Unravelling metabolic factors impacting iNKT cell biology in obesity.

CD1d; Free fatty acids; Immunometabolism; Lipid; Obesity; iNKT cells; Cytokines; Adipokines; Humans; Animals; Cytokines/metabolism; Cytokines/immunology; Adipokines/metabolism; Adipokines/immunology; Obesity/metabolism; Obesity/immunology; Natural Killer T-Cells/immunology; Natural Killer T-Cells/metabolism; Natural Killer T-Cells; Biochemistry; Pharmacology

Abstract :

[en] Obesity and related diseases have reached epidemic proportions and continue to rise. Beyond creating an economical burden, obesity and its co-morbidities are associated with shortened human life expectancy. Despite major advances, the underlying mechanisms of obesity remain not fully elucidated. Recently, several studies have highlighted that various immune cells are metabolically reprogrammed in obesity, thereby profoundly affecting the immune system. This sheds light on a new field of interest: the impact of obesity-related systemic metabolic changes affecting immune system that could lead to immunosurveillance loss. Among immune cells altered by obesity, invariant Natural Killer T (iNKT) cells have recently garnered intense focus due to their ability to recognize lipid antigen. While iNKT cells are well-described to be affected by obesity, how and to what extent immunometabolic factors (e.g., lipids, glucose, cytokines, adipokines, insulin and free fatty acids) can drive iNKT cells alterations remains unclear, but represent an emerging field of research. Here, we review the current knowledge on iNKT cells in obesity and discuss the immunometabolic factors that could modulate their phenotype and activity.

Disciplines :

Immunology & infectious disease

Author, co-author :

Wilkin, Chloé ; Université de Liège - ULiège > GIGA

Piette, Jacques ; Université de Liège - ULiège > GIGA > GIGA I3 - Virology and Immunology

Legrand, Sylvie ; Université de Liège - ULiège > GIGA > GIGA I3 - Immunometabolism and Nutrition

Language :

English

Title :

Unravelling metabolic factors impacting iNKT cell biology in obesity.

Publication date :

October 2024

Journal title :

Biochemical Pharmacology

ISSN :

0006-2952

eISSN :

1873-2968

Publisher :

Elsevier Inc., England

Volume :

228

Pages :

116436

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S0006295224004192?httpAccept=text/xml

Funders :

Leon Fredericq Foundation
F.R.S.-FNRS - Fonds de la Recherche Scientifique

Funding text :

We thank Bartimée Galvan (University Children's Hospital Zurich, Switzerland) for comments on the manuscript. This work was supported by Belgian F.R.S.-FNRS, the T\u00E9l\u00E9vie and the Leon Fredericq funds for Biomedical Research from the University of Liege, Belgium.

Available on ORBi :

since 22 November 2024

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