Da Veiga, Marc-Antoine ; Université de Liège - ULiège > GIGA > GIGA Neurosciences - Nervous system disorders and therapy
Rogister, Bernard ; Université de Liège - ULiège > GIGA > GIGA Neurosciences - Nervous system disorders and therapy ; Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie
Piette, Caroline ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pédiatrie
D.N. Louis et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary Acta Neuropathol. (Berl.) 131 803 820 27157931 10.1007/s00401-016-1545-1
D.N. Louis et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary Neuro-Oncol. 23 1231 1251 1:CAS:528:DC%2BB3MXisFSht73J 34185076 8328013 10.1093/neuonc/noab106
Q.T. Ostrom et al. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2016—2020 Neuro-Oncol 25 iv1 iv99 37793125 10550277 10.1093/neuonc/noad149
H. Pinson et al. Epidemiology and survival of adult-type diffuse glioma in Belgium during the molecular era Neuro-Oncol. 26 191 202 37651614 10.1093/neuonc/noad158
R. Stupp et al. Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma N. Engl. J. Med. 352 987 996 1:CAS:528:DC%2BD2MXit1Wksbk%3D 15758009 10.1056/NEJMoa043330
A. Mackay et al. Integrated Molecular Meta-Analysis of 1000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma Cancer Cell 32 520 537.e5 1:CAS:528:DC%2BC2sXhsFOrtrjL 28966033 5637314 10.1016/j.ccell.2017.08.017
P. Sharma A. Aaroe J. Liang V.K. Puduvalli Tumor microenvironment in glioblastoma: Current and emerging concepts Neuro-Oncol. Adv. 5 vdad009 10.1093/noajnl/vdad009
R. McLendon et al. Comprehensive genomic characterization defines human glioblastoma genes and core pathways Nature 455 1061 1068 1:CAS:528:DC%2BD1cXht1yju77J 10.1038/nature07385
R.G.W. Verhaak et al. An integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR and NF1 Cancer Cell 17 98 1:CAS:528:DC%2BC3cXkvFKgsL4%3D 20129251 2818769 10.1016/j.ccr.2009.12.020
H.S. Phillips et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis Cancer Cell 9 157 173 1:CAS:528:DC%2BD28XivFWjtL4%3D 16530701 10.1016/j.ccr.2006.02.019
A.P. Patel et al. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma Science 344 1396 1401 1:CAS:528:DC%2BC2cXpslygsL4%3D 24925914 4123637 10.1126/science.1254257
V.M. Ravi et al. Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma Cancer Cell 40 639 655.e13 1:CAS:528:DC%2BB38XitVehur%2FP 35700707 10.1016/j.ccell.2022.05.009
L.M. Richards et al. Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity Nat. Cancer 2 157 173 1:CAS:528:DC%2BB38XjsFeisb4%3D 35122077 10.1038/s43018-020-00154-9
Q. Wang et al. Tumor evolution of glioma intrinsic gene expression subtype associates with immunological changes in the microenvironment Cancer Cell 32 42 56.e6 28697342 5599156 10.1016/j.ccell.2017.06.003
L. Wang et al. The Phenotypes of Proliferating Glioblastoma Cells Reside on a Single Axis of Variation Cancer Discov 9 1708 1719 1:CAS:528:DC%2BB3cXht1Ght7rK 31554641 7161589 10.1158/2159-8290.CD-19-0329
C. Neftel et al. An integrative model of cellular states, plasticity and genetics for glioblastoma Cell 178 835 849.e21 1:CAS:528:DC%2BC1MXhsVWlur7I 31327527 6703186 10.1016/j.cell.2019.06.024
N. Abdelfattah et al. Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target Nat. Commun. 13 1:CAS:528:DC%2BB38Xjt1Cmu7g%3D 35140215 8828877 10.1038/s41467-022-28372-y 767
C.P. Couturier et al. Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy Nat. Commun. 11 1:CAS:528:DC%2BB3cXhtlOjtrzK 32641768 7343844 10.1038/s41467-020-17186-5 3406
L. Garofano et al. Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities Nat. Cancer 2 141 156 1:CAS:528:DC%2BB38XjsFeisLc%3D 33681822 7935068 10.1038/s43018-020-00159-4
Y. Ren et al. Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas Nat. Commun. 14 1:CAS:528:DC%2BB3sXht1entLfL 10.1038/s41467-023-36707-6 1
A.C. Greenwald et al. Integrative spatial analysis reveals a multi-layered organization of glioblastoma Cell 10 2485 2501 10.1016/j.cell.2024.03.029
R. Chanoch-Myers A. Wider M.L. Suva I. Tirosh Elucidating the diversity of malignant mesenchymal states in glioblastoma by integrative analysis Genome Med 14 1:CAS:528:DC%2BB38XisV2gtLfP 36123598 9484143 10.1186/s13073-022-01109-8 106
Mossi Albiach, A. et al. Glioblastoma is spatially organized by neurodevelopmental programs and a glial-like wound healing response, bioRXiv. Preprint, https://doi.org/10.1101/2023.09.01.555882 (2023).
M.G. Filbin et al. Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq Science 360 331 335 1:CAS:528:DC%2BC1cXns12gtLg%3D 29674595 5949869 10.1126/science.aao4750
I. Liu et al. The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location Nat. Genet. 54 1881 1894 1:CAS:528:DC%2BB38XjtVCjtL7K 36471067 9729116 10.1038/s41588-022-01236-3
S. Jessa et al. K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas Nat. Genet. 54 1865 1880 1:CAS:528:DC%2BB38XjtVCjtb%2FF 36471070 9742294 10.1038/s41588-022-01205-w
I. Liu et al. GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant Cancer Cell 42 1528 1548.e17 1:CAS:528:DC%2BB2cXhvV2hur7L 10.1016/j.ccell.2024.08.006
E. Braun et al. Comprehensive cell atlas of the first-trimester developing human brain Science 382 eadf1226 1:CAS:528:DC%2BB3sXitFygtbfF 37824650 10.1126/science.adf1226
W. Xian et al. Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis Front. Med. 18 147 168 37955814 10.1007/s11684-023-1017-7
A. Bhaduri et al. Outer Radial Glia-Like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma Cell Stem Cell 26 48 63.e6 1:CAS:528:DC%2BB3cXosVOit7o%3D 31901251 7029801 10.1016/j.stem.2019.11.015
C.C.L. Chen et al. Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis Cell 183 1617 1633.e22 1:CAS:528:DC%2BB3cXisVyntr7M 33259802 7791404 10.1016/j.cell.2020.11.012
J.J.D. Moffet et al. Spatial architecture of high-grade glioma reveals tumor heterogeneity within distinct domains Neuro-Oncol. Adv. 5 vdad142 10.1093/noajnl/vdad142
M.L. Suvà I. Tirosh The Glioma Stem Cell Model in the Era of Single-Cell Genomics Cancer Cell 37 630 636 32396858 10.1016/j.ccell.2020.04.001
Ruiz-Moreno, C. et al. Harmonized single-cell landscape, intercellular crosstalk and tumor architecture of glioblastoma, 27, 2022, bioRxiv. https://doi.org/10.1101/2022.08.27.505439.
R. Chaligne et al. Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states Nat. Genet. 53 1469 1479 1:CAS:528:DC%2BB3MXitFGru7vP 34594037 8675181 10.1038/s41588-021-00927-7
K.C. Johnson et al. Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response Nat. Genet. 53 1456 1468 1:CAS:528:DC%2BB3MXitFGru7vI 34594038 8570135 10.1038/s41588-021-00926-8
J. DeSisto et al. Tumor and immune cell types interact to produce heterogeneous phenotypes of pediatric high-grade glioma Neuro-Oncol 26 538 552 10912009 10.1093/neuonc/noad207
A.B. Levine et al. Immuno-oncologic profiling of pediatric brain tumors reveals major clinical significance of the tumor immune microenvironment Nat. Commun. 15 1:CAS:528:DC%2BB2cXhsFOntL7E 38987542 11237052 10.1038/s41467-024-49595-1 5790
S. Darmanis et al. Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma Cell Rep 21 1399 1410 1:CAS:528:DC%2BC2sXhslGit7zP 29091775 5810554 10.1016/j.celrep.2017.10.030
M.J. Haley et al. Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival Sci. Adv. 10 20 10.1126/sciadv.adj3301
T. Hara et al. Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma Cancer Cell 39 779 792.e11 1:CAS:528:DC%2BB3MXhtlSrt7jN 34087162 8366750 10.1016/j.ccell.2021.05.002
E. Gangoso et al. Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion Cell 184 2454 2470.e26 1:CAS:528:DC%2BB3MXptVWhsLo%3D 33857425 8099351 10.1016/j.cell.2021.03.023
V. Venkataramani et al. Glutamatergic synaptic input to glioma cells drives brain tumour progression Nature 573 532 538 1:CAS:528:DC%2BC1MXhvVSgtbzL 31534219 10.1038/s41586-019-1564-x
H.S. Venkatesh et al. Electrical and synaptic integration of glioma into neural circuits Nature 573 539 545 1:CAS:528:DC%2BC1MXhvVSgtb3I 31534222 7038898 10.1038/s41586-019-1563-y
V. Venkataramani et al. Glioblastoma hijacks neuronal mechanisms for brain invasion Cell 185 2899 2917.e31 1:CAS:528:DC%2BB38XhvFyrtrfJ 35914528 10.1016/j.cell.2022.06.054
H.S. Venkatesh et al. Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion Cell 161 803 816 1:CAS:528:DC%2BC2MXntFKjsL8%3D 25913192 4447122 10.1016/j.cell.2015.04.012
H.S. Venkatesh et al. Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma Nature 549 533 537 28959975 5891832 10.1038/nature24014
K.R. Taylor et al. Glioma synapses recruit mechanisms of adaptive plasticity Nature 623 366 374 1:CAS:528:DC%2BB3sXit1Klu7bP 37914930 10632140 10.1038/s41586-023-06678-1
M. Osswald et al. Brain tumour cells interconnect to a functional and resistant network Nature 528 93 98 1:CAS:528:DC%2BC2MXhslOrtLfJ 26536111 10.1038/nature16071
S. Weil et al. Tumor microtubes convey resistance to surgical lesions and chemotherapy in gliomas Neuro-Oncol 19 1316 1326 1:CAS:528:DC%2BC1cXit1ajtbfF 28419303 5596180 10.1093/neuonc/nox070
R.B. Puchalski et al. An anatomic transcriptional atlas of human glioblastoma Science 360 660 663 1:CAS:528:DC%2BC1cXptV2murY%3D 29748285 6414061 10.1126/science.aaf2666
L. Wang et al. A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets Nat. Cancer 3 1534 1552 1:CAS:528:DC%2BB38XjtF2gs7bL 36539501 9767870 10.1038/s43018-022-00475-x
Y. Zheng F. Carrillo-Perez M. Pizurica D.H. Heiland O. Gevaert Spatial cellular architecture predicts prognosis in glioblastoma Nat. Commun. 14 10.1038/s41467-023-39933-0 1
F.S. Varn et al. Glioma progression is shaped by genetic evolution and microenvironment interactions Cell 185 2184 2199.e16 1:CAS:528:DC%2BB38XhsVWjt7fE 35649412 9189056 10.1016/j.cell.2022.04.038
S. Venneti et al. Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways Cancer Discov 13 2370 2393 1:CAS:528:DC%2BB3sXis1Gjtr3J 37584601 10618742 10.1158/2159-8290.CD-23-0131
E.R. Jackson et al. ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma Cancer Res 83 2421 2437 1:CAS:528:DC%2BB3sXhvVymt7bP 37145169 10345962 10.1158/0008-5472.CAN-23-0186
J.M. Przystal et al. Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas Neuro-Oncol 24 1438 1451 1:CAS:528:DC%2BB3sXlsVGrsbs%3D 35157764 9435508 10.1093/neuonc/noac041
E. Karimi et al. Single-cell spatial immune landscapes of primary and metastatic brain tumours Nature 614 555 563 1:CAS:528:DC%2BB3sXisVKhsLY%3D 36725935 9931580 10.1038/s41586-022-05680-3
R.R. Maas et al. The local microenvironment drives activation of neutrophils in human brain tumors Cell 186 4546 4566.e27 1:CAS:528:DC%2BB3sXitVSqtrnO 37769657 10.1016/j.cell.2023.08.043
Miller, T.E. et al. Programs, Origins, and Niches of Immunomodulatory Myeloid Cells in Gliomas. https://doi.org/10.1101/2023.10.24.563466 (2023).
