Public Health, Environmental and Occupational Health; Infectious Diseases
Abstract :
[en] Aspergillosis causes significant health risks to both birds and mammals. The outcome of these infections is often poor due to delayed diagnosis and treatment failure. We investigated 152 cases of aspergillosis from birds and mammals in Belgium. Most samples originated from the taxonomic orders Artiodactyla (40.1 %) and Columbiformes (19.7 %). Five isolates (3.3 %) showed phenotypical resistance against at least one medical azole. Three of these isolates were pan-azole resistant bearing the TR34/L98H mutation. The predominance of this resistance mutation supports an environmental route for exposure and resistance selection, highlighting the importance of the One Health concept.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Debergh, Hanne ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) ; Scientific Department Mycology and Aerobiology, Sciensano, 1050 Brussels, Belgium
Botteldoorn, Nadine; Animal Health Care Flanders, Lier, Belgium
Martel, An; University of Ghent, Department of Pathobiology, Pharmacology and Zoological Medicine, 9820 Merelbeke, Belgium
Pasmans, Frank; University of Ghent, Department of Pathobiology, Pharmacology and Zoological Medicine, 9820 Merelbeke, Belgium
Saegerman, Claude ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Epidémiologie et analyse des risques appliqués aux sciences vétérinaires
Packeu, Ann; Scientific Department Mycology and Aerobiology, Sciensano, 1050 Brussels, Belgium ; BCCM/IHEM, Mycology and Aerobiology, Sciensano, 1050 Brussels, Belgium
Language :
English
Title :
Pan-azole resistance in clinical Aspergillus fumigatus isolates carrying TR34/L98H from birds and mammals in Belgium.
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