[en] [en] BACKGROUND: The Embolus Retriever with Interlinked Cages (ERIC) is one of the latest devices for thrombectomies. It has several architectural features that are supposed to enhance its ability to remove clots and prevent distal emboli. We aimed to compare ERIC with standard stent retrievers (SRs) using propensity score (PS) matching.
METHODS: The clinical and radiological data of all consecutive patients treated with ERIC or standard FDA-approved stent retrievers were collected from a prospective multicenter registry. We compared procedural outcomes (recanalization rates according to the modified Thrombolysis In Cerebral Infarction (mTICI) score and procedural complications) and clinical outcomes (modified Rankin Scale (mRS) and mortality at 3 months). Matching of the populations with PS was performed to account for differences in baseline characteristics.
RESULTS: A total of 1230 patients were included. In both the PS-matched cohort (195 ERIC patients, 630 SR patients) and the inverse probability of treatment weighting PS-adjusted cohort (206 ERIC patients, 1024 SR patients) there was no difference in terms of successful recanalization (modified TICI score ≥2b), good clinical outcome (mRS=0-2 or equal to pre-stroke mRS), or mortality at 3 months. Patients treated with first-line ERIC had a higher rate of complete recanalization (mTICI 3); however, they also required more passes and more frequent rescue therapy than the SR patient group.
CONCLUSION: In a large multicenter registry with PS matching, the ERIC device provided equivalent angiographic and clinical results to conventional SRs.
CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov Unique identifier: NCT03776877.
Disciplines :
Neurology
Author, co-author :
Ducroux, Célina; Interventional Neuroradiology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
Renaud, Nicolas; Neuroradiology, Centre Hospitalier Universitaire de Nantes, Nantes, Pays de la Loire, France
Bourcier, Romain; Neuroradiology, Centre Hospitalier Universitaire de Nantes, Nantes, Pays de la Loire, France
Marnat, Gaultier ; Interventional and Diagnostic Neuroradiology, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, Aquitaine, France
Sibon, Igor; Neurology, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, Aquitaine, France
Gory, Benjamin; Diagnostic and Interventional Neuroradiology, Centre Hospitalier Régional Universitaire de Nancy, Nancy, Lorraine, France
Richard, Sébastien; Neurology Stroke Unit, Centre Hospitalier Régional Universitaire de Nancy, Nancy, France
Dargazanli, Cyril; Neuroradiology, Centre Hospitalier Universitaire Gui de Chauliac, Montpellier, Occitanie, France
Arquizan, Caroline; Neurology, Centre Hospitalier Universitaire Gui de Chauliac, Montpellier, France
Eugene, Francois ; Neuroradiology, Centre Hospitalier Universitaire de Rennes, Rennes, France
Vannier, Stephane; Neurology, Centre Hospitalier Universitaire de Rennes, Rennes, France
Labreuche, Julien; Biostatistics, Centre Hospitalier Universitaire de Lille, Lille, France
Walker, Gregory; Department of Medicine - Division of Neurology, Ottawa Hospital, Ottawa, Ontario, Canada ; Department of Medicine - Division of Neurology, Royal Columbian Hospital, New Westminster, British Columbia, Canada
Blanc, Raphaël ; Interventional Neuroradiology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
Obadia, Mickael; Neurology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, Île-de-France, France
Consoli, Arturo; Neuroradiology, Foch Hospital, Suresnes, Île-de-France, France
Lapergue, Bertrand; Neurology, Foch Hospital, Suresnes, France
Fahed, Robert ; Interventional Neuroradiology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France robert.fahed@hotmail.fr ; Department of Medicine - Division of Neurology, Ottawa Hospital, Ottawa, Ontario, Canada
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