[en] Sleep, circadian rhythms, and mental health are reciprocally interlinked. Disruption to the quality, continuity, and timing of sleep can precipitate or exacerbate psychiatric symptoms in susceptible individuals, while treatments that target sleep-circadian disturbances can alleviate psychopathology. Conversely, psychiatric symptoms can reciprocally exacerbate poor sleep and disrupt clock-controlled processes. Despite progress in elucidating underlying mechanisms, a cohesive approach that integrates the dynamic interactions between psychiatric disorder with both sleep and circadian processes is lacking. This review synthesizes recent evidence for sleep-circadian dysfunction as a transdiagnostic contributor to a range of psychiatric disorders, with an emphasis on biological mechanisms. We highlight observations from adolescent and young adults, who are at greatest risk of developing mental disorders, and for whom early detection and intervention promise the greatest benefit. In particular, we aim to a) integrate sleep and circadian factors implicated in the pathophysiology and treatment of mood, anxiety, and psychosis spectrum disorders, with a transdiagnostic perspective; b) highlight the need to reframe existing knowledge and adopt an integrated approach which recognizes the interaction between sleep and circadian factors; and c) identify important gaps and opportunities for further research.
Disciplines :
Neurosciences & behavior
Author, co-author :
Meyer, Nicholas ; Insomnia and Behavioural Sleep Medicine Clinic, University College London Hospitals NHS Foundation Trust, London WC1N 3HR, United Kingdom ; Department of Psychosis Studies, Institute of Psychology, Psychiatry, and Neuroscience, King's College London, London SE5 8AF, United Kingdom
Lok, Renske ; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305
Schmidt, Christina ; Université de Liège - ULiège > Département de Psychologie > Neuropsychologie de l'adulte
Kyle, Simon D ; Sir Jules Thorn Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX1 3QU, United Kingdom
McClung, Colleen A ; Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219
Cajochen, Christian ; Centre for Chronobiology, Department for Adult Psychiatry, Psychiatric Hospital of the University of Basel, Basel CH-4002, Switzerland ; Research Cluster Molecular and Cognitive Neurosciences, Department of Biomedicine, University of Basel, Basel CH-4055, Switzerland
Scheer, Frank A J L ; Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115 ; Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115 ; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115
Jones, Matthew W ; School of Physiology, Pharmacology and Neuroscience, Faculty of Health and Life Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
Chellappa, Sarah L ; School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom
Language :
English
Title :
The sleep-circadian interface: A window into mental disorders.
Publication date :
27 February 2024
Journal title :
Proceedings of the National Academy of Sciences of the United States of America
R.L. is supported by U.S. Department of Defense (W81XWH-16-1-0223); C.S. in part by ERC-Stg-GA757763 and FNRS-PDRT.0220.20; S.D.K. by the National Institute of Health and Care Research (NIHR) Oxford Health Biomedical Research Centre, NIHR Efficacy and Mechanisms Evaluation Programme (Ref: 131789), NIHR Programme Grants for Applied Research (Ref: 203667) and the Wellcome Trust (226784/Z/22/Z and 227093/Z/23/Z); C.A.M. from NIH grants MH111601, MH106460, DA039865, DA046346, F.A.J.L.S. by NIH grants R01-HL140574 and R01-HL153969; M.W.J. from Wellcome grant 226709/Z/22/Z and MRC grant MR/X009726/1; S.L.C. was supported by the Alexander von Humboldt Stifung. Figures were created with permission from http://Biorender.com.ACKNOWLEDGMENTS. R.L. is supported by U.S. Department of Defense (W81XWH-16-1-0223); C.S. in part by ERC-Stg-GA757763 and FNRS-PDR-T.0220.20; S.D.K. by the National Institute of Health and Care Research (NIHR) Oxford Health Biomedical Research Centre, NIHR Efficacy and Mechanisms Evaluation Programme (Ref: 131789), NIHR Programme Grants for Applied Research (Ref: 203667) and the Wellcome Trust (226784/Z/22/Z and 227093/Z/23/Z); C.A.M. from NIH grants MH111601, MH106460, DA039865, DA046346, F.A.J.L.S. by NIH grants R01-HL140574 and R01-HL153969; M.W.J. from Wellcome grant 226709/Z/22/Z and MRC grant MR/X009726/1; S.L.C. was supported by the Alexander von Humboldt Stifung. Figures were created with permission from http://Biorender.com.
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