Article (Scientific journals)
Fabrication and characterization of magnesium-based nanocomposites reinforced with Baghdadite and carbon nanotubes for orthopaedical applications
Ansari, Mojtaba; Mahdavikia, Shiva; Eslami, Hossein et al.
2024In Journal of Magnesium and Alloys
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Keywords :
Baghdadite; Biodegradable material; Carbon nanotube; Magnesium-based composite; Spark plasma sintering; Bone regeneration; Bone repair; Clinical application; CNTs composites; Fabrication and characterizations; Magnesium based composite; Spark-plasma-sintering; Synthesised; Mechanics of Materials; Metals and Alloys
Abstract :
[en] This study explores the potential of Mg/Carbon Nanotubes/Baghdadite composites as biomaterials for bone regeneration and repair while addressing the obstacles to their clinical application. BAG powder was synthesized using the sol-gel method to ensure a fine distribution within the Mg/CNTs matrix. Mg/1.5 wt.% CNT composites were reinforced with BAG at weight fractions of 0.5, 1.0, and 1.5 wt.% using spark plasma sintering at 450 °C and 50 MPa after homogenization via ball milling. The cellular bioactivity of these nanocomposites was evaluated using human osteoblast-like cells and adipose-derived mesenchymal stromal cells. The proliferation and attachment of MG-63 cells were assessed and visualized using the methylthiazol tetrazolium (MTT) assay and SEM, while AD-MSC differentiation was measured using alkaline phosphatase activity assays. Histograms were also generated to visualize the diameter distributions of particles in SEM images using image processing techniques. The Mg/CNTs/0.5 wt.% BAG composite demonstrated optimal mechanical properties, with compressive strength, yield strength, and fracture strain of 259.75 MPa, 180.25 MPa, and 31.65 %, respectively. Machine learning models, including CNN, LSTM, and GRU, were employed to predict stress-strain relationships across varying BAG amounts, aiming to accurately model these curves without requiring extensive physical experiments. As shown by contact angle measurements, enhanced hydrophilicity promoted better cell adhesion and proliferation. Furthermore, corrosion resistance improved with a higher BAG content. This study concludes that Mg/CNTs composites reinforced with BAG concentrations below 1.0 wt.% offer promising biodegradable implant materials for orthopedic applications, featuring adequate load-bearing capacity and improved corrosion resistance.
Disciplines :
Materials science & engineering
Author, co-author :
Ansari, Mojtaba;  Department of Biomedical Engineering, Meybod University, Meybod, Iran
Mahdavikia, Shiva;  Department of Biomedical Engineering, Meybod University, Meybod, Iran
Eslami, Hossein ;  Department of Biomedical Engineering, Meybod University, Meybod, Iran
Saghalaini, Mozhdeh ;  Department of Biomedical Engineering, Amirkabir University of Technology, Iran
Taghipour, Hamid  ;  Université de Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM)
Zare, Fatemeh ;  Department of Electrical and Computer Engineering, Texas A&M University, College Station, United States
Shirani, Shahin;  Department of Biomedical Engineering, Amirkabir University of Technology, Iran
Alizadeh Roknabadi, Mohammad Hossein;  Department of Aerospace Engineering, Amirkabir University of Technology, Iran
Language :
English
Title :
Fabrication and characterization of magnesium-based nanocomposites reinforced with Baghdadite and carbon nanotubes for orthopaedical applications
Publication date :
2024
Journal title :
Journal of Magnesium and Alloys
eISSN :
2213-9567
Publisher :
KeAi Communications Co.
Peer reviewed :
Peer Reviewed verified by ORBi
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since 04 January 2025

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