[en] Polychlorinated naphthalenes (PCNs) are toxic and can accumulate through the food chain. PCNs have been detected in different categories of foods. Intake of animal-derived foods is an important pathway for human exposure to PCNs. However, information on PCNs in meat from farmed animals is scarce. In this study, PCNs were assessed in beef sourced from local markets in Beijing and six provinces in China. The mean PCN concentrations in beef samples from the seven regions varied from 41.2 to 88.7 pg/g wet weight (ww). The homologue profiles of PCNs in the specimens were similar, with tri- and di-CNs being dominant. The mean concentration of PCNs in the flank (74.7 pg/g ww) was higher than that in the round (58.2 pg/g ww) or shank (53.6 pg/g ww), likely because the former contained a higher proportion of lipids than the latter. Significantly different PCN distributions in beef and dairy cow milk were identified using machine learning. The toxic equivalencies (TEQs) of PCNs in all beef samples ranged from 0.0003 to 0.022 pg TEQ/g ww. PCNs contributed to approximately 4.6% of the total TEQ values of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, polychlorinated biphenyls, and PCNs in the beef. Health risks related to the intake of PCNs through beef consumption by the average person living in China were minimal.
Disciplines :
Chemistry
Author, co-author :
Dong, Shujun ; Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing, 100081, China
Li, Jingguang; NHC Key Laboratory of Food Safety Risk Assessment, Food Safety Research Unit (2019RU014) of Chinese Academy of Medical Science, China National Center for Food Safety Risk Assessment, Beijing, 100021, China
Zhang, Lei; NHC Key Laboratory of Food Safety Risk Assessment, Food Safety Research Unit (2019RU014) of Chinese Academy of Medical Science, China National Center for Food Safety Risk Assessment, Beijing, 100021, China
Zhang, Su; Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing, 100081, China
Zou, Yun ; Organic Biological Analytical Chemistry Group, Department of Chemistry, University of Liège, Liège, 4000, Belgium
Zhao, Yunfeng; NHC Key Laboratory of Food Safety Risk Assessment, Food Safety Research Unit (2019RU014) of Chinese Academy of Medical Science, China National Center for Food Safety Risk Assessment, Beijing, 100021, China
Wu, Yongning; NHC Key Laboratory of Food Safety Risk Assessment, Food Safety Research Unit (2019RU014) of Chinese Academy of Medical Science, China National Center for Food Safety Risk Assessment, Beijing, 100021, China
Wang, Peilong; Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing, 100081, China. Electronic address: wangpeilong@caas.cn
Language :
English
Title :
Distributions of polychlorinated naphthalenes in beef from China and associated health risks.
This study was supported by the Central Public Interest Scientific Institution Basal Research Fund of the Chinese Academy of Agricultural Sciences (grant no. Y2022PT20 ) and by the Agricultural Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences (Feed Quality and Safety).
Bidleman, T., Helm, P., Braune, B., Gabrielsen, G., Polychlorinated naphthalenes in polar environments- A review. Sci. Total Environ. 408 (2010), 2919–2935, 10.1016/j.scitotenv.2009.09.013.
Chinese Nutrition Society. Chinese Dietary Guidelines 2022. 2022, People's Medical Publishing House (in Chinese).
Cui, L., Wang, S., Gao, L., Huang, H., Xia, D., Qiao, L., Liu, W., Concentrations and trophic magnification of polychlorinated naphthalenes (PCNs) in marine fish from the Bohai coastal area, China. Environ. Pollut. (Amsterdam, Neth.) 234 (2018), 876–884, 10.1016/j.envpol.2017.12.028.
Domingo, J.L., Polychlorinated naphthalenes in animal aquatic species and human exposure through the diet: a review. J. Chromatogr. A 2054 (2004), 327–334, 10.1016/j.chroma.2004.03.072.
Domingo, J.L., Falco, G., Llobet, J.M., Casas, C., Teixido, A., Muller, L., Polychlorinated naphthalenes in foods: estimated dietary intake by the population of Catalonia, Spain. Environ. Sci. Technol. 37 (2003), 2332–2335, 10.1021/es030009b.
Dong, S., Li, X., Wang, P., Su, X., Polychlorinated naphthalene concentrations and distribution in feed raw materials. Chemosphere 211 (2018), 912–917, 10.1016/j.chemosphere.2018.08.037.
Dong, S., Liu, G., Li, X., Factors that affect polychlorinated naphthalenes formation and distribution during the heating of sucralose. Food Chem. 276 (2019), 397–401, 10.1016/j.foodchem.2018.10.050.
Dong, S., Li, J., Zheng, B., Zhang, L., Zhang, S., Zou, Y., Wang, Y., Fan, M., Wang, R., Li, Y., Wu, Y., Su, X., Wang, P., Occurrence and source analysis of polychlorinated naphthalenes in raw cow milk. Food Chem., 381, 2022, 132247, 10.1016/j.foodchem.2022.132247.
Dong, S., Zhang, S., Zou, Y., Li, T., Wang, R., Wang, Y., Zhao, Y., Cheng, J., Wu, G., Wang, P., Pilot study on the effect of secondary copper smelters on polychlorinated naphthalene contamination in surrounding agricultural areas. Sci. Total Environ., 852, 2022, 158223, 10.1016/j.scitotenv.2022.158223.
EPA. Risk Assessment Guidance for Superfund Volume I Human Health Evaluation Manual (Part A). 1989, 205.
EPA. National Oil and Hazardous Substances Pollution Contingency Plan (NCP). 1994 accessed. (Accessed 23 August 2022)
Falandysz, J., Fernandes, A., Gregoraszczuk, E., Rose, M., The toxicological effects of halogenated naphthalenes: a review of aryl hydrocarbon receptor-mediated (dioxin-like) relative potency factors. J. Environ. Sci. Heal. C 32 (2014), 239–272, 10.1080/10590501.2014.938945.
Fernandes, A.R., Mortimer, D., Gem, M., Smith, F., Rose, M., Panton, S., Carr, M., Polychlorinated naphthalenes (PCNs): congener specific analysis, occurrence in food, and dietary exposure in the UK. Environ. Sci. Technol. 44 (2010), 3533–3538, 10.1021/es903502g.
Fernandes, A.R., Tlustos, C., Rose, M., Smith, F., Carr, M., Panton, S., Polychlorinated naphthalenes (PCNs) in Irish foods: occurrence and human dietary exposure. Chemosphere 85 (2011), 322–328, 10.1016/j.chemosphere.2011.06.093.
Fernandes, A.R., Rose, M., Falandysz, J., Polychlorinated naphthalenes (PCNs) in food and humans. Environ. Int. 104 (2017), 1–13, 10.1016/j.envint.2017.02.015.
Fernandes, A., Falandysz, J., Yuan, B., Widening knowledge horizons on legacy POPs: chlorinated paraffins and polychlorinated naphthalenes. Chemosphere, 289, 2022, 133131, 10.1016/j.chemosphere.2021.133131.
Fernandes, A.R., Kilanowicz, A., Stragierowicz, J., Klimczak, M., Falandysz, J., The toxicological profile of polychlorinated naphthalenes (PCNs). Sci. Total Environ., 837, 2022, 155764, 10.1016/j.scitotenv.2022.155764.
González, N., Domingo, J.L., Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in food and human dietary intake: an update of the scientific literature. Food Chem. Toxicol., 157, 2021, 112585, 10.1016/j.fct.2021.112585.
Hirako, M., Distribution of PCDDs, PCDFs and dioxin-like PCBs in the blood, testis and adipose tissue of suckling beef calves. Chemosphere 71 (2008), 219–226, 10.1016/j.chemosphere.2007.09.047.
Huwe, J.K., Smith, D.J., Laboratory and on-farm studies on the bioaccumulation and elimination of dioxins from a contaminated mineral supplement fed to dairy cows. J. Agric. Food Chem. 53 (2005), 2362–2370, 10.1021/jf0480997.
Jin, R., Fu, J., Zheng, M., Yang, L., Habib, A., Li, C., Liu, G., Polychlorinated naphthalene congener profiles in common vegetation on the Tibetan Plateau as biomonitors of their sources and transportation. Environ. Sci. Technol. 54 (2020), 2314–2322, 10.1021/acs.est.9b06668.
Jin, R., Zheng, M., Yang, L., Zhang, Q., Fu, J., Yang, R., Liu, Q., Shi, J., Liu, G., Jiang, G., Indoor exposure to products of incomplete combustion of household fuels in rural Tibetan Plateau. Environ. Sci. Technol. 56 (2022), 4711–4714, 10.1021/acs.est.1c05298.
Knutsen, H.K., Alexander, J., Barregard, L., Bignami, M., Bruschweiler, B., Ceccatelli, S., Cottrill, B., Dinovi, M., Edler, L., Grasl-Kraupp, B., Hogstrand, C., Nebbia, C.S., Oswald, I.P., Petersen, A., Rose, M., Roudot, A.C., Schwerdtle, T., Vleminckx, C., Vollmer, G., Wallace, H., Furst, P., Hakansson, H., Halldorsson, T., Lundebye, A.K., Pohjanvirta, R., Rylander, L., Smith, A., Van Loveren, H., Waalkens-Berendsen, I., Zeilmaker, M., Binaglia, M., Ruiz, J.A.G., Horvath, Z., Christoph, E., Ciccolallo, L., Bordajandi, L.R., Steinkeliner, H., Hoogenboom, L., Chain, E.P.C.F., Risk for animal and human health related to the presence of dioxins and dioxin-like PCBs in feed and food. EFSA J., 16, 2018, 5333, 10.2903/j.efsa.2018.5333.
Li, L., Sun, S., Dong, S., Jiang, X., Liu, G., Zheng, M., Polychlorinated naphthalene concentrations and profiles in cheese and butter, and comparisons with polychlorinated dibenzo-p-dioxin, polychlorinated dibenzofuran and polychlorinated biphenyl concentrations. Int. J. Environ. Anal. Chem. 95 (2015), 203–216, 10.1080/03067319.2014.1002491.
Li, C., Zhang, L., Li, J., Min, Y., Yang, L., Zheng, M., Wu, Y., Yang, Y., Qin, L., Liu, G., Polychlorinated naphthalenes in human milk: health risk assessment to nursing infants and source analysis. Environ. Int., 136, 2020, 105436, 10.1016/j.envint.2019.105436.
Li, C., Zhang, L., Yang, Q., Wu, Y., Zheng, M., Yang, L., Lyu, B., Liu, X., Jin, R., Sun, Y., Chen, C., Yang, Y., Qin, L., Lin, B., Li, D., Li, J., Liu, G., Comprehensive evaluation of dietary exposure and health risk of polychlorinated naphthalenes. Environ. Sci. Technol. 56 (2022), 5520–5529, 10.1021/acs.est.1c08614.
Li, X., Gu, W., Zhang, B., Xin, X., Kang, Q., Yang, M., Chen, B., Li, Y., Insights into toxicity of polychlorinated naphthalenes to multiple human endocrine receptors: mechanism and health risk analysis. Environ. Int., 165, 2022, 107291, 10.1016/j.envint.2022.107291.
Liu, G., Cai, Z., Zheng, M., Sources of unintentionally produced polychlorinated naphthalenes. Chemosphere 94 (2014), 1–12, 10.1016/j.chemosphere.2013.09.021.
Liu, G., Lv, P., Jiang, X., Nie, Z., Zheng, M., Identifying iron foundries as a new source of unintentional polychlorinated naphthalenes and characterizing their emission profiles. Environ. Sci. Technol. 48 (2014), 13165–13172 10.1021/es503161v.
Martí-Cid, R., Llobet, J.M., Castell, V., Domingo, J.L., Human exposure to polychlorinated naphthalenes and polychlorinated diphenyl ethers from foods in Catalonia, Spain: temporal trend. Environ. Sci. Technol. 42 (2008), 4195–4201, 10.1021/es800064p.
Park, H., Kang, J.H., Baek, S.Y., Chang, Y.S., Relative importance of polychlorinated naphthalenes compared to dioxins, and polychlorinated biphenyls in human serum from Korea: contribution to TEQs and potential sources. Environ. Pollut. (Amsterdam, Neth.) 158 (2010), 1420–1427, 10.1016/j.envpol.2009.12.039.
UNEP. Proposal to List Chlorinated Naphthalenes in Annexes A, B And/or C to the Stockholm Convention on Persistent Organic Pollutants. 2011 UNEP/POPS/POPRC.7/2 http://chm.pops.int/TheConvention/POPsReviewCommittee/Recommendations/tabid/243/Default.aspx.
United Nations Environment Program (UNEP). Report of the Conference of the Parties to the Stockholm Convention on Persistent Organic Pollutants on the Work of its Seventh Meeting., 2015 UNEP/POPS/COP/.7/36 http://chm.pops.int/TheConvention/ConferenceoftheParties/ReportsandDecisions/tabid/208/Default.aspx.
Van den Berg, M., Birnbaum, L.S., Denison, M., De Vito, M., Farland, W., Feeley, M., Fiedler, H., Hakansson, H., Hanberg, A., Haws, L., Rose, M., Safe, S., Schrenk, D., Tohyama, C., Tritscher, A., Tuomisto, J., Tysklind, M., Walker, N., Peterson, R.E., The 2005 World Health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol. Sci. 93 (2006), 223–241, 10.1093/toxsci/kfl055.
Weber, R., Iino, F., Imagawa, T., Takeuchi, M., Sakurai, T., Sadakata, M., Formation of PCDF, PCDD, PCB, and PCN in de novo synthesis from PAH: mechanistic aspects and correlation to fluidized bed incinerators. Chemosphere 44 (2001), 1429–1438, 10.1016/S0045-6535(00)00508-7.
Yang, L., Zheng, M., Zhu, Q., Yang, Y., Li, C., Liu, G., Inventory of polychlorinated naphthalene emissions from waste incineration and metallurgical sources in China. Environ. Sci. Technol. 54 (2020), 842–850 https://dx.dio.org//10.1021/ace.est.9b05539.
Yang, Y., Yang, L., Wang, M., Yang, Q., Liu, X., Shen, J., Liu, G., Zheng, M., Concentrations and profiles of persistent organic pollutants unintentionally produced by secondary nonferrous metal smelters: updated emission factors and diagnostic ratios for identifying sources. Chemosphere, 255, 2020, 126958, 10.1016/j.chemosphere.2020.126958.
Zacs, D., Perkons, I., Pasecnaja, E., Bartkevics, V., Polychlorinated naphthalenes (PCNs) in food products in Latvia: congener-specific analysis, occurrence, and dietary exposure of the general population. Chemosphere, 264, 2021, 128460, 10.1016/j.chemosphere.2020.128460.
Zeng, Y., Huang, C., Luo, X., Liu, Y., Ren, Z., Mai, B., Polychlorinated biphenyls and chlorinated paraffins in home-prodcuted eggs from an e-waste polluted area in South China: occurrence and human dietary exposure. Environ. Int. 116 (2018), 52–59, 10.1016/j.envint.2018.04.006.
