Article (Scientific journals)
Childhood Bacterial Meningitis Surveillance in Southern Vietnam: Trends and Vaccination Implications From 2012 to 2021
Truong, Hieu Cong; Van Phan, Thanh; Nguyen, Hung Thanh et al.
2023In Open Forum Infectious Diseases, 10 (7)
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Keywords :
childhood bacterial meningitis; epidemiology; surveillance; vaccination implications; Vietnam; Oncology; Infectious Diseases
Abstract :
[en] Background: This retrospective hospital-based surveillance aimed to assess the epidemiology, causative pathogens trend, and serotypes distribution of pneumococcal meningitis among children aged under 5 years with bacterial meningitis in Southern Vietnam after the introduction of pentavalent vaccine in the Expanded Program on Immunization (EPI). Methods: From 2012 to 2021, cerebrospinal fluid samples were collected from children aged under 5 years with suspected bacterial meningitis at Children's Hospitals 1 and 2 in Ho Chi Minh City. Probable bacterial meningitis (PBM) cases were identified using biochemistry and cytology. Real-time polymerase chain reaction was used to confirm cases of confirmed bacterial meningitis (CBM) caused by Streptococcus pneumoniae, Haemophilus influenzae, or Neisseria meningitidis. Streptococcus pneumoniae serotyping was performed. Results: Of the 2560 PBM cases, 158 (6.2%) were laboratory-confirmed. The CBM proportion decreased during the 10-year study and was associated with age, seasonality, and permanent residence. Streptococcus pneumoniae was the most common pathogen causing bacterial meningitis (86.1%), followed by H influenzae (7.6%) and N meningitidis (6.3%). The case-fatality rate was 8.2% (95% confidence interval, 4.2%-12.2%). Pneumococcal serotypes 6A/B, 19F, 14, and 23F were the most prevalent, and the proportion of pneumococcal meningitis cases caused by the 10-valent pneumococcal conjugate vaccine (PCV) serotypes decreased from 96.2% to 57.1% during the PCV eras. Conclusions: Streptococcus pneumoniae is the most frequent causative agent of bacterial meningitis in children aged under 5 years in Southern Vietnam over the last decade. Policymakers may need to consider introducing PCVs into the EPI to effectively prevent and control bacterial meningitis.
Disciplines :
Public health, health care sciences & services
Author, co-author :
Truong, Hieu Cong ;  Pasteur Institute in Ho Chi Minh City, Ho Chi Minh City, Viet Nam ; Institute of Health and Society, UniversitCrossed D Sign© Catholique de Louvain, Brussels, Belgium
Van Phan, Thanh;  Pasteur Institute in Ho Chi Minh City, Ho Chi Minh City, Viet Nam
Nguyen, Hung Thanh;  Children's Hospital 1, Ho Chi Minh City, Viet Nam
Truong, Khanh Huu;  Children's Hospital 1, Ho Chi Minh City, Viet Nam
Do, Viet Chau;  Children's Hospital 2, Ho Chi Minh City, Viet Nam
Pham, Nguyet Nguyen My;  Children's Hospital 2, Ho Chi Minh City, Viet Nam
Ho, Thang Vinh;  Pasteur Institute in Ho Chi Minh City, Ho Chi Minh City, Viet Nam
Phan, Tram Thi Quynh;  Pasteur Institute in Ho Chi Minh City, Ho Chi Minh City, Viet Nam
Hoang, Thang Anh;  Pasteur Institute in Ho Chi Minh City, Ho Chi Minh City, Viet Nam
Soetewey, Antoine  ;  Université de Liège - ULiège > HEC Liège Research > HEC Liège Research: Business Analytics & Supply Chain Mgmt ; Institute of Statistics,Biostatistics and Actuarial Sciences, UniversitCrossed D Sign© Catholique de Louvain, Louvain-la-Neuve, Belgium
Ho, Thuy Nguyen Loc;  Pasteur Institute in Ho Chi Minh City, Ho Chi Minh City, Viet Nam
Pham, Quang Duy;  Pasteur Institute in Ho Chi Minh City, Ho Chi Minh City, Viet Nam
Luong, Quang Chan;  Pasteur Institute in Ho Chi Minh City, Ho Chi Minh City, Viet Nam
Vo, Dai Thi Trang;  Pasteur Institute in Ho Chi Minh City, Ho Chi Minh City, Viet Nam
Nguyen, Thuong Vu;  Pasteur Institute in Ho Chi Minh City, Ho Chi Minh City, Viet Nam
Speybroeck, Niko;  Institute of Health and Society, UniversitCrossed D Sign© Catholique de Louvain, Brussels, Belgium
More authors (6 more) Less
Language :
English
Title :
Childhood Bacterial Meningitis Surveillance in Southern Vietnam: Trends and Vaccination Implications From 2012 to 2021
Publication date :
July 2023
Journal title :
Open Forum Infectious Diseases
eISSN :
2328-8957
Publisher :
Oxford University Press
Volume :
10
Issue :
7
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
WHO - World Health Organization
UC Louvain
Funding text :
The probable bacterial meningitis sentinel surveillance was supported by a grant from the WHO to the Pasteur Institute in Ho Chi Minh City. This work was supported through funding by the Université Catholique de Louvain Developing countries cooperation - PhD Scholarships.
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