[en] Vaccine-associated adverse events (VAAEs), including feline injection-site sarcomas (FISSs), occur only rarely but can be severe. Understanding potential VAAEs is an important part of informed owner consent for vaccination. In this review, the European Advisory Board on Cat Diseases (ABCD), a scientifically independent board of feline medicine experts, presents the current knowledge on VAAEs in cats, summarizing the literature and filling the gaps where scientific studies are missing with expert opinion to assist veterinarians in adopting the best vaccination practice. VAAEs are caused by an aberrant innate or adaptive immune reaction, excessive local reactions at the inoculation site, an error in administration, or failure in the manufacturing process. FISS, the most severe VAAE, can develop after vaccinations or injection of other substances. Although the most widely accepted hypothesis is that chronic inflammation triggers malignant transformation, the pathogenesis of FISS is not yet fully understood. No injectable vaccine is risk-free, and therefore, vaccination should be performed as often as necessary, but as infrequently as possible. Vaccines should be brought to room temperature prior to administration and injected at sites in which FISS surgery would likely be curative; the interscapular region should be avoided. Post-vaccinal monitoring is essential.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Hartmann, Katrin ; Small Animal Clinic, Centre for Clinical Veterinary Medicine, LMU Munich, 80539 Munich, Germany
Egberink, Herman ; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, University of Utrecht, 3584 CL Utrecht, The Netherlands
Möstl, Karin; Institute of Virology, Department for Pathobiology, University of Veterinary Medicine, 1210 Vienna, Austria
Addie, Diane D ; Maison Zabal, 64470 Etchebar, France
Belák, Sándor ; Department of Biomedical Sciences and Veterinary Public Health (BVF), Swedish University of Agricultural Sciences (SLU), P.O. Box 7036, 750 07 Uppsala, Sweden
Boucraut-Baralon, Corine; Scanelis Veterinary Test Laboratory, 31770 Colomiers, France
Frymus, Tadeusz ; Department of Small Animal Diseases with Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, 02-787 Warsaw, Poland
Hofmann-Lehmann, Regina ; Clinical Laboratory, Department of Clinical Diagnostics and Services, Vetsuisse Faculty, University of Zuich, 8057 Zurich, Switzerland
Marsilio, Fulvio ; Faculty of Veterinary Medicine, Università degli Studi di Teramo, 64100 Teramo, Italy
Pennisi, Maria Grazia ; Dipartimento di Scienze Veterinarie, Università di Messina, 98168 Messina, Italy
Tasker, Séverine ; Bristol Veterinary School, University of Bristol, Bristol BS40 5DU, UK ; Linnaeus Veterinary Ltd., Shirley, Solihull B90 4BN, UK
Thiry, Etienne ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI)
Truyen, Uwe; Institute of Animal Hygiene and Veterinary Public Health, University of Leipzig, 04103 Leipzig, Germany
Hosie, Margaret J ; MRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, UK
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