Reference : Viral glycoproteins in herpesviridae granulomas
Scientific journals : Article
Human health sciences : Immunology & infectious disease
Human health sciences : Dermatology
Viral glycoproteins in herpesviridae granulomas
Nikkels, Arjen mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie > >]
Debrus, S. [> > > >]
Delvenne, Philippe mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques > >]
Sadzot-Delvaux, Catherine mailto [Université de Liège - ULiège > Département des sciences de la vie > Virologie et immunologie > >]
Piette, Jacques mailto [Université de Liège - ULiège > Département des sciences de la vie > Virologie - Immunologie >]
Rentier, Bernard mailto [Université de Liège - ULiège > Département de Microbiologie > Virologie fondamentale et Immunologie > >]
Pierard, Gérald mailto [Université de Liège - ULiège > Département des sciences cliniques > Dermatopathologie >]
American Journal of Dermatopathology
Raven Press Publishers
Yes (verified by ORBi)
[en] Varicella zoster virus ; Herpes simplex virus ; Granuloma ; Immunohistochemistry ; In situ hybridization
[en] Granulomatous reactions after varicella zoster virus (VZV) and herpes simplex virus (HSV) infections are rare, and their pathogenesis remains unclear. We studied by immunohistochemistry and in situ hybridization early granulomatous reactions after VZV and HSV infections. In the five cases studied, the VZV glycoproteins gp I and gp II were present in cells abutted to altered vessels, but the corresponding genome sequences were disclosed in similar locations in only one of these cases. In an immunocompromised patient with diffuse HSV eruption, HSV I antigens were present in cells of the reticular dermis, while viral nucleic acids were not evident. Immunophenotyping of the granulomas showed strong Mac 387 and CD68 positive labelings of macrophages/monocytes, without any involvement of Factor XIIIa-positive cells. These findings suggest that the major viral envelope glycoproteins, rather than complete viral particles could trigger granuloma formation following HSV and VZV skin infections.
Researchers ; Professionals

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