[en] When used separately, virtual reality (VR) and mind-body therapies (MBTs) have the potential to reduce pain across various acute and chronic conditions. While their combination is increasingly used, no study offers a consolidated presentation of VR and MBTs. This study aims to propose an overview of the effectiveness of VR combined with MBTs (i.e., meditation, mindfulness, relaxation, and hypnosis) to decrease the pain experienced by healthy volunteers or patients. We conducted a scoping review of the literature using PubMed, Science Direct and Google Scholar and included 43 studies. Findings across studies support that VR combined with MBTs is a feasible, well-tolerated, and potentially useful to reduce pain. Their combination also had a positive effect on anxiety, mood, and relaxation. However, insufficient research on this VR/MBTs combination and the lack of multidimensional studies impede a comprehensive understanding of their full potential. More randomized controlled studies are thus needed, with usability evaluation protocols to better understand the effects of VR/MBTs on patients wellbeing and to incorporate them into routine clinical practice.
Disciplines :
Alternative medicine
Author, co-author :
Louras, Mélanie ; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group
Panda, Rajanikant ; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; Coma Neuroscience Lab, Department of Neurology, University of California San Francisco, San Francisco, USA
Rousseaux, Floriane ; Université de Liège - ULiège > Département de Psychologie > Ergonomie et intervention au travail ; Medical Hypnosis Laboratory, MaisonNeuve-Rosemont Hospital Research Center, University of Montreal, Montreal, Québec, Canada
Carella, Michele ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'anesthésie - réanimation
Gosseries, Olivia ; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group
Bonhomme, Vincent ; Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
ULiège - University of Liège Belgian Foundation Against Cancer Bial Foundation FERB - European Biomedical Research Foundation CHU Liège - Central University Hospital of Liege MSF - Mind Science Foundation FRB - King Baudouin Foundation Leon Fredericq foundation
Funding text :
The study was supported by the University and University Hospital of Liege and its Algology Interdisciplinary Center, the Belgian National Funds for Scientific Research (FRS-FNRS & FRS-FNRS Télévie), the MIS FNRS (F.4521.23), the BIAL Foundation, the Mind Science Foundation, the
fund Generet, the King Baudouin Foundation, the Leon Fredericq foundation, Belgium Foundation Against Cancer [Grants Number: 2017064 and C/2020/1357], the European Foundation of Biomedical Research FERB Onlus and Wallonia as part of a 474 program of the BioWin Health
Cluster framework. OG is a research associate at FRS-FNRS.
Ahmadpour, N., Randall, H., Choksi, H., Gao, A., Vaughan, C., & Poronnik, P., (2019). Virtual reality interventions for acute and chronic pain management. The International Journal of Biochemistry & Cell Biology, 114, 105568. https://doi.org/10.1016/j.biocel.2019.105568
Aivaliotis, V. I., Dlamini, V., Callahan, M., Kelly, C., & Nguyen, L. A. B., (2020). 697 Virtual reality mindfulness therapy vs. Virtual reality distractive therapy in chronic abdominal pain. Adenocarcin Barrett’s Epithelium Gastroenterol, 158(6), S–144. https://doi.org/10.1016/S0016-5085(20)31046-5
Anheyer, D., Haller, H., Barth, J., Lauche, R., Dobos, G., & Cramer, H., (2017). Mindfulness-based stress reduction for treating low back pain: A systematic review and meta-analysis. Annals of Internal Medicine, 166(11), 799–807. https://doi.org/10.7326/M16-1997
Austin, P. D., (2022). The analgesic effects of virtual reality for people with chronic pain: A scoping review. Pain Medicine (United States), 23(1), 105–121. https://doi.org/10.1093/pm/pnab217
Ball, E. F., Nur Shafina Muhammad Sharizan, E., Franklin, G., & Rogozińska, E., (2017). Does mindfulness meditation improve chronic pain? A systematic review. Current Opinion in Obstetrics & Gynecology, 29(6), 359–366. https://doi.org/10.1097/GCO.0000000000000417
Bauer, B. A., Tilburt, J. C., Sood, A., Li, G. X., & Wang, S. H., (2016). Complementary and alternative medicine therapies for chronic pain. Chinese Journal of Integrative Medicine, 22(6), 403–411. https://doi.org/10.1007/s11655-016-2258-y
Bernaerts, S., Bonroy, B., Daems, J., Sels, R., Struyf, D., & Van de Veerdonk, W., (2021). Virtual reality for relaxation in a pediatric hospital setting: An interventional study with a mixed-methods design. Annual Review of CyberTherapy and Telemedicine, 19, 133–135. https://doi.org/10.3389/fdgth.2022.866119
Bicego, A., Delmal, P., Ledoux, D., Faymonville, M.-E., Maertens De Noordhout, B., Cerasoli, A., Cassol, H., Gosseries, O., & Vanhaudenhuyse, A., (2022). Self-hypnosis for phantom limb pain: A multiple-case study. OBM Integrative and Complementary Medicine, 7(3), Article 3. https://doi.org/10.21926/obm.icm.2203040
Bicego, A., Rousseaux, F., Faymonville, M. E., Nyssen, A. S., & Vanhaudenhuyse, A., (2022). Neurophysiology of hypnosis in chronic pain: A review of recent literature. The American Journal of Clinical Hypnosis, 64(1), 62–80. https://doi.org/10.1080/00029157.2020.1869517
Botella, C., Garcia-Palacios, A., Vizcaíno, Y., Herrero, R., Baños, R. M., & Belmonte, M. A., (2013). Virtual reality in the treatment of fibromyalgia: A pilot study. Cyberpsychology, Behavior and Social Networking, 16(3), 215–223. https://doi.org/10.1089/cyber.2012.1572
Breivik, H., Collett, B., Ventafridda, V., Cohen, R., & Gallacher, D., (2006). Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment. European Journal of Pain (London, England), 10(4), 287–333. https://doi.org/10.1016/j.ejpain.2005.06.009
Brown, L., Chen, E. T., & Binder, D. S., (2020). The use of virtual reality for peri-procedural pain and anxiety at an outpatient spine clinic injection visit: An exploratory controlled randomized trial. American Journal of Translational Research, 12(9), 5818–5826. www.ajtr.org
Brungardt, A., Wibben, A., Tompkins, A. F., Shanbhag, P., Coats, H., Lagasse, A. B., Boeldt, D., Youngwerth, J., Kutner, J. S., & Lum, H. D., (2021). Virtual reality-based music therapy in palliative care: A pilot implementation trial. Journal of Palliative Medicine, 24(5), 736–742. https://doi.org/10.1089/jpm.2020.0403
Buche, H., Michel, A., Piccoli, C., & Blanc, N., (2021). Contemplating or acting? Which immersive modes should Be favored in virtual reality during physiotherapy for breast cancer rehabilitation. Frontiers in Psychology, 12, 12. https://doi.org/10.3389/fpsyg.2021.631186
Buckenmaier, C. C.,III, Galloway, K. T., Polomano, R. C., McDuffie, M., Kwon, N., & Gallagher, R. M., (2013). Preliminary validation of the Defense and Veterans Pain Rating Scale (DVPRS) in a military population. Pain Medicine, 14(1), 110–123. https://doi.org/10.1111/j.1526-4637.2012.01516.x
Camargo-Vargas, D., Callejas-Cuervo, M., & Mazzoleni, S., (2021). Brain-computer interfaces systems for upper and lower limb rehabilitation: A systematic review. Sensors (Basel, Switzerland), 21(13), 4312. https://doi.org/10.3390/s21134312
Cleeland, C. S., & Ryan, K. M., (1994). Pain assessment: Global use of the brief pain inventory. Annals of the Academy of Medicine, Singapore, 23(2), 129–138.
Colloca, L., Raghuraman, N., Wang, Y., Akintola, T., Brawn-Cinani, B., Colloca, G. C., Kier, C., Varshney, A., & Murthi, S., (2020). Virtual reality: Physiological and behavioral mechanisms to increase individual pain tolerance limits. Pain, 161(9), 2010–2021. https://doi.org/10.1097/j.pain.0000000000001900
Coulibaly, I., Cardelli, L. S., Duflos, C., Moulis, L., Mandoorah, B., Nicoleau, J., Placide, L., Massin, F., Pasquié, J. L., & Granier, M., (2022). Virtual reality hypnosis in the electrophysiology lab: When human treatments are better than virtual ones. Journal of Clinical Medicine, 11(13), 3913. https://doi.org/10.3390/jcm11133913
Creswell, J. D., (2017). Mindfulness interventions. Annual Review of Psychology, 68(1), 491–516. https://doi.org/10.1146/annurev-psych-042716-051139
Darnall, B. D., Krishnamurthy, P., Tsuei, J., & Minor, J. D., (2020). Self-administered skills-based virtual reality intervention for chronic pain: Randomized controlled pilot study. JMIR Formative Research, 4(7), e17293. https://doi.org/10.2196/17293
Demertzi, A., Soddu, A., Faymonville, M. E., Bahri, M. A., Gosseries, O., Vanhaudenhuyse, A., Phillips, C., Maquet, P., Noirhomme, Q., Luxen, A., & Laureys, S., (2011). Hypnotic modulation of resting state fMRI default mode and extrinsic network connectivity. In Progress in brain research (Vol. 193, pp. 309–322). Elsevier B.V. https://doi.org/10.1016/B978-0-444-53839-0.00020-X
Döllinger, N., Wienrich, C., & Latoschik, M. E., (2021). Challenges and opportunities of immersive technologies for mindfulness meditation: A systematic review. Frontiers in Virtual Reality, 2, 2. https://doi.org/10.3389/frvir.2021.644683
Elkins, G. R., Barabasz, A. F., Council, J. R., & Spiegel, D., (2015). Advancing research and practice: The revised APA division 30 definition of hypnosis. The American Journal of Clinical Hypnosis, 57(4), 378–385. https://doi.org/10.1080/00029157.2015.1011465
Enea, V., Dafinoiu, I., Opriş, D., & David, D., (2014). Effects of hypnotic analgesia and virtual reality on the reduction of experimental pain among high and low hypnotizables. The International Journal of Clinical and Experimental Hypnosis, 62(3), 360–377. https://doi.org/10.1080/00207144.2014.901087
Esumi, R., Yokochi, A., Shimaoka, M., & Kawamoto, E., (2020). Virtual reality as a non-pharmacologic analgesic for fasciotomy wound infections in acute compartment syndrome: A case report. Journal of Medical Case Reports, 14(1). https://doi.org/10.1186/s13256-020-02370-4
Faraj, M. M., Lipanski, N. M., Morales, A., Goldberg, E., Bluth, M. H., Marusak, H. A., & Greenwald, M. K., (2021). A virtual reality meditative intervention modulates pain and the pain neuromatrix in patients with opioid use disorder. Pain Medicine (United States), 22(11), 2739–2753. https://doi.org/10.1093/pm/pnab162
Franch, M., Alarcón, A., & Capafons, A., (2023). Applications of hypnosis as an adjuvant in oncological settings: A systematic review. The International Journal of Clinical and Experimental Hypnosis, 71(1), 1–24. https://doi.org/10.1080/00207144.2022.2160255
Garcia, L., Darnall, B., Krishnamurthy, P., Mackey, I., Sackman, J., Louis, R., Maddox, T., & Birckhead, B., (2021). Self-administered behavioral skills–based at-home virtual reality therapy for chronic low back pain: Protocol for a randomized controlled trial. JMIR Research Protocols, 10(1), e25291. https://doi.org/10.2196/25291
Garcia, L. M., Birckhead, B. J., Krishnamurthy, P., Mackey, I., Sackman, J., Salmasi, V., Louis, R., Maddox, T., & Darnall, B. D., (2022). Three-month follow-up results of a double-blind, randomized placebo-controlled trial of 8-week self-administered at-home behavioral skills-based Virtual Reality (VR) for chronic low back pain. The Journal of Pain, 23(5), 822–840. https://doi.org/10.1016/j.jpain.2021.12.002
Garland, E. L., Brintz, C. E., Hanley, A. W., Roseen, E. J., Atchley, R. M., Gaylord, S. A., Faurot, K. R., Yaffe, J., Fiander, M., & Keefe, F. J., (2020). Mind-body therapies for opioid-treated pain: A systematic review and meta-analysis. JAMA Internal Medicine, 180(1), 91–105. https://doi.org/10.1001/jamainternmed.2019.4917
Garrett, B. M., Tao, G., Taverner, T., Cordingley, E., & Sun, C., (2020). Patients perceptions of virtual reality therapy in the management of chronic cancer pain. Heliyon, 6(5), e03916. https://doi.org/10.1016/j.heliyon.2020.e03916
Gasteratos, K., Papakonstantinou, M., Man, A., Babatsikos, E., Tamalonis, A., & Goverman, J., (2022). Adjunctive nonpharmacologic interventions for the management of burn pain: A systematic review. Plastic and Reconstructive Surgery, 149(5), 985E–994E. https://doi.org/10.1097/PRS.0000000000009059
Gatchel, R. J., Peng, Y. B., Peters, M. L., Fuchs, P. N., & Turk, D. C., (2007). The biopsychosocial approach to chronic pain: Scientific advances and future directions. Psychological Bulletin, 133(4), 581–624. https://doi.org/10.1037/0033-2909.133.4.581
Global Burden of Disease Study 2013 Collaborators. (2015). Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: A systematic analysis for the global burden of disease study 2013. Lancet (London, England), 386(9995), 743–800. https://doi.org/10.1016/S0140-6736(15)60692-4
Goyal, M., Singh, S., Sibinga, E. M. S., Gould, N. F., Rowland-Seymour, A., Sharma, R., Berger, Z., Sleicher, D., Maron, D. D., Shihab, H. M., Ranasinghe, P. D., Linn, S., Saha, S., Bass, E. B., & Haythornthwaite, J. A., (2014). Meditation programs for psychological stress and well-being: A systematic review and meta-analysis. JAMA Internal Medicine, 174(3), 357–368. https://doi.org/10.1001/jamainternmed.2013.13018
Grégoire, C., Faymonville, M.-E., Vanhaudenhuyse, A., Jerusalem, G., Willems, S., & Bragard, I., (2022). Randomized, controlled trial of an intervention combining self-care and self-hypnosis on fatigue, sleep, and emotional distress in posttreatment cancer patients: 1-year follow-up. The International Journal of Clinical and Experimental Hypnosis, 70(2), 136–155. https://doi.org/10.1080/00207144.2022.2049973
Groenveld, T. D., Smits, M. L. M., Knoop, J., Kallewaard, J. W., Staal, J. B., de Vries, M., & van Goor, H., (2023). Effect of a behavioral therapy-based virtual reality application on quality of life in chronic low back pain. The Clinical Journal of Pain, 39(6), 278–285. https://doi.org/10.1097/AJP.0000000000001110
Groninger, H., Stewart, D., Fisher, J. M., Tefera, E., Cowgill, J., & Mete, M., (2021). Virtual reality for pain management in advanced heart failure: A randomized controlled study. Palliative Medicine, 35(10), 2008–2016. https://doi.org/10.1177/02692163211041273
Gullo, G., Rotzinger, D. C., Colin, A., Frossard, P., Gudmundsson, L., Jouannic, A.-M., & Qanadli, S. D., (2023). Virtually augmented self-hypnosis in peripheral vascular intervention: A randomized controlled trial. Cardiovascular and interventional radiology, 46(6), 786–793. https://doi.org/10.1007/s00270-023-03394-1
Gupta, A., Scott, K., & Dukewich, M., (2018). Innovative technology using virtual reality in the treatment of pain: Does it reduce pain via distraction, or is there more to it?Pain Medicine, 19(1), 151–159. https://doi.org/10.1093/pm/pnx109
Haefeli, M., & Elfering, A., (2006). Pain assessment. European Spine Journal, 15(Suppl 1), S17–S24. https://doi.org/10.1007/s00586-005-1044-x
Haisley, K. R., Straw, O. J., Müller, D. T., Antiporda, M. A., Zihni, A. M., Reavis, K. M., Bradley, D. D., & Dunst, C. M., (2020). Feasibility of implementing a virtual reality program as an adjuvant tool for peri-operative pain control; results of a randomized controlled trial in minimally invasive foregut surgery. Complementary Therapies in Medicine, 49, 49. https://doi.org/10.1016/j.ctim.2020.102356
Hargett, J. L., McElwain, S. D., McNair, M. E., Palokas, M. J., Martin, B. S., & Adcock, D. L., (2022). Virtual reality based guided meditation for patients with opioid tolerance and opioid use disorders. Pain Management Nursing, 23(3), 259–264. https://doi.org/10.1016/j.pmn.2022.02.005
Hartrick, C. T., Kovan, J. P., & Shapiro, S., (2003). The numeric rating scale for clinical pain measurement: A ratio measure?Pain Practice, 3(4), 310–316. https://doi.org/10.1111/j.1530-7085.2003.03034.x
Hilton, L., Hempel, S., Ewing, B. A., Apaydin, E., Xenakis, L., Newberry, S., Colaiaco, B., Maher, A. R., Shanman, R. M., Sorbero, M. E., & Maglione, M. A., (2017). Mindfulness meditation for chronic pain: Systematic review and meta-analysis. Annals of Behavioral Medicine, 51(2), 199–213. https://doi.org/10.1007/s12160-016-9844-2
Hoffman, H. G., Seibel, E. J., Richards, T. L., Furness, T. A., Patterson, D. R., & Sharar, S. R., (2006). Virtual reality helmet display quality influences the magnitude of virtual reality analgesia. The Journal of Pain, 7(11), 843–850. https://doi.org/10.1016/j.jpain.2006.04.006
Honzel, E., Murthi, S., Brawn-Cinani, B., Colloca, G., Kier, C., Varshney, A., & Colloca, L., (2019). Virtual reality, music, and pain: Developing the premise for an interdisciplinary approach to pain management. Pain, 160(9), 1909–1919. https://doi.org/10.1097/j.pain.0000000000001539
Huang, Q., Lin, J., Han, R., Peng, C., & Huang, A., (2022). Using virtual reality exposure therapy in pain management: A systematic review and meta-analysis of randomized controlled trials. Value in Health: The Journal of the International Society for Pharmacoeconomics and Outcomes Research, 25(2), 288–301. https://doi.org/10.1016/j.jval.2021.04.1285
Indovina, P., Barone, D., Gallo, L., Chirico, A., De Pietro, G., & Giordano, A., (2018). Virtual reality as a distraction intervention to relieve pain and distress during medical procedures. The Clinical Journal of Pain, 34(9), 858–877. https://doi.org/10.1097/AJP.0000000000000599
Ioannou, A., Papastavrou, E., Avraamides, M. N., & Charalambous, A., (2020). Virtual reality and symptoms management of anxiety, depression, fatigue, and pain: A systematic review. SAGE Open Nursing, 6, 237796082093616. https://doi.org/10.1177/2377960820936163
Jensen, M. P., Turner, J. A., Romano, J. M., & Strom, S. E., (1995). The chronic pain coping inventory: Development and preliminary validation. Pain, 60(2), 203–216. https://doi.org/10.1016/0304-3959(94)00118-X
Julius, D., & Basbaum, A. I., (2001). Molecular mechanisms of nociception. Nature, 413(6852), 203–210. https://doi.org/10.1038/35093019
Kabat-Zinn, J., (2003). Mindfulness-based interventions in context: Past, present, and future. Clinical Psychology Science & Practice, 10(2), 144–156. https://doi.org/10.1093/clipsy/bpg016
Kavak Akelma, F., Altınsoy, S., Arslan, M. T., & Ergil, J., (2020). Effect of favorite music on postoperative anxiety and pain. Anaesthesist, 69(3), 198–204. https://doi.org/10.1007/s00101-020-00731-8
Keefe, F. J., Huling, D. A., Coggins, M. J., Keefe, D. F., Zachary Rosenthal, M., Herr, N. R., & Hoffman, H. G., (2012). Virtual reality for persistent pain: A new direction for behavioral pain management. Pain, 153(11), 2163–2166. https://doi.org/10.1016/j.pain.2012.05.030
Kelleher, S. A., Fisher, H. M., Winger, J. G., Miller, S. N., Amaden, G. H., Somers, T. J., Colloca, L., Uronis, H. E., & Keefe, F. J., (2022). Virtual reality for improving pain and pain-related symptoms in patients with advanced stage colorectal cancer: A pilot trial to test feasibility and acceptability. Palliative & Supportive Care, 20(4), 471–481. https://doi.org/10.1017/S1478951521002017
Kendrick, C., Sliwinski, J., Yu, Y., Johnson, A., Fisher, W., Kekecs, Z., & Elkins, G., (2016). Hypnosis for Acute Procedural Pain: A Critical Review. The International Journal of Clinical and Experimental Hypnosis, 64(1), 75–115. https://doi.org/10.1080/00207144.2015.1099405
Khusid, M. A., & Vythilingam, M., (2016). The emerging role of mindfulness meditation as effective self-management strategy, part 2: Clinical implications for chronic pain, substance misuse, and insomnia. Military Medicine, 181(9), 969–975. https://doi.org/10.7205/MILMED-D-14-00678
Konstantatos, A. H., Angliss, M., Costello, V., Cleland, H., & Stafrace, S., (2009). Predicting the effectiveness of virtual reality relaxation on pain and anxiety when added to PCA morphine in patients having burns dressings changes. Burns, 35(4), 491–499. https://doi.org/10.1016/j.burns.2008.08.017
Kwekkeboom, K. L., Cherwin, C. H., Lee, J. W., & Wanta, B., (2010). Mind-body treatments for the pain-fatigue-sleep disturbance symptom cluster in persons with cancer. Journal of Pain and Symptom Management, 39(1), 126–138. https://doi.org/10.1016/j.jpainsymman.2009.05.022
Langlois, P., Perrochon, A., David, R., Rainville, P., Wood, C., Vanhaudenhuyse, A., Pageaux, B., Ounajim, A., Lavallière, M., Debarnot, U., Luque-Moreno, C., Roulaud, M., Simoneau, M., Goudman, L., Moens, M., Rigoard, P., & Billot, M., (2022). Hypnosis to manage musculoskeletal and neuropathic chronic pain: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews, 135, 104591. https://doi.org/10.1016/j.neubiorev.2022.104591
Ledowski, T., Tiong, W. S., Lee, C., Wong, B., Fiori, T., & Parker, N., (2013). Analgesia nociception index: Evaluation as a new parameter for acute postoperative pain. BJA: British Journal of Anaesthesia, 111(4), 627–629. https://doi.org/10.1093/bja/aet111
Lee, C., Crawford, C., & Hickey, A., (2014). Mind-body therapies for the self-management of chronic pain symptoms. https://academic.oup.com/painmedicine/article/15/S1/S21/1823803
Li, A., Montaño, Z., Chen, V. J., & Gold, J. I., (2011). Virtual reality and pain management: Current trends and future directions. Pain Management, 1(2), 147–157. https://doi.org/10.2217/pmt.10.15
Liu, K., Madrigal, E., Chung, J. S., Parekh, M., Kalahar, C. S., Nguyen, D., Timmerman, M., & Harris, O. A., (2023). Preliminary study of virtual-reality-guided meditation for veterans with stress and chronic pain. Alternative Therapies in Health and Medicine, 29(6), 42–49.
Louw, A., Louw, C., & Tim, F., (2019). Case report: Pain neuroscience education using virtual reality. Journal of the Physiotherapy Pain Association, 46, 4–7.
Lutz, A., Slagter, H. A., Dunne, J. D., & Davidson, R. J., (2008). Attention regulation and monitoring in meditation. Trends in Cognitive Sciences, 12(4), 163–169. https://doi.org/10.1016/j.tics.2008.01.005
Madden, K., Middleton, P., Cyna, A. M., Matthewson, M., & Jones, L., (2016, 5). Hypnosis for pain management during labour and childbirth. Cochrane Database of Systematic Reviews, 2016(5). https://doi.org/10.1002/14651858.CD009356.pub3
Maindet, C., Burnod, A., Minello, C., George, B., Allano, G., & Lemaire, A., (2019). Strategies of complementary and integrative therapies in cancer-related pain—attaining exhaustive cancer pain management. Supportive Care in Cancer, 27(8), 3119–3132. https://doi.org/10.1007/s00520-019-04829-7
Majeed, M. H., Ali, A. A., & Sudak, D. M., (2018). Mindfulness-based interventions for chronic pain: Evidence and applications. Asian Journal of Psychiatry, 32, 79–83. https://doi.org/10.1016/j.ajp.2017.11.025
Mallari, B., Spaeth, E. K., Goh, H., & Boyd, B. S., (2019). Virtual reality as an analgesic for acute and chronic pain in adults: A systematic review and meta-analysis. Journal of Pain Research, 12, 2053–2085. https://doi.org/10.2147/JPR.S200498
McCaul, K. D., & Malott, J. M., (1984). Distraction and coping with pain. Psychological Bulletin, 95(3), 516–533. https://doi.org/10.1037/0033-2909.95.3.516
McClintock, A. S., McCarrick, S. M., Garland, E. L., Zeidan, F., & Zgierska, A. E., (2019). Brief mindfulness-based interventions for acute and chronic pain: A systematic review. Journal of Alternative and Complementary Medicine (New York, NY), 25(3), 265–278. https://doi.org/10.1089/acm.2018.0351
McCune, M., Tufano, S., Gill, M., Oelkers, K., Segaline, N., Foote, J., Aguirre, A., & Mahnert, N. D., (2023). Virtual reality for the treatment of postoperative pain after laparoscopic hysterectomy for benign indications: A randomized controlled trial. European Journal of Obstetrics & Gynecology and Reproductive Biology, 289, 19–22. https://doi.org/10.1016/j.ejogrb.2023.08.012
McGrath, P. A., Seifert, C. E., Speechley, K. N., Booth, J. C., Stitt, L., & Gibson, M. C., (1996). A new analogue scale for assessing children’s pain: An initial validation study. Pain, 64(3), 435–443. https://doi.org/10.1016/0304-3959(95)00171-9
Melzack, R., (2001). Pain and the neuromatrix in the brain. Journal of Dental Education, 65(12), 1378–1382. https://doi.org/10.1002/j.0022-0337.2001.65.12.tb03497.x
Menekli, T., Yaprak, B., & Doğan, R., (2022). The effect of virtual reality distraction intervention on pain, anxiety, and vital signs of oncology patients undergoing port catheter implantation: A randomized controlled study. Pain Management Nursing, 23(5), 585–590. https://doi.org/10.1016/j.pmn.2022.03.004
Merliot-Gailhoustet, L., Raimbert, C., Garnier, O., Carr, J., De Jong, A., Molinari, N., Jaber, S., & Chanques, G., (2022). Discomfort improvement for critically ill patients using electronic relaxation devices: Results of the cross-over randomized controlled trial E-CHOISIR (Electronic-CHOIce of a system for intensive care relaxation). Critical Care, 26(1). https://doi.org/10.1186/s13054-022-04136-4
Merskey, H., (1994). Logic, truth and language in concepts of pain. Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care & Rehabilitation, 3(Suppl 1), S69–76. https://doi.org/10.1007/BF00433379
Michaelides, A., & Zis, P., (2019). Depression, anxiety and acute pain: Links and management challenges. Postgraduate Medicine, 131(7), 438–444. https://doi.org/10.1080/00325481.2019.1663705
Milgram, P., & Kishino, F., (1994). A taxonomy of mixed reality visual displays. IEICE Transactions on Information and Systems. https://www.semanticscholar.org/paper/A-Taxonomy-of-Mixed-Reality-Visual-Displays-Milgram-Kishino/f78a31be8874eda176a5244c645289be9f1d4317
Morone, N. E., Lynch, C. S., Greco, C. M., Tindle, H. A., & Weiner, D. K., (2008). « I felt like a new person. » the effects of mindfulness meditation on older adults with chronic pain: Qualitative narrative analysis of diary entries. The Journal of Pain, 9(9), 841–848. https://doi.org/10.1016/j.jpain.2008.04.003
Olbrecht, V. A., O’conor, K. T., Williams, S. E., Boehmer, C. O., Marchant, G. W., Glynn Bs, S. M., Geisler, K. J., Ding, L., Yang, G., & King, C. D., (2020). Guided relaxation-based virtual reality transiently reduces acute postoperative pain and anxiety in a pediatric population. BMJ Open, 10(12), e040295. https://doi.org/10.1136/bmjopen-2020-040295
Oneal, B. J., Patterson, D. R., Soltani, M., Teeley, A., & Jensen, M. P., (2008). Virtual reality hypnosis in the treatment of chronic neuropathic pain: A case report. The International Journal of Clinical and Experimental Hypnosis, 56(4), 451–462. https://doi.org/10.1080/00207140802255534
Patterson, D. R., Hoffman, H. G., Chambers, G., Bennetts, D., Hunner, H. H., Wiechman, S. A., Garcia-Palacios, A., & Jensen, M. P., (2021). Hypnotic enhancement of virtual reality distraction analgesia during thermal pain: A randomized trial. The International Journal of Clinical and Experimental Hypnosis, 69(2), 225–245. https://doi.org/10.1080/00207144.2021.1882259
Patterson, D. R., Jensen, M. P., Wiechman, S. A., & Sharar, S. R., (2010). Virtual reality hypnosis for pain associated with recovery from physical trauma. The International Journal of Clinical and Experimental Hypnosis, 58(3), 288–300. https://doi.org/10.1080/00207141003760595
Patterson, D. R., Tininenko, J. R., Schmidt, A. E., & Sharar, S. R., (2004). Virtual reality hypnosis: A case report. The International Journal of Clinical and Experimental Hypnosis, 52(1), 27–38. https://doi.org/10.1076/iceh.52.1.27.23925
Patterson, D. R., Wiechman, S. A., Jensen, M., & Sharar, S. R., (2006). Hypnosis delivered through immersive virtual reality for burn pain: A clinical case series. The International Journal of Clinical and Experimental Hypnosis, 54(2), 130–142. https://doi.org/10.1080/00207140500528182
Payne, O., Smith, V., Rolnik, D. L., Davies-Tuck, M., Warty, R., Seo, D., Wetherell, L., Murday, H. K., Nair, A., Kaur, R., & Vollenhoven, B., (2022). Virtual reality and its use in post-operative pain following laparoscopy: A feasibility study. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-17183-2
Pei, J.-H., Ma, T., Nan, R.-L., Chen, H.-X., Zhang, Y.-B., Gou, L., & Dou, X.-M., (2021). Mindfulness-based cognitive therapy for treating chronic pain a systematic review and meta-analysis. Psychology, Health and Medicine, 26(3), 333–346. https://doi.org/10.1080/13548506.2020.1849746
Perez-Marcos, D., (2018). Virtual reality experiences, embodiment, videogames and their dimensions in neurorehabilitation. Journal of Neuroengineering and Rehabilitation, 15(1), 113. https://doi.org/10.1186/s12984-018-0461-0
Pourmand, A., Davis, S., Marchak, A., Whiteside, T., & Sikka, N., (2018). Virtual reality as a clinical tool for pain management. Current Pain and Headache Reports, 22(8), 53. https://doi.org/10.1007/s11916-018-0708-2
Raja, S. N., Carr, D. B., Cohen, M., Finnerup, N. B., Flor, H., Gibson, S., Keefe, F. J., Mogil, J. S., Ringkamp, M., Sluka, K. A., Song, X. J., Stevens, B., Sullivan, M. D., Tutelman, P. R., Ushida, T., & Vader, K., (2020). The revised international association for the study of pain definition of pain: Concepts, challenges, and compromises. Pain, 161(9), 1976–1982. https://doi.org/10.1097/j.pain.0000000000001939
Rice, V. J., Liu, B., Allison, S. C., & Schroeder, P. J., (2019). Mindfulness training offered In-person and in a virtual world—weekly self-reports of stress, energy, pain, and sleepiness among US military active duty and veteran personnel. Mindfulness, 10(9), 1815–1827. https://doi.org/10.1007/s12671-019-01129-3
Rousseaux, F., Dardenne, N., Massion, P. B., Ledoux, D., Bicego, A., Donneau, A.-F., Faymonville, M.-E., Nyssen, A.-S., & Vanhaudenhuyse, A., (2022). Virtual reality and hypnosis for anxiety and pain management in intensive care units: A prospective randomised trial among cardiac surgery patients. European Journal of Anaesthesiology | EJA, 39(1), 58. https://doi.org/10.1097/EJA.0000000000001633
Rousseaux, F., Faymonville, M. E., Nyssen, A. S., Dardenne, N., Ledoux, D., Massion, P. B., & Vanhaudenhuyse, A., (2020). Can hypnosis and virtual reality reduce anxiety, pain and fatigue among patients who undergo cardiac surgery: A randomised controlled trial. Trials, 21(1). https://doi.org/10.1186/s13063-020-4222-6
Rousseaux, F., Panda, R., Toussaint, C., Bicego, A., Niimi, M., Faymonville, M. E., Nyssen, A. S., Laureys, S., Gosseries, O., & Vanhaudenhuyse, A., (2022). Virtual reality hypnosis in the management of pain: Self-reported and neurophysiological measures in healthy subjects. European Journal of Pain. United Kingdom. https://doi.org/10.1002/ejp.2045
Salamon, E., Esch, T., & Stefano, G. B., (2006). Pain and relaxation (review). International Journal of Molecular Medicine, 18(3), 465–470. https://doi.org/10.3892/ijmm.18.3.465
Santiváñez-Acosta, R., Tapia-López, E. D. L. N., & Santero, M., (2020). Music therapy in pain and anxiety management during labor: A systematic review and meta-analysis. Medicina (Lithuania), 56(10), 1–11. https://doi.org/10.3390/medicina56100526
Sarkar, T. D., Edwards, R. R., & Baker, N., (2022). The feasibility and effectiveness of virtual reality meditation on reducing chronic pain for older adults with knee osteoarthritis. Pain Practice, 22(7), 631–641. https://doi.org/10.1111/papr.13144
Scates, D., Dickinson, J. I., Sullivan, K., Cline, H., & Balaraman, R., (2020). Using nature-inspired virtual reality as a distraction to reduce stress and pain among cancer patients. Environment & Behavior, 52(8), 895–918. https://doi.org/10.1177/0013916520916259
Sharma, H., (2015). Meditation: Process and effects. AYU (An International Quarterly Journal of Research in Ayurveda), 36(3), 233–237. https://doi.org/10.4103/0974-8520.182756
Sine, H., Achbani, A., & Filali, K., (2022). The effect of hypnosis on the intensity of pain and anxiety in cancer patients: A systematic review of controlled experimental trials. Cancer Investigation, 40(3), 235–253. https://doi.org/10.1080/07357907.2021.1998520
Skelly, A. C., Chou, R., Dettori, J. R., Turner, J. A., Friedly, J. L., Rundell, S. D., Fu, R., Brodt, E. D., Wasson, N., Kantner, S., & Ferguson, A. J. R., (2020). Noninvasive nonpharmacological treatment for chronic pain: A systematic review update. Agency for Healthcare Research and Quality (US). http://www.ncbi.nlm.nih.gov/books/NBK556229/
Smith, C. A., Levett, K. M., Collins, C. T., Armour, M., Dahlen, H. G., & Suganuma, M., (2018). Relaxation techniques for pain management in labour. Cochrane Database of Systematic Reviews, 3(3), CD009514. https://doi.org/10.1002/14651858.CD009514.pub2
Soltani, M., Teeley, A. M., Wiechman, S. A., Jensen, M. P., Sharar, S. R., & Patterson, D. R., (2011). Virtual reality hypnosis for pain control in a patient with gluteal hidradenitis: A case report 1. Contemporary Hypnosis & Integrative Therapy, 28(2), 142
Spiegel, D., (1991). Neurophysiological correlates of hypnosis and dissociation. Journal of Neuropsychiatry and Clinical Neurosciences, 3(4), 440–445. https://doi.org/10.1176/jnp.3.4.440
Sunil Kumar Reddy, K., Naidu, M. U. R., Rani, P. U., Ramesh, T., Rao, K., Sunil, M. K., & Reddy, K., (2012). Human experimental pain models: A review of standardized methods in drug development. Journal of Research in Medical Sciences, 587. www.journals.mui.ac.ir/jrms
Tan, L., Fang, P., Cui, J., Yu, H., & Yu, L., (2022). Effects of progressive muscle relaxation on health-related outcomes in cancer patients: A systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Clinical Practice, 49, 101676. https://doi.org/10.1016/j.ctcp.2022.101676
Teeley, A. M., Soltani, M., Wiechman, S. A., Jensen, M. P., Sharar, S. R., & Patterson, D. R., (2012). Virtual reality hypnosis pain control in the treatment of multiple fractures: A case series 1. The American Journal of Clinical Hypnosis, 54(3), 184–194. https://doi.org/10.1080/00029157.2011.619593
Terzulli, C., Melchior, M., Goffin, L., Faisan, S., Gianesini, C., Graff, D., Dufour, A., Laroche, E., Chauvin, C., & Poisbeau, P., (2022). Effect of virtual reality hypnosis on pain threshold and neurophysiological and autonomic biomarkers in healthy volunteers: Prospective randomized crossover study. Journal of Medical Internet Research, 24(7), e33255. https://doi.org/10.2196/33255
Tricco, A. C., Lillie, E., Zarin, W., O’Brien, K. K., Colquhoun, H., Levac, D., Moher, D., Peters, M. D. J., Horsley, T., Weeks, L., Hempel, S., Akl, E. A., Chang, C., McGowan, J., Stewart, L., Hartling, L., Aldcroft, A., Wilson, M. G., Garritty, C., … Straus, S. E., (2018). PRISMA extension for scoping reviews (PRISMA-ScR): Checklist and explanation. Annals of Internal Medicine, 169(7), 467–473. https://doi.org/10.7326/M18-0850
van den Berg, S., Hoogeveen, M. O., van Winden, T. M. S., Chegary, M., Genco, M. S., & Jonkman, N. H., (2023). Virtual reality hypnosis for needle-related procedural pain and fear management in children: A non-inferiority randomized trial. European Journal of Pediatrics, 182(10), 4421–4430. https://doi.org/10.1007/s00431-023-05116-8
Vanhaudenhuyse, A., Gillet, A., Malaise, N., Salamun, I., Grosdent, S., Maquet, D., Nyssen, A. S., & Faymonville, M. E., (2018). Psychological interventions influence patients’ attitudes and beliefs about their chronic pain. Journal of Traditional and Complementary Medicine, 8(2), 296–302. https://doi.org/10.1016/j.jtcme.2016.09.001
Vanhaudenhuyse, A., Nyssen, A.-S., & Faymonville, M.-E., (2020). Recent insight on how the neuroscientific approach helps clinicians. OBM Integrative and Complementary Medicine, 5(2), Article 2. https://doi.org/10.21926/obm.icm.2002028
Vekhter, D., Robbins, M. S., Minen, M., & Buse, D. C., (2020). Efficacy and feasibility of behavioral treatments for migraine, headache, and pain in the acute care setting. Current Pain and Headache Reports, 24(10). https://doi.org/10.1007/s11916-020-00899-z
Venuturupalli, R. S., Chu, T., Vicari, M., Kumar, A., Fortune, N., & Spielberg, B., (2019). Virtual reality–based biofeedback and guided meditation in rheumatology: A pilot study. ACR Open Rheumatology, 1(10), 667–675. https://doi.org/10.1002/acr2.11092
Weech, S., Kenny, S., & Barnett-Cowan, M., (2019). Presence and cybersickness in virtual reality are negatively related: A review. Frontiers in Psychology, 10(FEB). https://doi.org/10.3389/fpsyg.2019.00158
Weitzenhoffer, A. M., (2002). Scales, scales and more scales. The American Journal of Clinical Hypnosis, 44(3–4), 209–219. https://doi.org/10.1080/00029157.2002.10403481
Wiechman, S. A., Jensen, M. P., Sharar, S. R., Barber, J. K., Soltani, M., & Patterson, D. R., (2022). The impact of virtual reality hypnosis on pain and anxiety caused by trauma: Lessons learned from a clinical trial. The International Journal of Clinical and Experimental Hypnosis, 70(2), 156–173. https://doi.org/10.1080/00207144.2022.2052296
Wong, M. S., Gregory, K. D., Spiegel, B. M. R., & Khalil, C., (2022). Patient perceptions of virtual reality for pain relief in labor: A qualitative study. Frontiers in Pain Research, 3. https://doi.org/10.3389/fpain.2022.1063751
Wren, A. A., Neiman, N., Caruso, T. J., Rodriguez, S., Taylor, K., Madill, M., Rives, H., & Nguyen, L., (2021). Mindfulness-based virtual reality intervention for children and young adults with inflammatory bowel disease: A pilot feasibility and acceptability study. Children, 8(5), 368. https://doi.org/10.3390/children8050368
Zeidan, F., & Vago, D. R., (2016). Mindfulness meditation–based pain relief: A mechanistic account. Annals of the New York Academy of Sciences, 1373(1), 114–127. https://doi.org/10.1111/nyas.13153
Zhang, B., Li, D., Liu, Y., Wang, J., & Xiao, Q., (2021). Virtual reality for limb motor function, balance, gait, cognition and daily function of stroke patients: A systematic review and meta-analysis. Journal of Advanced Nursing, 77(8), 3255–3273. https://doi.org/10.1111/jan.14800
