Decoding meditation mechanisms underlying brain preservation and psycho-affective health in older expert meditators and older meditation-naive participants.
[en] Meditation is a mental training approach that can improve mental health and well-being in aging. Yet the underlying mechanisms remain unknown. The Medit-Ageing model stipulates that three mechanisms - attentional, constructive, and deconstructive - upregulate positive psycho-affective factors and downregulate negative ones. To test this hypothesis, we measured brain structural MRI and perfusion, negative and positive psycho-affective composite scores, and meditation mechanisms in 27 older expert meditators and 135 meditation-naive older controls. We identified brain and psycho-affective differences and performed mediation analyses to assess whether and which meditation mechanisms mediate their links.Meditators showed significantly higher volume in fronto-parietal areas and perfusion in temporo-occipito-parietal areas. They also had higher positive and lower negative psycho-affective scores. Attentional and constructive mechanisms both mediated the links between brain differences and the positive psycho-affective score whereas the deconstructive mechanism mediated the links between brain differences and the negative psycho-affective score.Our results corroborate the Medit-Ageing model, indicating that, in aging, meditation leads to brain changes that decrease negative psycho-affective factors and increase positive ones through relatively specific mechanisms. Shedding light on the neurobiological and psycho-affective mechanisms of meditation in aging, these findings provide insights to refine future interventions.
Research Center/Unit :
GIGA CRC In vivo Imaging - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Haudry, Sacha; U1237, PhIND, Neuropresage Team, Normandy University, UNICAEN, INSERM, GIP Cyceron, Boulevard Henri Becquerel, Caen, 14000, France
Turpin, Anne-Laure; U1237, PhIND, Neuropresage Team, Normandy University, UNICAEN, INSERM, GIP Cyceron, Boulevard Henri Becquerel, Caen, 14000, France
Landeau, Brigitte; U1237, PhIND, Neuropresage Team, Normandy University, UNICAEN, INSERM, GIP Cyceron, Boulevard Henri Becquerel, Caen, 14000, France
Mézenge, Florence; U1237, PhIND, Neuropresage Team, Normandy University, UNICAEN, INSERM, GIP Cyceron, Boulevard Henri Becquerel, Caen, 14000, France
Delarue, Marion; U1237, PhIND, Neuropresage Team, Normandy University, UNICAEN, INSERM, GIP Cyceron, Boulevard Henri Becquerel, Caen, 14000, France
Hébert, Oriane; U1237, PhIND, Neuropresage Team, Normandy University, UNICAEN, INSERM, GIP Cyceron, Boulevard Henri Becquerel, Caen, 14000, France
Marchant, Natalie L; Division of Psychiatry, Faculty of Brain Sciences, University College London, London, UK
Klimecki, Olga; Developmental Psychology, Friedrich-Schiller-Universität Jena, Jena, Germany ; Biological Psychology, Faculty of Psychology, Technische Universität Dresden, Dresden, Germany
Collette, Fabienne ; Université de Liège - ULiège > Département de Psychologie ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory ; Université de Liège - ULiège > Psychologie et Neuroscience Cognitives (PsyNCog) > Cognition et Langage
Gonneaud, Julie; U1237, PhIND, Neuropresage Team, Normandy University, UNICAEN, INSERM, GIP Cyceron, Boulevard Henri Becquerel, Caen, 14000, France
de La Sayette, Vincent; Service de Neurologie, CHU de Caen, Caen, France
Vivien, Denis; PhIND "Physiopathology and Imaging of Neurological Disorders", Normandy University, UNICAEN, INSERM, U1237, Institut Blood & Brain @ Caen, Cyceron, Caen, 14000, France ; Département de Recherche Clinique, CHU Caen-Normandie, Caen, France
Lutz, Antoine; Lyon Neuroscience Research Center, INSERM U1028, CNRS UMR5292, Lyon 1 University, Lyon, France
Chételat, Gaël; U1237, PhIND, Neuropresage Team, Normandy University, UNICAEN, INSERM, GIP Cyceron, Boulevard Henri Becquerel, Caen, 14000, France. chetelat@cyceron.fr
Decoding meditation mechanisms underlying brain preservation and psycho-affective health in older expert meditators and older meditation-naive participants.
H2020 - 667696 - MEDIT-AGEING - Investigating the impact of meditation training on mental health and wellbeing in the ageing population
Name of the research project :
RIN Recherche 2020 pour le Label d’Excellence Medit-Ageing de la Région Normandie
Funders :
EU - European Union Alzheimer's Society SEFRI - Secrétariat d'État à la Formation, à la Recherche et à l'Innovation F.R.S.-FNRS - Fonds de la Recherche Scientifique Fondation Alzheimer Fondation d’Entreprise MMA des Entrepreneurs du Futur INSERM - Institut National de la Santé et de la Recherche Médicale ANR - Agence Nationale de la Recherche Région Normandie Association France-Alzheimer et Maladies Apparentées Fondation Vaincre Alzheimer European Union Fondation de France
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