Early versus delayed cranioplasty after decompressive craniectomy in traumatic brain injury: a multicenter observational study within CENTER-TBI and Net-QuRe.

Vreeburg, Rick J G; Singh, Ranjit D; van Erp, Inge A M; Korhonen, Tommi K; Yue, John K; Mee, Harry; Timofeev, Ivan; Kolias, Angelos; Helmy, Adel; Depreitere, Bart; Moojen, Wouter A; Younsi, Alexander; Hutchinson, Peter; Manley, Geoffrey T; Steyerberg, Ewout W; de Ruiter, Godard C W; Maas, Andrew I R; Peul, Wilco C; van Dijck, Jeroen T J M; den Boogert, Hugo F; Posti, Jussi P; van Essen, Thomas A; for the CENTER-TBI Participants and Investigators

doi:10.3171/2024.1.JNS232172

Article (Scientific journals)

Early versus delayed cranioplasty after decompressive craniectomy in traumatic brain injury: a multicenter observational study within CENTER-TBI and Net-QuRe.

Vreeburg, Rick J G; Singh, Ranjit D; van Erp, Inge A M et al.

2024 • In Journal of Neurosurgery, 141 (4), p. 895 - 907

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/328401

DOI
10.3171/2024.1.JNS232172

PubMed
38669706

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Keywords :

complication; cranioplasty; delayed; early; timing; trauma; traumatic brain injury; Humans; Male; Female; Middle Aged; Adult; Prospective Studies; Treatment Outcome; Aged; Plastic Surgery Procedures/methods; Cohort Studies; Time Factors; Registries; Time-to-Treatment; Decompressive Craniectomy/methods; Brain Injuries, Traumatic/surgery; Brain Injuries, Traumatic/complications; Quality of Life; Brain Injuries, Traumatic; Decompressive Craniectomy; Plastic Surgery Procedures; Surgery; Neurology (clinical)

Abstract :

[en] [en] OBJECTIVE: The aim of this study was to compare the outcomes of early (≤ 90 days) and delayed (> 90 days) cranioplasty following decompressive craniectomy (DC) in patients with traumatic brain injury (TBI). METHODS: The authors analyzed participants enrolled in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) and the Neurotraumatology Quality Registry (Net-QuRe) studies who were diagnosed with TBI and underwent DC and subsequent cranioplasty. These prospective, multicenter, observational cohort studies included 5091 patients enrolled from 2014 to 2020. The effect of cranioplasty timing on functional outcome was evaluated with multivariable ordinal regression and with propensity score matching (PSM) in a sensitivity analysis of functional outcome (Glasgow Outcome Scale-Extended [GOSE] score) and quality of life (Quality of Life After Brain Injury [QOLIBRI] instrument) at 12 months following DC. RESULTS: Among 173 eligible patients, 73 (42%) underwent early cranioplasty and 100 (58%) underwent delayed cranioplasty. In the ordinal logistic regression and PSM, similar 12-month GOSE scores were found between the two groups (adjusted odds ratio [aOR] 0.87, 95% CI 0.61-1.21 and 0.88, 95% CI 0.48-1.65, respectively). In the ordinal logistic regression, early cranioplasty was associated with a higher risk for hydrocephalus than that with delayed cranioplasty (aOR 4.0, 95% CI 1.2-16). Postdischarge seizure rates (early cranioplasty: aOR 1.73, 95% CI 0.7-4.7) and QOLIBRI scores (β -1.9, 95% CI -9.1 to 9.6) were similar between the two groups. CONCLUSIONS: Functional outcome and quality of life were similar between early and delayed cranioplasty in patients who had undergone DC for TBI. Neurosurgeons may consider performing cranioplasty during the index admission (early) to simplify the patient's chain of care and prevent readmission for cranioplasty but should be vigilant for an increased possibility of hydrocephalus. Clinical trial registration nos.: CENTER-TBI, NCT02210221 (clinicaltrials.gov); Net-QuRe, NTR6003 (trialsearch.who.int) and NL5761 (onderzoekmetmensen.nl).

Disciplines :

Anesthesia & intensive care

Author, co-author :

Vreeburg, Rick J G; 1University Neurosurgical Center Holland, Leiden University Medical Center, Haaglanden Medical Center and Haga Teaching Hospital, Leiden and The Hague, The Netherlands

Singh, Ranjit D; 1University Neurosurgical Center Holland, Leiden University Medical Center, Haaglanden Medical Center and Haga Teaching Hospital, Leiden and The Hague, The Netherlands

van Erp, Inge A M; 1University Neurosurgical Center Holland, Leiden University Medical Center, Haaglanden Medical Center and Haga Teaching Hospital, Leiden and The Hague, The Netherlands

Korhonen, Tommi K; 2Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge and Addenbrooke's Hospital, Cambridge, United Kingdom ; 3Neurocenter, Department of Neurosurgery and Research Unit of Clinical Neuroscience, Neurosurgery, Oulu University Hospital and University of Oulu, Finland

Yue, John K; 4Department of Neurosurgery, University of California, San Francisco, California

Mee, Harry; 2Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge and Addenbrooke's Hospital, Cambridge, United Kingdom

Timofeev, Ivan; 2Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge and Addenbrooke's Hospital, Cambridge, United Kingdom

Kolias, Angelos; 2Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge and Addenbrooke's Hospital, Cambridge, United Kingdom

Helmy, Adel; 2Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge and Addenbrooke's Hospital, Cambridge, United Kingdom

Depreitere, Bart; 5Department of Neurosurgery, University Hospital Leuven, Belgium

More authors (13 more)

Other collaborator :

Ledoux, Didier ; Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs généraux

Language :

English

Title :

Early versus delayed cranioplasty after decompressive craniectomy in traumatic brain injury: a multicenter observational study within CENTER-TBI and Net-QuRe.

Publication date :

01 October 2024

Journal title :

Journal of Neurosurgery

ISSN :

0022-3085

eISSN :

1933-0693

Publisher :

American Association of Neurological Surgeons, United States

Volume :

141

Issue :

Pages :

895 - 907

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://thejns.org/view/journals/j-neurosurg/141/4/article-p895.xml

Funding text :

her editorial support and all CENTER-TBI participants and investigators. CENTER-TBI was supported by the European Union 7th Framework Programme for Research (grant no. 602150; A.I.R.M.), Hannelore Kohl Stiftung (Germany), and OneMind (United States). Net-QuRe was supported by the Hersenstichting Nederland (Dutch Brain Foundation, grant no. ps2014.06). Dr. Korhonen reported research grants from the Finnish Cultural Foundation, Finnish Medical Foundation, and Orion Research Foundation outside the submitted work. Dr. Yue reported grants from the Neurosurgery Research and Education Foundation and Bagan Family Foundation Research Fellowship (award no. A139203, to the University of California, San Francisco) outside the submitted work. Dr. Maas reported grants from the European Union 7th Framework Programme for Research during the conduct of the study. Dr. Peul reported grants from European Committee Grant CENTER-TBI and grants from the Netherlands Brain Foundation during the conduct of the study. Dr. Posti reported funding from the Academy of Finland (grant no. 17379) and the Maire Taponen Foundation. Dr. van Essen reported grants from the European Union 7th Framework Programme for Research or CENTER-TBI and Hersenstichting Nederland (Dutch Brain Foundation) for Net-QuRe and the Niels Stensen Fellowship during the conduct of the study. Dr. Hutchinson is supported by the National Institute for Health and Care Research (Cambridge BRC, Brain Injury Medtech Co-operative, Global Health Research Group on Acquired Brain and Spine Injury, Senior Investigator Award) and the Royal College of Surgeons of England. The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report.

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Bibliography

Traumatisch hersenletsel (THL) zorgstandaard. Zorginstituut Nederland. Accessed February 15, 2024. https://www.zorginzicht.nl/kwaliteitsinstrumenten/traumatischhersenletsel-thl-zorgstandaard
Brazinova A, Rehorcikova V, Taylor MS, et al. Epidemiology of traumatic brain injury in Europe: a living systematic review. J Neurotrauma. 2021;38(10):1411-1440.
GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators. Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18(1):56-87.
Hutchinson PJ, Adams H, Mohan M, et al. Decompressive craniectomy versus craniotomy for acute subdural hematoma. N Engl J Med. 2023;388(24):2219-2229.
Cooper DJ, Rosenfeld JV, Murray L, et al. Decompressive craniectomy in diffuse traumatic brain injury. N Engl J Med. 2011;364(16):1493-1502.
Hutchinson PJ, Kolias AG, Timofeev IS, et al. Trial of decompressive craniectomy for traumatic intracranial hypertension. N Engl J Med. 2016;375(12):1119-1130.
Kunze E, Meixensberger J, Janka M, Sörensen N, Roosen K. Decompressive craniectomy in patients with uncontrollable intracranial hypertension. Acta Neurochir Suppl. 1998;71:16-18.
Schneider GH, Bardt T, Lanksch WR, Unterberg A. Decompressive craniectomy following traumatic brain injury: ICP, CPP and neurological outcome. Acta Neurochir Suppl. 2002;81:77-79.
Aarabi B, Hesdorffer DC, Ahn ES, Aresco C, Scalea TM, Eisenberg HM. Outcome following decompressive craniectomy for malignant swelling due to severe head injury. J Neurosurg. 2006;104(4):469-479.
Kolias AG, Adams H, Timofeev IS, et al. Evaluation of outcomes among patients with traumatic intracranial hypertension treated with decompressive craniectomy vs standard medical care at 24 months: a secondary analysis of the RESCUEicp randomized clinical trial. JAMA Neurol. 2022;79(7):664-671.
Cnossen MC, Huijben JA, van der Jagt M, et al. Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: a survey in 66 neurotrauma centers participating in the CENTER-TBI study. Crit Care. 2017;21(1):233.
Malcolm JG, Rindler RS, Chu JK, et al. Early Cranioplasty is associated with greater neurological improvement: a systematic review and meta-analysis. Neurosurgery. 2018;82(3):278-288.
De Cola MC, Corallo F, Pria D, Lo Buono V, Calabrò RS. Timing for cranioplasty to improve neurological outcome: a systematic review. Brain Behav. 2018;8(11):e01106.
Morton RP, Abecassis IJ, Hanson JF, et al. Timing of cranioplasty: a 10.75-year single-center analysis of 754 patients. J Neurosurg. 2018;128(6):1648-1652.
Bender A, Heulin S, Röhrer S, et al. Early cranioplasty may improve outcome in neurological patients with decompressive craniectomy. Brain Inj. 2013;27(9):1073-1079.
Chibbaro S, Di Rocco F, Mirone G, et al. Decompressive craniectomy and early cranioplasty for the management of severe head injury: a prospective multicenter study on 147 patients. World Neurosurg. 2011;75(3-4):558-562.
De Bonis P, Frassanito P, Mangiola A, Nucci CG, Anile C, Pompucci A. Cranial repair: how complicated is filling a “hole”? J Neurotrauma. 2012;29(6):1071-1076.
Piedra MP, Nemecek AN, Ragel BT. Timing of cranioplasty after decompressive craniectomy for trauma. Surg Neurol Int. 2014;5:25.
Mee H, Anwar F, Timofeev I, et al. Cranioplasty: a multidisciplinary approach. Front Surg. 2022;9:864385.
Li A, Azad TD, Veeravagu A, et al. Cranioplasty complications and costs: a national population-level analysis using the MarketScan longitudinal database. World Neurosurg. 2017;102:209-220.
Liu L, Lu ST, Liu AH, et al. Comparison of complications in cranioplasty with various materials: a systematic review and meta-analysis. Br J Neurosurg. 2020;34(4):388-396.
Ashayeri K, M Jackson E, Huang J, Brem H, Gordon CR. Syndrome of the trephined: a systematic review. Neurosurgery. 2016;79(4):525-534.
Iaccarino C, Kolias A, Adelson PD, et al. Consensus statement from the international consensus meeting on post-traumatic cranioplasty. Acta Neurochir (Wien). 2021;163(2):423-440.
Maas AI, Menon DK, Steyerberg EW, et al. Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study. Neurosurgery. 2015;76(1):67-80.
Approved proposals. CENTER-TBI. Accessed February 15, 2024. https://www.center-tbi.eu/data/approved-proposals
Vandenbroucke JP, von Elm E, Altman DG, et al. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. Int J Surg. 2014;12(12):1500-1524.
Chang V, Hartzfeld P, Langlois M, Mahmood A, Seyfried D. Outcomes of cranial repair after craniectomy. J Neurosurg. 2010;112(5):1120-1124.
Song J, Liu M, Mo X, Du H, Huang H, Xu GZ. Beneficial impact of early cranioplasty in patients with decompressive craniectomy: evidence from transcranial Doppler ultrasonography. Acta Neurochir (Wien). 2014;156(1):193-198.
Wilson JT, Pettigrew LE, Teasdale GM. Structured interviews for the Glasgow Outcome Scale and the extended Glasgow Outcome Scale: guidelines for their use. J Neurotrauma. 1998;15(8):573-585.
von Steinbüchel N, Petersen C, Bullinger M. Assessment of health-related quality of life in persons after traumatic brain injury—development of the Qolibri, a specific measure. Acta Neurochir Suppl. 2005;93:43-49.
Steyerberg EW, Mushkudiani N, Perel P, et al. Predicting outcome after traumatic brain injury: development and international validation of prognostic scores based on admission characteristics. PLoS Med. 2008;5(8):e165.
Roozenbeek B, Lingsma HF, Lecky FE, et al. Prediction of outcome after moderate and severe traumatic brain injury: external validation of the International Mission on Prognosis and Analysis of Clinical Trials (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models. Crit Care Med. 2012;40(5):1609-1617.
Murray GD, Butcher I, McHugh GS, et al. Multivariable prognostic analysis in traumatic brain injury: results from the IMPACT study. J Neurotrauma. 2007;24(2):329-337.
Iaccarino C, Kolias AG, Roumy LG, Fountas K, Adeleye AO. Cranioplasty following decompressive craniectomy. Review. Front Neurol. 2020;10(1357):1357.
Malcolm JG, Rindler RS, Chu JK, Grossberg JA, Pradilla G, Ahmad FU. Complications following cranioplasty and relationship to timing: a systematic review and meta-analysis. J Clin Neurosci. 2016;33:39-51.
Won YD, Yoo DS, Kim KT, et al. Cranioplasty effect on the cerebral hemodynamics and cardiac function. Acta Neurochir Suppl (Wien). 2008;102:15-20.
Halani SH, Chu JK, Malcolm JG, et al. Effects of cranioplasty on cerebral blood flow following decompressive craniectomy: a systematic review of the literature. Neurosurgery. 2017;81(2):204-216.
Stiver SI, Wintermark M, Manley GT. Motor trephine syndrome: a mechanistic hypothesis. Acta Neurochir Suppl (Wien). 2008;102:273-277.
Czosnyka M, Copeman J, Czosnyka Z, McConnell R, Dickinson C, Pickard JD. Post-traumatic hydrocephalus: influence of craniectomy on the CSF circulation. J Neurol Neurosurg Psychiatry. 2000;68(2):246-248.
Aloraidi A, Alkhaibary A, Alharbi A, et al. Effect of cranioplasty timing on the functional neurological outcome and postoperative complications. Surg Neurol Int. 2021;12:264.
Worm PV, Finger G, Ludwig do Nascimento T, Rynkowski CB, Collares MVM. The impact of cranioplasty on the patients’ quality of life. J Craniomaxillofac Surg. 2019;47(5):715-719.
Posti JP, Yli-Olli M, Heiskanen L, et al. Cranioplasty after severe traumatic brain injury: effects of trauma and patient recovery on cranioplasty outcome. Front Neurol. 2018;9:223.
Meier U, Gräwe A, König A. The importance of major extracranial injuries by the decompressive craniectomy in severe head injuries. Acta Neurochir Suppl. 2005;95:55-57.
Brookhart MA, Rassen JA, Schneeweiss S. Instrumental variable methods in comparative safety and effectiveness research. Pharmacoepidemiol Drug Saf. 2010;19(6):537-554.
Cnossen MC, van Essen TA, Ceyisakar IE, et al. Adjusting for confounding by indication in observational studies: a case study in traumatic brain injury. Clin Epidemiol. 2018;10:841-852.
van Essen TA, Menon DK, Lingsma HF. Unmeasured confounding in observational studies of management of cerebellar intracranial hemorrhage. JAMA. 2020;323(7):665-666.
van Essen TA, Lingsma HF, Pisică D, et al. Surgery versus conservative treatment for traumatic acute subdural haematoma: a prospective, multicentre, observational, comparative effectiveness study. Lancet Neurol. 2022;21(7):620-631.
Rashidi A, Sandalcioglu IE, Luchtmann M. Aseptic bone-flap resorption after cranioplasty—incidence and risk factors. PLoS One. 2020;15(1):e0228009.
Oh JS, Lee KS, Shim JJ, Yoon SM, Doh JW, Bae HG. Which one is better to reduce the infection rate, early or late cranioplasty? J Korean Neurosurg Soc. 2016;59(5):492-497.
Maas AIR, Roozenbeek B, Manley GT. Clinical trials in traumatic brain injury: past experience and current developments. Neurotherapeutics. 2010;7(1):115-126.