Race-specific FRAX models are evidence-based and support equitable care: a response to the ASBMR Task Force report on Clinical Algorithms for Fracture Risk.
Kanis, John A; Harvey, Nicholas C; Lorentzon, Mattiaset al.
2024 • In Osteoporosis International, 35 (9), p. 1487 - 1496
FRAX adjustment; Fracture probability; Race and ethnicity; Racism; Humans; Risk Assessment/methods; Osteoporosis/ethnology; United States/epidemiology; Female; Osteoporotic Fractures/prevention & control; Osteoporotic Fractures/ethnology; Algorithms; Bone Density/physiology; Evidence-Based Medicine; Bone Density; Osteoporosis; Osteoporotic Fractures; Risk Assessment; United States; Endocrinology, Diabetes and Metabolism
Abstract :
[en] Task Force on 'Clinical Algorithms for Fracture Risk' commissioned by the American Society for Bone and Mineral Research (ASBMR) Professional Practice Committee has recommended that FRAX® models in the US do not include adjustment for race and ethnicity. This position paper finds that an agnostic model would unfairly discriminate against the Black, Asian and Hispanic communities and recommends the retention of ethnic and race-specific FRAX models for the US, preferably with updated data on fracture and death hazards. In contrast, the use of intervention thresholds based on a fixed bone mineral density unfairly discriminates against the Black, Asian and Hispanic communities in the US. This position of the Working Group on Epidemiology and Quality of Life of the International Osteoporosis Foundation (IOF) is endorsed both by the IOF and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO).
Disciplines :
Public health, health care sciences & services
Author, co-author :
Kanis, John A ; Mary McKillop Institute for Health Research, Catholic University, AustralianMelbourne, Australia. w.j.pontefract@shef.ac.uk ; Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK. w.j.pontefract@shef.ac.uk
Harvey, Nicholas C; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK ; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK
Lorentzon, Mattias; Mary McKillop Institute for Health Research, Catholic University, AustralianMelbourne, Australia ; Sahlgrenska Osteoporosis Centre, Institute of Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Liu, Enwu; Mary McKillop Institute for Health Research, Catholic University, AustralianMelbourne, Australia
Schini, Marian; Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK
Abrahamsen, Bo; Odense Patient Data Explorative Network, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
Adachi, Jonathan D; Department of Medicine, McMaster University, Hamilton, Canada
Alokail, Majed; Biochemistry Department, College of Science, Riyadh, Kingdom of Saudi Arabia
Borgstrom, Fredrik; Quantify Research, Stockholm, Sweden
Bruyère, Olivier ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Carey, John J ; School of Medicine, University of Galway, Galway, Ireland
Clark, Patricia; Clinical Epidemiology Research Unit, Hospital Infantil de Mexico "Federico Gomez", Mexico City, Mexico ; Faculty of Medicine of National Autonomous University of Mexico (Universidad, Nacional Autónoma de México), Mexico City, Mexico
Cooper, Cyrus ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé ; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK ; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK ; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK
Curtis, Elizabeth M ; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK
Dennison, Elaine M; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK ; Victoria University of Wellington, Wellington, New Zealand
Díaz-Curiel, Manuel; Metabolic Bone Diseases Unit, Department of Internal Medicine, Hospital Universitario Fundación Jiménez Díaz, Universidad Autónoma Madrid, Madrid, Spain
Dimai, Hans P; Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Styria, Austria
Grigorie, Daniel; Carol Davila University of Medicine, Bucharest, Romania ; Department of Endocrinology & Bone Metabolism, National Institute of Endocrinology, Bucharest, Romania
Hiligsmann, Mickaël ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé ; Department of Health Services Research, CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands
Khashayar, Patricia; International Institute for Biosensing, University of Minnesota, Minneapolis, USA
Lems, Willem; Department of Rheumatology, Amsterdam UMC, Location VUmc, Amsterdam, The Netherlands
Lewiecki, E Michael; New Mexico Clinical Research & Osteoporosis Center, Albuquerque, NM, USA
Lorenc, Roman S; Multidisciplinary Osteoporosis Forum, Warsaw, Poland, Poland
Papaioannou, Alexandra; McMaster University, Hamilton, ON, Canada
Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique ; Protein Research Chair, Biochemistry Dept, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia
Rizzoli, René ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé ; Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
Shiroma, Eric; Laboratory of Epidemiology and Population Sciences, National Institute On Aging, Baltimore, MD, USA
Silverman, Stuart L; Department of Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Simonsick, Eleanor; Translational Gerontology Branch, National Institute On Aging Intramural Research Program, Baltimore, MD, USA
Sosa-Henríquez, Manuel; University of Las Palmas de Gran Canaria, Grand Canaries, Spain
Szulc, Pawel; INSERM UMR 1033, University of Lyon, Hospital Edouard Herriot, Lyon, France
Ward, Kate A ; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK ; MRC Unit The Gambia, London School of Hygiene and Tropical Medicine, Banjul, The Gambia
Yoshimura, Noriko; Department of Preventive Medicine for Locomotive Organ Disorders, The University of Tokyo Hospital, Tokyo, Japan
Johansson, Helena; Mary McKillop Institute for Health Research, Catholic University, AustralianMelbourne, Australia ; Sahlgrenska Osteoporosis Centre, Institute of Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Vandenput, Liesbeth ; Mary McKillop Institute for Health Research, Catholic University, AustralianMelbourne, Australia
McCloskey, Eugene V ; Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK ; Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK ; Mellanby Centre for Musculoskeletal Research, MRC Versus Arthritis Centre for Integrated Research in Musculoskeletal Ageing, University of Sheffield, Sheffield, UK
Board of IOF, and the IOF Working Group on Epidemiology and Quality of Life
Race-specific FRAX models are evidence-based and support equitable care: a response to the ASBMR Task Force report on Clinical Algorithms for Fracture Risk.
Publication date :
September 2024
Journal title :
Osteoporosis International
ISSN :
0937-941X
eISSN :
1433-2965
Publisher :
Springer Science and Business Media Deutschland GmbH, England
We are grateful to the Board of the\u00A0International Osteoporosis Foundation (IOF) and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) for their endorsement of this position paper. The Epidemiology and Quality of Life Working Group comprises: Bo Abrahamsen, JD Adachi, Fredrik Borgstrom, Olivier Bruy\u00E8re, John J Carey, Patricia Clark, Cyrus Cooper, Elizabeth Curtis, Elaine Dennison, Manuel Diaz-Curiel, Hans P Dimai, Celia L Gregson, Daniel Grigorie, Nicholas C Harvey, Mickael Hiligsmann, Helena Johansson, John A Kanis (chair), Patricia Khashayar, Edith Lau, Willem Lems, E Michael Lewiecki, Roman S Lorenc, Paul Lips, Mattias Lorentzon, Eugene V McCloskey, Sergio Ortolani, Alexandra Papaioannou, Jean-Yves Reginster, Stuart Silverman, Manuel Sosa Henr\u00EDquez, Pawel Szulc, Kate Ward and Noriko Yoshimura. The Board of the IOF comprise Nicholas C Harvey (President), Cyrus Cooper, Bess Dawson-Hughes, Famida Jiwa, John A Kanis, Eugene V McCloskey, Jean-Yves Reginster, Rene Rizzoli and the following regional representatives: Africa Ter\u00E9za Hough (South Africa) Abdellah El Maghraoui (Morocco) Ngozi Rosemary Njeze (Nigeria) Leith Zakraoui (Tunisia) Asia-Pacific Manju Chandran (Singapore) Peter Ebeling (Australia) Ambrish Mithal (India) Atsushi Suzuki (Japan) Europe Maria Luisa Brandi (Italy) Olivier Bruy\u00E8re (Belgium) Nicholas Harvey (UK), IOF President Radmila Matijevic (Serbia) Latin America Claudia Campusano (Chile) Patricia Clark (Mexico) Osvaldo Daniel Messina (Argentina) Jorge Luis Alberto Morales Torres (Mexico) Middle-East Nizar Abdulateef (Iraq) Bagher Larijani (Iran) Basel K Masri (Jordan) Youssef Saleh (Saudi Arabia) North America Bess Dawson-Hughes (USA) Michael McClung (USA) Daniel Pinto (USA) Stuart L Silverman (USA)M Schini received funding for her fellowship from the Medical Research Council Centre of Excellence for Musculoskeletal Ageing, from the Osteoporosis 2000 support group and from Roche Diagnostics and honoraria from MA Health care and Kyowa Kirin\u2014all unrelated to this work.B Abrahamsen has received consultancy/lecture fees/institutional grant funding from UCB, Amgen, Pharmacosmos, Kyowa-Kirin and Gedeon-Richter outside the current work.
S.-A.M. Burnett-Bowie N.C. Wright E.W. Yu L. Langsetmo G.M.H. Yearwood C.J. Crandall W.D. Leslie J.A. Cauley The American Society for Bone and Mineral Research Task Force on clinical algorithms for fracture risk report J Bone Miner Res 2024 9 zjae048 10.1093/jbmr/zjae048
D.A. Vyas L.G. Eisenstein D.S. Jones Hidden in plain sight—reconsidering the use of race correction in clinical algorithms N Engl J Med 2020 383 874 882 32853499 10.1056/NEJMms2004740
A. Flanagin T. Frey S.L. Christiansen AMA Manual of Style Committee Updated guidance on the reporting of race and ethnicity in medical and science journals JAMA 2021 326 621 627 34402850 10.1001/jama.2021.13304
H.W. Reid B. Selvan B.C. Batch R.H. Lee The break in FRAX: equity concerns in estimating fracture risk in racial and ethnic minorities J Am Geriatr Soc 2021 69 2692 2695 34124772 9976214 10.1111/jgs.17316 Erratum in: J Am Geriatr Soc. 2021 Oct 14
R.K. Jain M. Weiner E. Polley A. Iwamaye E. Huang T. Vokes Electronic health records (EHRs) can identify patients at high risk of fracture but require substantial race adjustments to currently available fracture risk calculators J Gen Intern Med 2023 38 3451 3459 37715097 10.1007/s11606-023-08347-5
E.M. Lewiecki N.C. Wright A.J. Singer Racial disparities FRAX, and the care of patients with osteoporosis Osteoporos Int 2020 31 2069 2071 1:STN:280:DC%2BB3s%2FjvFelsw%3D%3D 32980922 7938336 10.1007/s00198-020-05655-y
J.A. Kanis C. Cooper B. Dawson-Hughes N.C. Harvey H. Johansson M. Lorentzon E.V. McCloskey J.-Y. Reginster R. Rizzoli FRAX and ethnicity Osteoporos Int 2020 31 2063 2067 1:STN:280:DC%2BB38bks1yqsg%3D%3D 32888046 7116478 10.1007/s00198-020-05631-6
E. Barrett-Connor E.S. Siris L.E. Wehren P.D. Miller T.A. Abbott M.L. Berger A.C. Santora L.M. Sherwood Osteoporosis and fracture risk in women of different ethnic groups J Bone Miner Res 2005 20 185 194 15647811 10.1359/JBMR.041007
Dawson-Hughes B, Cosman F, McClung M (2024) The American Society for Bone and Mineral Research Task Force on clinical algorithms for fracture risk report. J Bone Miner Res in press
R. Dhaliwal R.I. Pereira A.M. Diaz-Thomas C.E. Powe L.L. Yanes Cardozo J.J. Joseph Eradicating racism: an endocrine society policy perspective J Clin Endocrinol Metab 2022 107 1205 1215 35026013 10.1210/clinem/dgab896
S.E. Noel M.P. Santos N.C. Wright Racial and ethnic disparities in bone health and outcomes in the United States J Bone Miner Res 2021 36 1881 1905 34338355 10.1002/jbmr.4417
S.E. Kellie J.A. Brody Sex-specific and race-specific hip fracture rates Am J Public Health 1990 80 326 328 1:STN:280:DyaK3c7msVyhsg%3D%3D 2305917 1404674 10.2105/AJPH.80.3.326
J.A. Cauley L. Wu N.S. Wampler J.M. Barnhart M. Allison Z. Chen R. Jackson J. Robbins Clinical risk factors for fractures in multi-ethnic women: the Women’s Health Initiative J Bone Miner Res 2007 22 1816 1826 17638574 10.1359/jbmr.070713
N.C. Wright K.G. Saag J.R. Curtis W.K. Smith M.L. Kilgore M.A. Morrisey H. Yun J. Zhang E.S. Delzell Recent trends in hip fracture rates by race/ethnicity among older US adults J Bone Miner Res 2012 27 2325 2332 22692958 10.1002/jbmr.1684
H.A. Fink M.E. Butler A.M. Claussen E.S. Collins K.M. Krohn B.C. Taylor S.S. Tikabo D. Vang N.L. Zerzan K.E. Ensrud Performance of fracture risk assessment tools by race and ethnicity: a systematic review for the ASBMR Task Force on clinical algorithms for fracture risk J Bone Miner Res 2023 38 1731 1741 37597237 10.1002/jbmr.4895
A.C. Looker L.J. Melton 3rd L.G. Borrud J.A. Shepherd Changes in femur neck bone density in US adults between 1988–1994 and 2005–2008: demographic patterns and possible determinants Osteoporos Int 2012 23 771 780 1:STN:280:DC%2BC387ls1Ogtw%3D%3D 21625885 10.1007/s00198-011-1623-0
J.A. Cauley L.Y. Lui K.E. Ensrud J.M. Zmuda K.L. Stone M.C. Hochberg S.R. Cummings Bone mineral density and the risk of incident nonspinal fractures in black and white women JAMA 2005 293 2102 2108 1:CAS:528:DC%2BD2MXjvFGqt7g%3D 15870413 10.1001/jama.293.17.2102
O. Johnell F. Borgstrom B. Jonsson J. Kanis Latitude, socioeconomic prosperity, mobile phones and hip fracture risk Osteoporos Int 2007 18 333 337 1:STN:280:DC%2BD2s%2FoslOmsw%3D%3D 17077942 10.1007/s00198-006-0245-4
J.A. Kanis A. Odén E.V. McCloskey H. Johansson D. Wahl C. Cyrus Cooper on behalf of the IOF Working Group on Epidemiology and Quality of Life A systematic review of hip fracture incidence and probability of fracture worldwide Osteoporos Int 2012 23 2239 2256 1:STN:280:DC%2BC38vmvVCksw%3D%3D 22419370 3421108 10.1007/s00198-012-1964-3
C.J. Crandall J. Larson A. LaCroix J.A. Cauley M.S. LeBoff W. Li E.S. LeBlanc B.J. Edwards J.E. Manson K. Ensrud Predicting fracture risk in younger postmenopausal women: comparison of the Garvan and FRAX risk calculators in the Women’s Health Initiative study J Gen Intern Med 2019 34 235 242 30334182 10.1007/s11606-018-4696-z
C.J. Crandall J. Larson J.A. Cauley J.T. Schousboe A.Z. LaCroix J.A. Robbins N.B. Watts K.E. Ensrud Do additional clinical risk factors improve the performance of Fracture Risk Assessment Tool (FRAX) among postmenopausal women? Findings From the Women’s Health Initiative observational study and clinical trials JBMR Plus 2019 3 12 e10239 10.1002/jbm4.10239 31844827 6894725
J.A. Kanis A. Oden H. Johansson E. McCloskey Pitfalls in the external validation of FRAX Osteoporos Int 2012 23 423 431 1:STN:280:DC%2BC387lslGlsw%3D%3D 22120907 10.1007/s00198-011-1846-0
M. Visser S.B. Kritchevsky B.H. Goodpaster A.B. Newman M. Nevitt E. Stamm T.B. Harris Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: the health, aging and body composition study J Am Geriatr Soc 2002 50 897 904 12028178 10.1046/j.1532-5415.2002.50217.x
M. Kebaetse S. Nkhwa M. Mogodi J. Masunge Y.P. Gureja M. Ramabu T. Mmopelwa I. Sharif A. Orford N.C. Harvey E.V. McCloskey J.A. Cauley J.A. Kanis H. Johansson A country-specific FRAX model for Botswana Arch Osteoporos 2021 16 1 90 1:STN:280:DC%2BB2c7lsVKqtA%3D%3D 10.1007/s11657-021-00965-y 34100118 8184541
H. Johansson A. Odén M. Lorentzon E. McCloskey J.A. Kanis N.C. Harvey M.K. Karlsson D. Mellström Is the Swedish FRAX model appropriate for Swedish immigrants? Osteoporos Int 2015 26 2617 2622 1:STN:280:DC%2BC2MfnvFentQ%3D%3D 26018091 10.1007/s00198-015-3180-4
Institute of Medicine (US) Committee on Understanding and Eliminating Racial and Ethnic Disparities in Health Care (2003) Unequal treatment: confronting racial and ethnic disparities in health care. In: Smedley BD, Stith AY, Nelson AR (editors). Washington (DC): National Academies Press (US)
N.C. Wright L. Chen K.G. Saag C.J. Brown J.M. Shikany J.R. Curtis Racial disparities exist in outcomes after major fragility fractures J Am Geriatr Soc 2020 68 1803 1810 32337717 7935465 10.1111/jgs.16455
J.C. Lo R.L. Hui C.D. Grimsrud M. Chandra R.S. Neugebauer J.R. Gonzalez A. Budayr G. Lau B. Ettinger The association of race/ethnicity and risk of atypical femur fracture among older women receiving oral bisphosphonate therapy Bone 2016 85 142 147 26769007 5108728 10.1016/j.bone.2016.01.002
J.C. Lo S.Y. Huang G.A. Lee S. Khandelwal J. Provus B. Ettinger J.R. Gonzalez R.L. Hui C.D. Grimsrud Clinical correlates of atypical femoral fracture Bone 2012 51 181 184 22414379 10.1016/j.bone.2012.02.632
D.M. Black E.J. Geiger R. Eastell E. Vittinghoff B.H. Li D.S. Ryan R.M. Dell A.L. Adams Atypical femur fracture risk versus fragility fracture prevention with bisphosphonates N Engl J Med 2020 383 743 753 1:CAS:528:DC%2BB3cXhs1GlsbfK 32813950 9632334 10.1056/NEJMoa1916525
H.H. Nguyen A. Lakhani C. Shore-Lorenti R. Zebaze A.J. Vincent F. Milat P.R. Ebeling Asian ethnicity is associated with atypical femur fractures in an Australian population study Bone 2020 135 115319 1:CAS:528:DC%2BB3cXosVWqsb8%3D 10.1016/j.bone.2020.115319 32179169
M.S. LeBoff S.L. Greenspan K.L. Insogna E.M. Lewiecki K.G. Saag A.J. Singer E.S. Siris The clinician's guide to prevention and treatment of osteoporosis Osteoporos Int 2022 33 2049 2102 1:STN:280:DC%2BB2MrivFWnuw%3D%3D 35478046 9546973 10.1007/s00198-021-05900-y
J.A. Kanis M. Chandran S.B. Chionh G. Ganeson N.C. Harvey W.P. Koh T. Kwok T.C. Lau E. Liu M. Lorentzon E.V. McCloskey K.B. Tan L. Vandenput H. Johansson Use of age-dependent FRAX-based intervention thresholds for Singapore Arch Osteoporos 2020 15 1 104 10.1007/s11657-020-00782-9 32700118 7376084
M. Chandran E.V. McCloskey W.P.P. Thu S. Logan Y. Hao D. Tay W.C. Ang T.K.K. Aung K.S. Choo A. Ali S.X. Yan X.F. Huang X.M. Liu E.L. Yong FRAX® based intervention thresholds for management of osteoporosis in Singaporean women Arch Osteoporos 2018 13 1 130 1:STN:280:DC%2BB3crivVeltw%3D%3D 10.1007/s11657-018-0542-5 30456726
J.A. Kanis C. Cooper R. Rizzoli J.-Y. Reginster Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO) and the Committees of Scientific Advisors and National Societies of the International Osteoporosis Foundation (IOF) European guidance for the diagnosis and management of osteoporosis in postmenopausal women Osteoporos Int 2019 30 3 44 1:STN:280:DC%2BB3czps1KrsQ%3D%3D 30324412 10.1007/s00198-018-4704-5
P. Clark E. Denova-Gutiérrez C. Zerbini A. Sanchez O. Messina J.J. Jaller C. Campusano C.H. Orces G. Riera H. Johansson J.A. Kanis FRAX-based intervention and assessment thresholds in seven Latin American countries Osteoporos Int 2018 29 707 715 1:STN:280:DC%2BC1MzkslGjtQ%3D%3D 29273826 10.1007/s00198-017-4341-4
O. Lesnyak A. Zakroyeva V. Babalyan V. Cazac G. Gabdulina S. Ismailov O. Lobanchenko E. Rudenka M. Tsagareli H. Johansson N.C. Harvey E. McCloskey J.A. Kanis FRAX-based intervention thresholds in eight Eurasian countries: Armenia, Belarus, Georgia, Kazakhstan, the Kyrgyz Republic, Moldova, the Russian Federation, and Uzbekistan Arch Osteoporos 2021 16 1 87 10.1007/s11657-021-00962-1 34089424
A. Naseri M. Bakhshayeshkaram S. Salehi S.T. Heydari M.H. Dabbaghmanesh M.M. Dabbaghmanesh FRAX-derived intervention and assessment thresholds for osteoporosis in ten Middle Eastern Countries Arch Osteoporos 2024 19 1 41 10.1007/s11657-024-01397-0 38780743
J.A. Kanis N.C. Harvey C. Cooper H. Johansson A. Oden E.V. McCloskey The Advisory Board of the National Osteoporosis Guideline Group A systematic review of intervention thresholds based on FRAX. A report prepared for the National Osteoporosis Guideline Group and the International Osteoporosis Foundation Arch Osteoporos 2016 11 25 10.1007/s11657-016-0278-z 27465509 4978487
J. Ratnasingam M. Niyaz S. Mariyappan T. Ong S.P. Chan F.L. Hew S.S. Yeap S. Velaiutham S.C. Thambiah S. Lekamwasam Age-dependent FRAX-based assessment and intervention thresholds for therapeutic decision making in osteoporosis in the Malaysian population Arch Osteoporos 2024 19 18 10.1007/s11657-024-01371-w 38503995
Johansson H, Kwang YC, Chandran M, Schini M, Liu E, Lorentzon M, Vandenput L, Harvey NC, McCloskey E, Kanis JA (2024) A surrogate FRAX model for Brunei. Aging Clin Exp Res, in press.
H. Johansson S.S. Dela B. Cassim F. Paruk S.L. Brown M. Conradie N.C. Harvey J.D. Jordaan A.A. Kalla E. Liu M. Lorentzon M. Lukhele E.V. McCloskey O. Mohamed P. Chutterpaul L. Vandenput J.A. Kanis FRAX-based fracture probabilities in South Africa Arch Osteoporos 2021 16 51 10.1007/s11657-021-00905-w 33649966 7921059
V.L. Bonham S.L. Sellers T.H. Gallagher D. Frank A.O. Odunlami E.G. Price L.A. Cooper Physicians’ attitudes toward race, genetics, and clinical medicine Genet Med 2009 11 279 286 19265721 3065019 10.1097/GIM.0b013e318195aaf4
X. Xiao Q. Wu The utility of genetic risk score to improve performance of FRAX for fracture prediction in US postmenopausal women Calcif Tissue Int 2021 108 746 756 1:CAS:528:DC%2BB3MXjsF2gur8%3D 33560447 8169615 10.1007/s00223-021-00809-4
V. Forgetta J. Keller-Baruch M. Forest A. Durand S. Bhatnagar J. Kemp M. Nethander D. Evans J.A. Morris D.P. Kiel F. Rivadeneira H. Johannson N. Harvey D. Mellström M. Karlsson C. Cooper D.M. Evans R. Clark J.A. Kanis E. Orwoll E.V. McCloskey C. Ohlsson J. Pineau W.D. Leslie C.M.T. Greenwood J.B. Richards Development of a polygenic risk score to improve screening for fracture risk: a genetic risk prediction study PLoS Med 2020 17 e1003152 10.1371/journal.pmed.1003152 32614825 7331983
T. Lu V. Forgetta J. Keller-Baruch M. Nethander D. Bennett M. Forest S. Bhatnagar R.G. Walters K. Lin Z. Chen L. Li M. Karlsson D. Mellström E. Orwoll E.V. McCloskey J.A. Kanis W.D. Leslie R.J. Clarke C. Ohlsson C.M.T. Greenwood J.B. Richards Improved prediction of fracture risk leveraging a genome-wide polygenic risk score Genome Med 2021 13 1 16 1:CAS:528:DC%2BB3MXhtVOrtb3K 10.1186/s13073-021-00838-6 33536041 7860212
M. Nethander U. Pettersson-Kymmer L. Vandenput M. Lorentzon M. Karlsson D. Mellström C. Ohlsson BMD-related genetic risk scores predict site-specific fractures as well as trabecular and cortical bone microstructure J Clin Endocrinol Metab 2020 105 4 e1344 e1357 10.1210/clinem/dgaa082 32067027 7069346
R.E. Popham W. Schmidt Words and deeds: the validity of self-report data on alcohol consumption J Stud Alcohol 1981 42 355 368 1:STN:280:DyaL38%2FhtF2ktA%3D%3D 7278280 10.15288/jsa.1981.42.355
C.G. Watson C. Tilleskjor E.A. Hoodecheck-Schow J. Pucel L. Jacobs Do alcoholics give valid self-reports? J Stud Alcohol 1984 45 344 348 1:STN:280:DyaL2M%2FhtFahug%3D%3D 6482438 10.15288/jsa.1984.45.344
J.A. Kanis H. Johansson O. Johnell A. Oden C. De Laet J.A. Eisman H. Pols A. Tenenhouse Alcohol intake as a risk factor for fracture Osteoporos Int 2005 16 737 742 15455194 10.1007/s00198-004-1734-y
M. Schini H. Johansson N.C. Harvey M. Lorentzon J.A. Kanis E.V. McCloskey An overview of the use of the Fracture Risk Assessment Tool (FRAX) in osteoporosis J Endocrinol Invest 2023 47 501 511 37874461 10904566 10.1007/s40618-023-02219-9
Kanis JA on behalf of the World Health Organization Scientific Group (2007) Assessment of osteoporosis at the primary health-care level. In: Tech Rep. Sheffield, UK: World Health Organization Collaborating Centre for Metabolic Bone Diseases
J.A. Kanis A. Oden O. Johnell H. Johansson C. De Laet J. Brown P. Burckhardt C. Cooper C. Christiansen S. Cummings J.A. Eisman S. Fujiwara C. Glüer D. Goltzman D. Hans M.-A. Krieg A. La Croix E. McCloskey D. Mellstrom L.J. Melton H. Pols J. Reeve K. Sanders A.-M. Schott A. Silman D. Torgerson T. van Staa N.B. Watts N. Yoshimura The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women Osteoporos Int 2007 18 1033 1046 1:STN:280:DC%2BD2sznvV2hug%3D%3D 17323110 10.1007/s00198-007-0343-y
R.T. Chlebowski G.L. Anderson D.S. Lane A.K. Aragaki T. Rohan S. Yasmeen G. Sarto C.A. Rosenberg F.A. Hubbell Women’s Health Initiative Investigators Predicting risk of breast cancer in postmenopausal women by hormone receptor status J Natl Cancer Inst 2007 99 22 1695 705 1:CAS:528:DC%2BD1cXkslyksA%3D%3D 18000216 10.1093/jnci/djm224
I. Goldshtein Y. Gerber S. Ish-Shalom M. Leshno Fracture risk assessment with FRAX using real-world data in a population-based cohort from Israel Am J Epidemiol 2018 187 94 102 28520844 10.1093/aje/kwx128
J. Hippisley-Cox C. Coupland Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractures Scores Br Med J 2009 339 b4229 10.1136/bmj.b4229
W.D. Leslie L.M. Lix H. Johansson A. Odén E. McCloskey J.A. Kanis Independent clinical validation of a Canadian FRAX tool: fracture prediction and model calibration J Bone Miner Res 2010 25 2350 2358 20499367 10.1002/jbmr.123
M. Hoff H.E. Meyer S. Skurtveit A. Langhammer A.J. Søgaard U. Syversen A. Dhainaut E. Skovlund B. Abrahamsen B. Schei Validation of FRAX and the impact of self-reported falls among elderly in a general population: the HUNT study, Norway Osteoporos Int 2017 28 2935 2944 1:STN:280:DC%2BC1cjjslSmtQ%3D%3D 28668994 10.1007/s00198-017-4134-9
I.T. Liu F.W. Liang C.C. Li Y.F. Chang Z.J. Sun T.H. Lu C.S. Chang C.H. Wu Validation of the Taiwan FRAX® calculator for the prediction of fracture risk Arch Osteoporos 2022 17 1 27 1:CAS:528:DC%2BB38XjvFWrsbg%3D 10.1007/s11657-022-01068-y 35094177
G. Xu N. Yamamoto K. Hayashi A. Takeuchi S. Miwa K. Igarashi Y. Taniguchi Y. Araki H. Yonezawa S. Morinaga H. Tsuchiya The accuracy of different FRAX tools in predicting fracture risk in Japan: a comparison study J Orthop Surg (Hong Kong) 2020 28 2309499020917276 10.1177/2309499020917276 32336240
J. Mousa M.N. Peterson C.S. Crowson S.J. Achenbach E.J. Atkinson S. Amin S. Khosla J.M. Davis 3rd E. Myasoedova Validating the Fracture Risk Assessment Tool Score in a US population-based study of patients with rheumatoid arthritis J Rheumatol 2023 50 1279 1286 37399469 10.3899/jrheum.2022-1293
N. Dagan C. Cohen-Stavi M. Leventer-Roberts R.D. Balicer External validation and comparison of three prediction tools for risk of osteoporotic fractures using data from population based electronic health records: retrospective cohort study BMJ 2017 356 i6755 10.1136/bmj.i6755 28104610 5244817
J.A. Kanis H. Johansson E.V. McCloskey E. Liu K.E. Åkesson F.A. Anderson R. Azagra C.L. Bager C. Beaudart H.A. Bischoff-Ferrari E. Biver O. Bruyère J.A. Cauley J.R. Center R. Chapurlat C. Christiansen C. Cooper C.J. Crandall S.R. Cummings J.A.P. da Silva B. Dawson-Hughes A. Diez-Perez A.B. Dufour J.A. Eisman P.J.M. Elders S. Ferrari Y. Fujita S. Fujiwara C.C. Glüer I. Goldshtein D. Goltzman V. Gudnason J. Hall D. Hans M. Hoff R.J. Hollick M. Huisman M. Iki S. Ish-Shalom G. Jones M.K. Karlsson S. Khosla D.P. Kiel W.P. Koh F. Koromani M.A. Kotowicz H. Kröger T. Kwok O. Lamy A. Langhammer B. Larijani K. Lippuner D. Mellström T. Merlijn A. Nordström P. Nordström T.W. O'Neill B. Obermayer-Pietsch C. Ohlsson E.S. Orwoll J.A. Pasco F. Rivadeneira A.M. Schott E.J. Shiroma K. Siggeirsdottir E.M. Simonsick E. Sornay-Rendu R. Sund K.M.A. Swart P. Szulc J. Tamaki D.J. Torgerson N.M. van Schoor T.P. van Staa J. Vila N.J. Wareham N.C. Wright N. Yoshimura M.C. Zillikens M. Zwart L. Vandenput N.C. Harvey M. Lorentzon W.D. Leslie Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX Osteoporos Int 2023 34 2027 2045 1:STN:280:DC%2BB2snhsValtQ%3D%3D 37566158 7615305 10.1007/s00198-023-06870-z
L. Vandenput H. Johansson E.V. McCloskey E. Liu K.E. Åkesson F.A. Anderson R. Azagra C.L. Bager C. Beaudart H.A. Bischoff-Ferrari E. Biver O. Bruyère J.A. Cauley J.R. Center R. Chapurlat C. Christiansen C. Cooper C.J. Crandall S.R.S. Cumming J.A.P. da Silva B. Dawson-Hughes A. Diez-Perez A.B. Dufour J.A. Eisman P.J.M. Elders S. Ferrari Y. Fujita S. Fujiwara C.-C. Glüer I. Goldshtein D. Goltzman V. Gudnason J. Hall D. Hans M. Hoff R.J. Hollick M. Huisman M. Iki S. Ish-Shalom G. Jones M.K. Karlsson S. Khosla D.P. Kiel W.-P. Koh F. Koromani M.A. Kotowicz H. Kröger T. Kwok O. Lamy A. Langhammer B. Larijani K. Lippuner D. Mellström T. Merlijn A. Nordström P. Nordström T.W. O’Neill B. Obermayer-Pietsch C. Ohlsson E.S. Orwoll J.A. Pasco F. Rivadeneira B. Schei A.-M. Schott K. Siggeirsdottir E.M. Simonsick E. Sornay-Rendu R. Sund K.M.A. Swart P. Szulc J. Tamaki D.J. Torgerson N.M. van Schoor T.P. van Staa J. Vila N.J. Wareham N.C. Wright N. Yoshimura M.C. Zillikens M. Zwart N.C. Harvey M. Lorentzon W.D. Draft Leslie J.A. Kanis A meta-analysis of previous falls and subsequent fracture risk Osteoporos Int 2022 35 469 494 10.1007/s00198-023-07012-1
J.A. Kanis D. Hans C. Cooper S. Baim J.P. Bilezikian N. Binkley J. Compston B. Dawson-Hughes G. El-Hajj Fuleihan H. Johansson W.D. Leslie E.M. Lewiecki M.M. Luckey A. Oden S.E. Papapoulos C. Poiana D.A. Wahl E. McCloskey the Task Force of the FRAX Initiative Interpretation and use of FRAX in clinical practice Osteoporos Int 2011 22 395 411 10.1007/s00198-011-1713-z
Tipton K, Leas BF, Flores E, Jepson C, Aysola J, Cohen J, Harhay M, Schmidt H, Weissman G, Treadwell J, Mull NK, Siddique SM (2023) Impact of healthcare algorithms on racial and ethnic disparities in health and healthcare [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); Report No.: 24-EHC004
A. Mafi H. Naqvi V. L'Esperance Taking racism out of clinical guidelines BMJ 2024 30 385 q942 10.1136/bmj.q942
