Guidelines for the correct use of the nomenclature of biochemical indices of bone status: a position statement of the Joint IOF Working Group and IFCC Committee on Bone Metabolism.
Lombardi, Giovanni; Jørgensen Rye, Niklas; Harvey, Nicholas Cet al.
2024 • In Clinical Chemistry and Laboratory Medicine
Guidelines for the correct use of the nomenclature of biochemical indices of bone status - a position statement of the Joint IOF Working Group and IFCC Committe.pdf
bone status indices; nomenclature; standardization
Abstract :
[en] The presented guidelines are an update of the position paper, endorsed by the International Osteoporosis Foundation (IOF), on nomenclature of bone markers published over 2 decades ago. Novel insight into bone biology and pathophysiology of bone disorders has highlighted the increasing relevance of new and known mediators implicated in various aspects of bone metabolism. This updated guideline proposes the nomenclature Bone Status Indices (BSI) as the comprehensive classification rather than bone turnover markers, bone markers, metabolic markers of bone turnover or metabolic markers of bone turnover, that are currently in use for the implicated molecules. On behalf of the IFCC Committee on Bone Metabolism and the Joint IOF Working Group and IFCC Committee on Bone Metabolism, the authors propose standardized nomenclature, abbreviations and measurement units for the bone status indices.
Disciplines :
Laboratory medicine & medical technology Rheumatology Endocrinology, metabolism & nutrition
Author, co-author :
Lombardi, Giovanni ; Laboratory of Experimental Biochemistry, IRCCS Ospedale Galeazzi-Sant'Ambrogio, Milan, Italy ; Department of Athletics, Strength and Conditioning, Poznań University of Physical Education, Poznań, Poland
Jørgensen Rye, Niklas ; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark ; Faculty of Health and Medical Sciences, Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
Harvey, Nicholas C ; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK ; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK
McCloskey, Eugene V ; Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK ; Mellanby Centre for Musculoskeletal Research, MRC Versus Arthritis Centre for Integrated Research in Musculoskeletal Ageing, University of Sheffield, Sheffield, UK ; Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK
Åkesson, Kristina E ; Department of Clinical Sciences, Clinical and Molecular Osteoporosis Research Unit, Lund University, Malmö, Sweden ; Department of Orthopaedics, Skåne University Hospital, Malmö, Sweden
Eastell, Richard ; Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK
Garnero, Patrick ; INSERM Unit 1033, Edouard Herriot Hospital, Lyon, France
Kanis, John A ; Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK ; Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia
Khashayar, Patricia ; International Institute for Biosensing, University of Minnesota, Minneapolis, USA
Lane, Nancy E; Department of Medicine, Division of Rheumatology, U.C. Davis Health, Sacramento, CA, USA
McClung, Michael R ; Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia ; Oregon Osteoporosis Center, Portland, OR, USA
Silverman, Stuart ; Cedars-Sinai Medical Center and Geffen School of Medicine UCLA, Los Angeles, CA, USA
Makris, Konstantinos ; Clinical Biochemistry Department, KAT General Hospital, Kifissia, Athens, Greece ; Laboratory for the Research of Musculoskeletal System "Th. Garofalidis", School of Medicine, National and Kapodistrian, University of Athens, Athens, Greece
Bhattoa, Harjit Pal ; Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Vasikaran, Samuel D ; PathWest Laboratory Medicine, Fiona Stanley Hospital, Murdoch, WA, Australia
Pikner, Richard ; Department of Clinical Biochemistry and Bone Metabolism, Klatovska Hospital, Klatovy, Czech Republic ; Department of Clinical Biochemistry and Haematology, Faculty of Medicine Pilsen, Charles University Prague, Pilsen, Czech Republic ; Faculty of Health Care Studies, University of West Bohemia, Pilsen, Czech Republic
Cavalier, Etienne ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Guidelines for the correct use of the nomenclature of biochemical indices of bone status: a position statement of the Joint IOF Working Group and IFCC Committee on Bone Metabolism.
Delmas PD, Eastell R, Garnero P, Seibel MJ, Stepan J, Committee of Scientific Advisors of the International Osteoporosis Foundation. The use of biochemical markers of bone turnover in osteoporosis. Osteoporos Int 2000;11:S2–17.
Delmas PD. Committee of scientific advisors of the international osteoporosis. Bone marker nomenclature. Bone 2001;28:575–6.
Delmas PD. Standardization of bone marker nomenclature. Clin Chem 2001;47:1497.
Lombardi G, Perego S, Luzi L, Banfi G. A four-season molecule: osteocalcin. Updates in its physiological roles. Endocrine 2015;48:394–404.
Ladang A, Rauch F, Delvin E, Cavalier E. Bone turnover markers in children: from laboratory challenges to clinical interpretation. Calcif Tissue Int 2023;112:218–32.
Cremers S, Garnero P, Seibel MJ. Chapter 87 – biochemical markers of bone metabolism. In: Bilezikian JP, Raisz LG, Martin TJ, editors. Principles of Bone Biology. 3rd ed. San Diego: Academic Press; 2008:1857–81 pp.
Glendenning P, Chubb SAP, Vasikaran SD. Clinical utility of bone turnover markers in the management of common metabolic bone diseases in adults. Clin Chim Acta 2018;481:161–70.
Vasikaran SD, Miura M, Pikner R, Bhattoa HP, Cavalier E. Practical considerations for the clinical application of bone turnover markers in osteoporosis. Calcif Tiusse Int 2023;112:148–57.
Garnero P. The contribution of collagen crosslinks to bone strength. BoneKEy Rep 2012;1:182.
Garnero P, Ferreras M, Karsdal MA, Nicamhlaoibh R, Risteli J, Borel O, et al. The type I collagen fragments ICTP and CTX reveal distinct enzymatic pathways of bone collagen degradation. J Bone Miner Res 2023;18:859–67.
Cavalier E, Souberbielle JC, Gadisseur R, Dubois B, Krzesinski JM, Delanaye P. Inter-method variability in bone alkaline phosphatase measurement: clinical impact on the management of dialysis patients. Clin Biochem 2014;47:1227–30.
Hansen YBL. Recommendations on measurement units – why and how. Eur J IFCC 2019;30:250–75.
Alonso N, Zelzer S, Eibinger G, Herrmann M. Vitamin D metabolites: analytical challenges and clinical relevance. Calcif Tissue Int 2023;112: 158–77.
Tang JCY, Jackson S, Walsh NP, Greeves J, Fraser WD, Ball N, et al. Bioanalytical Facility team. The dynamic relationships between the active and catabolic vitamin D metabolites, their ratios, and associations with PTH. Sci Rep 2019;9:6974.
Dugar A, Hoofnagle AN, Sanchez AP, Ward DM, Corey-Bloom J, Cheng JH, et al. The vitamin D metabolite ratio (VMR) is a biomarker of vitamin D status that is not affected by acute changes in vitamin D binding protein. Clin Chem 2023;69:718–23.
Cavalier E, Fraser CG, Bhattoa HP, Heijboer AC, Makris K, Vasikaran S, et al. the IFCC-IOF Committee for Bone Metabolism. Analytical performance specifications for the measurement uncertainty of 24,25-dihydroxyvitamin D examinations. Clin Chem Lab Med 2023;61: 1561–6.
