Article (Scientific journals)
openBF: an open-source finite volume 1D blood flow solver.
Benemerito, I; Melis, A; Wehenkel, Antoine et al.
2024In Physiological Measurement, 45 (12), p. 125002
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Keywords :
1D modelling; cardiovascular system; open source; validation; Humans; Hemodynamics; Models, Cardiovascular; Computer Simulation; Biomechanical Phenomena; Software; 1-D models; Blood flow; Computational libraries; Computational simulation; Finite-volume; Flow solver; Institute of Physics; Open-source; Physiological data; Biophysics; Physiology; Biomedical Engineering; Physiology (medical)
Abstract :
[en] Computational simulations are widely adopted in cardiovascular biomechanics because of their capability of producing physiological data otherwise impossible to measure with non-invasive modalities.Objective.This study presents openBF, a computational library for simulating the blood dynamics in the cardiovascular system.Approach.openBF adopts a one-dimensional viscoelastic representation of the arterial system, and is coupled with zero-dimensional windkessel models at the outlets. Equations are solved by means of the finite-volume method and the code is written in Julia. We assess its predictions by performing a multiscale validation study on several domains available from the literature.Main results.At all scales, which range from individual arteries to a population of virtual subjects, openBF's solution show excellent agreement with the solutions from existing software. For reported simulations, openBF requires low computational times.Significance.openBF is easy to install, use, and deploy on multiple platforms and architectures, and gives accurate prediction of blood dynamics in short time-frames. It is actively maintained and available open-source on GitHub, which favours contributions from the biomechanical community.
Disciplines :
Computer science
Electrical & electronics engineering
Author, co-author :
Benemerito, I ;  INSIGNEO Institute for in-silico medicine, University of Sheffield, Sheffield, United Kingdom ; Department of Mechanical Engineering, University of Sheffield, Sheffield, United Kingdom
Melis, A ;  VivaCity, London, United Kingdom
Wehenkel, Antoine  ;  Université de Liège - ULiège > Département d'électricité, électronique et informatique (Institut Montefiore) > Big Data
Marzo, A ;  INSIGNEO Institute for in-silico medicine, University of Sheffield, Sheffield, United Kingdom ; Department of Mechanical Engineering, University of Sheffield, Sheffield, United Kingdom
Language :
English
Title :
openBF: an open-source finite volume 1D blood flow solver.
Publication date :
2024
Journal title :
Physiological Measurement
ISSN :
0967-3334
Publisher :
Institute of Physics, England
Volume :
45
Issue :
12
Pages :
125002
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
UK EPSRC (CompBioMedX Project, Project ID: EP/X019446/1)
Funders :
EPSRC - Engineering and Physical Sciences Research Council
Funding text :
This study was funded by the UK EPSRC (CompBioMedX Project, Project ID: EP/X019446/1).
Available on ORBi :
since 16 December 2024

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