Vitamins; Vitamin D; 25-hydroxyvitamin D; Calcifediol; Humans; Vitamin D/analogs & derivatives; Melanoma/pathology; Skin Neoplasms/pathology; body mass index; melanoma; Skin Neoplasms; Dermatology; General Medicine
Abstract :
[en] Vitamin D status is influenced by well-known determinants, but factors associated with low 25-hydroxyvitamin D levels in the cutaneous melanoma population are not well defined. The aim of this study was to confirm the well-known determinants and to assess new determinants for 25-hydroxyvitamin D levels in a cutaneous melanoma population. In a prospectively included cohort of 387 patients with cutaneous melanoma the association of 25-hydroxyvitamin D levels with sex, age, body mass index, time of blood withdrawal, Fitzpatrick phototype, vitamin D supplementation, score for intensity of lifetime sun exposure, smoking, education level, hair and skin colour, eye colour, total number of benign naevi, freckles and parameters of chronic sun damage was investigated. In addition, 25-hydroxyvitamin D levels were correlated with pathological parameters of the primary tumour and melanoma stage (8th edition of the American Joint Committee on Cancer (AJCC). Univariate and multivariate logistic regressions were performed using R software. The following factors had a significant effect on vitamin D status: body mass index, seasonal time of blood sampling, vitamin D supplementation, and a subtype of skin, and hair colour.
Disciplines :
Dermatology
Author, co-author :
De Smedt, Julie; School of Biomedical sciences, Department of Oncology, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium. julie.desmedt@uzleuven.be
Van Kelst, Sofie; Laboratory of Dermatology, Department of oncology, KU Leuven, Leuven, Belgium
Janssen, Laudine; Laboratory of Dermatology, Department of oncology, KU Leuven, Leuven, Belgium
Marasigan, Vivien; Laboratory of Dermatology, Department of oncology, KU Leuven, Leuven, Belgium ; Department of Surgery, South Infirmary Victoria University Hospital, Cork, Ireland
Boecxstaens, Veerle; Oncological and vascular access surgery, Department of Surgical Oncology, KU Leuven, Leuven, Belgium
Stas, Marguerite; Oncological and vascular access surgery, Department of Surgical Oncology, KU Leuven, Leuven, Belgium
Vanderschueren, Dirk; Clinical and experimental Endocrinology, Department Chronical illness and Metabolism, KU Leuven, Leuven, Belgium
Guler, Ipek; Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat), KU Leuven, Leuven, Belgium
Bogaerts, Kris; Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat), KU Leuven, Leuven, Belgium
Vandenberghe, Katleen; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
Bechter, Oliver; Laboratory of Experimental Oncology (LEO), Department of Oncology, KU Leuven, Leuven, Belgium
Billen, Jaak; Clinical and Experimental Endocrinology, Department of Chronic Diseases, KU Leuven, Leuven, Belgium
Nikkels, Arjen ; Centre Hospitalier Universitaire de Liège - CHU > > Service de dermatologie
Strobbe, Tine; Department of Dermatology, Imelda ziekenhuis, Bonheiden, Belgium
Emri, Gabriella; Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Lambrechts, Diether; Laboratory for Translational Genetics, Department of Oncology, KU Leuven, Leuven, Belgium ; Center for cancer Biology (VIB), Leuven, Belgium
Garmyn, Marjan; Laboratory of Dermatology, Department of oncology, KU Leuven, Leuven, Belgium
This research project was funded by Kom op tegen Kanker (Stand up to Cancer), the Flemish cancer society, Anticanderfunds, and agency for Innovation by science and technology (IWT) – applied biomedical research program (TBM).
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