Article (Scientific journals)
Pseudo-epitheliomatous Hyperplasia and Skin Infections
Delahaye, Thibaut; Orduz-Robledo, Marianna; Beltran, A. Motta et al.
2024In Open Dermatology Journal, 18
Peer reviewed
 

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Keywords :
Bacteria; Cutaneous infection; Epidermal hyperplasia; Fungus; Parasite; Pseudo-epitheliomatous hyperplasia; Skin infection; Verruciform; Virus; Wart-like; Dermatology
Abstract :
[en] Introduction: The histological pattern of pseudo-epitheliomatous hyperplasia (PEH) may be encountered in a large series of verruciform/crateriform skin lesions (VC) with or without central ulceration/crusting. Beside neoplastic and inflammatory processes, this clinico-histological pattern may be associated with an extensive range of infectious agents. Materials and Methods: A literature search was performed to identify viral, bacterial, fungal, and parasitic mucocutaneous infections potentially presenting with a clinical/histological VC-PEH pattern. Results: A VC-PEH pattern was reported in parasitic (n=5), viral (n=6), bacterial (n=10), and fungal (n=12) mucocutaneous infections. The infection-linked VC-PEH pattern was typically linked to longstanding mucocutaneous processes. The human papillomavirus (HPV) family, Epstein-Barr virus, poxvirus, and polyomavirus-linked VC-PEH patterns seem to act as direct triggers of keratinocytic hyperproliferation whereas the VC-PEH patterns observed during other viral, parasitic, bacterial and fungal infections probably represent a reactive pattern of the epidermis to chronic mucocutaneous infections. The VC-PEH pattern was also more frequently reported in immunocompromised compared to immunocompetent patients. The risk of the development of a cutaneous squamous cell carcinoma in chronic VC-PEH should not be overlooked. Conclusion: In the event of longstanding, slowly progressing, isolated, or more profuse VC-PEH skin lesions, a thorough search for infectious agents should be considered, particularly in the immunocompromised patient.
Disciplines :
Dermatology
Author, co-author :
Delahaye, Thibaut  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de dermatologie
Orduz-Robledo, Marianna;  Departments of Dermatology, Universidad El Bosque, Bogota, Colombia
Beltran, A. Motta;  Departments of Dermatology, Universidad El Bosque, Bogota, Colombia
Robledo, Mary-Ann;  Medellin, Colombia
Sigha, Berline Odette;  University of Bamenda, Faculty of Health Sciences, Hôpital Laquintinie de Douala, Cameroon
Collins, Patrick ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Mokni, Mourad;  Department of Dermatology, Tunis University, Tunisia
Del Giudice, Pascal;  Department of Infectiology and Dermatology, Fréjus, Saint Raphaël, France
TASSOUDJI, Nazli ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de dermatologie
Nikkels, Arjen  ;  Université de Liège - ULiège > Département des sciences cliniques > Dermatologie
Language :
English
Title :
Pseudo-epitheliomatous Hyperplasia and Skin Infections
Publication date :
2024
Journal title :
Open Dermatology Journal
eISSN :
1874-3722
Publisher :
Bentham Science Publishers
Volume :
18
Peer reviewed :
Peer reviewed
Available on ORBi :
since 10 December 2024

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