[en] Ring-closing enyne metathesis (RCEYM) is a powerful synthetic strategy to build complex molecular architectures, including carbocycles and heterocycles, which are crucial for natural product synthesis. In this review, we delve into the mechanistic nuances of RCEYM, with a focus on the role of the well-defined Grubbs and Hoveyda-Grubbs ruthenium-alkylidene catalysts. Notably, integrating computational and experimental findings, we highlight how the sophisticated interplay of catalytic and substrate variables orchestrate the RCEYM process thus dictating reaction pathways and selectivity.
Disciplines :
Chemistry
Author, co-author :
Mitan, Carmen-Irena; Institute of Organic and Supramolecular Chemistry “C. D. Nenitescu”, Romanian Academy, Bucharest, Romania
Filip, Petru; Institute of Organic and Supramolecular Chemistry “C. D. Nenitescu”, Romanian Academy, Bucharest, Romania
Delaude, Lionel ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie organométallique et catalyse homogène
Dragutan, Valerian; Institute of Organic and Supramolecular Chemistry “C. D. Nenitescu”, Romanian Academy, Bucharest, Romania
Language :
English
Title :
Mechanistic aspects of the ring-closing enyne metathesis catalyzed by ruthenium-alkylidene complexes
Financial support from the Romanian Academy and Wallonie-Bruxelles International is gratefully acknowledged. C.-I. M. would like to thank the \u201CCarol I\u201D Central University Library of Bucharest and the University of Illinois at Chicago for providing access to the literature cited in this review.
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