Influence of Implant Component Materials on Peri-Implant Soft Tissue Healing: A Comparative Histological and Immunohistochemical Study in Humans.

Liegeois, Lemmy; Borie, Manon; Lecloux, Geoffrey; Van hede, Dorien; Lambert, France

doi:10.1111/clr.14391

Article (Scientific journals)

Influence of Implant Component Materials on Peri-Implant Soft Tissue Healing: A Comparative Histological and Immunohistochemical Study in Humans.

Liegeois, Lemmy; Borie, Manon; Lecloux, Geoffrey et al.

2024 • In Clinical Oral Implants Research

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/326474

DOI
10.1111/clr.14391

PubMed
39676638

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Keywords :

abutment materials; dental implants; immunohistochemistry; inflammation; soft tissue; Oral Surgery

Abstract :

[en] [en] BACKGROUND: Recently, the importance of peri-implant soft tissue integration quality has been recognised as an essential factor in the long-term success of dental implant rehabilitation. AIM: The aim of this study was to explore the influence of three materials commonly used in implant dentistry, namely titanium (Ti), dental adhesive resin (Re) and polyetheretherketone (PEEK), on the peri-implant soft tissues. METHODS: In this clinical randomised comparative study, 37 bone-level implants were placed, and experimental transmucosal healing abutments made of different materials were randomly assigned to each implant. These abutments were removed together with the surrounding soft tissues after 8 weeks. Immunohistochemical analyses were performed to determine the presence and localisation of different immune cells. In addition, clinical and radiographic data were collected and peri-implant bone remodeling was assessed. RESULTS: Compared to the Ti and PEEK groups, Re abutments revealed a higher infiltration of macrophages in the connective tissue (p = 0.04) and neutrophils in the adjacent epithelium (p = 0.03). In the Re abutments, peri-implant bone remodeling was higher compared to the other groups (p = 0.01). CONCLUSION: The use of resin material as a transmucosal healing abutment should be carefully considered as it was associated with a higher presence of inflammatory cells at 8 weeks post-implantation as well as superior bone remodeling compared to PEEK and Ti.

Research Center/Unit :

d‐BRU - Dental Biomaterials Research Unit - ULiège

Disciplines :

Dentistry & oral medicine

Author, co-author :

Liegeois, Lemmy ; Centre Hospitalier Universitaire de Liège - CHU > > Service de parodontologie, chirurgie bucco-dentaire et chirurgie implantaire

Borie, Manon ; Université de Liège - ULiège > Dental biomaterials research unit (d-BRU)

Lecloux, Geoffrey ; Université de Liège - ULiège > Département des sciences dentaires > Chirurgie bucco-dentaire et parodontologie

Van hede, Dorien ^✱; Université de Liège - ULiège > Département des sciences dentaires > Biomatériaux dentaires

Lambert, France ^✱; Université de Liège - ULiège > Département des sciences dentaires > Chirurgie bucco-dentaire et parodontologie

^✱ These authors have contributed equally to this work.

Language :

English

Title :

Influence of Implant Component Materials on Peri-Implant Soft Tissue Healing: A Comparative Histological and Immunohistochemical Study in Humans.

Publication date :

16 December 2024

Journal title :

Clinical Oral Implants Research

ISSN :

0905-7161

eISSN :

1600-0501

Publisher :

John Wiley and Sons Inc, Denmark

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://onlinelibrary.wiley.com/doi/pdf/10.1111/clr.14391

Funders :

ITI - ITI Foundation

Funding text :

This work was supported by ITI Foundation, 1515\u20102020. Funding:This study was supported by the grant of the International Team for Implantology (ITI, grant number 1515\u20102020, Basel, Switzerland). The authors thank Dr. Bekisz, Dr. Bolette, Dr. Debaty and Dr. Thaillard for their contribution to patient inclusion and their clinical expertise. Dr. Somja is acknowledged for their expertise and contribution to anapathological analyses. Pr. Albert and Mrs. Seidel are acknowledged for their statistical analysis.

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