ziekenhuis, Liers, Belgium
De Meyere, Celine;  AZ Groeninge Kortrijk, Kortrijk, Belgium
Dili, Alexandra;  CHU-UCL Namur - site Mont Godinne, Yvoir, Belgium
Boterbergh, Kim;  ASZ Aalst, Aalst, Belgium
Lucidi, Valerio;  Universite Libre de Bruxelles- Erasme Hospital, Brussels, Belgium
More authors (8 more) Less
Language :
English
Title :
Multicenter Belgian prospective registry on minimally invasive and open liver surgery (BReLLS): experience from 1342 consecutive cases.
Publication date :
03 March 2025
Journal title :
Langenbeck's Archives of Surgery
ISSN :
1435-2443
eISSN :
1435-2451
Publisher :
Springer Science and Business Media LLC, Germany
Volume :
410
Issue :
1
Pages :
86
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Università degli Studi di Napoli Federico II
Available on ORBi :
since 04 March 2025

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