Keywords :
Sodium-Glucose Transporter 2 Inhibitors; Hypoglycemic Agents; Humans; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use/adverse effects; Diabetes Mellitus, Type 2/drug therapy/complications; Hypoglycemic Agents/therapeutic use/adverse effects; Cardiovascular Diseases/prevention & control; Heart Failure/drug therapy; Evidence-Based Medicine
Abstract :
[en] SGLT2 inhibitors (gliflozins) have proven their efficacy in reducing complications due to atherosclerotic cardiovascular disease, heart failure and chronic kidney disease both in placebo-controlled clinical trials and in real-life studies versus other glucose-lowering agents (except GLP-1 analogues) in patients with type 2 diabetes. Hence, observational studies demonstrate that they are poorly used in -clinical practice, including in patients at high cardiorenal risk. -Reasons are multiple and involve physicians, patients and health care system with restricted criteria for prescription and reimbursement in many countries. Bridging the gap between scientific proves from evidence-based medicine and clinical practice represents a major health-care issue.
Disciplines :
Pharmacy, pharmacology & toxicology
Cardiovascular & respiratory systems
Endocrinology, metabolism & nutrition
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