[en] Frequent occurrence of wound infection caused by multiple-resistant bacteria (MRB) has posed a serious challenge to the current healthcare system relying on antibiotics. The development of novel antimicrobial materials with high safety and efficacy to heal wound infection is of great importance in combating this crisis. Herein, we prepared a promising antibacterial hydrogel by cross-linking ferrous ions (Fe2+) with the deprotonated carboxyl anion in sodium alginate (Na-ALG) to cure wound infections caused by methicillin-resistant Staphylococcus aureus (MRSA). Interestingly, ferrous-modified Na-ALG (Fe-ALG) hydrogel demonstrated better properties compared to the traditional Na-ALG-based hydrogels, including injectability, self-healing, appropriate fluidity, high-water retention, potent MRSA-killing efficacy, and excellent biocompatibility. Importantly, the addition of Fe2+ enhances the antibacterial efficacy of the Na-ALG hydrogel, enabling it to effectively eliminate MRSA and accelerate the healing of antibiotic-resistant bacterial-infected wounds in a remarkably short period (10 days). This modification not only facilitates wound closure and fur generation, but also mitigates systemic inflammation, thereby effectively impeding the spread of MRSA to the lungs. Taken together, Fe-ALG hydrogel is a promising therapeutic material for treating wound infections by Staphylococcus aureus, especially by antibiotic-resistant strains like MRSA.
Disciplines :
Chemistry
Author, co-author :
Wang, Zhen; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, China ; Laboratory of Biomass and Green Technologies, University of Liege, Belgium
An, Zinuo; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, China
Richel, Aurore ; Université de Liège - ULiège > TERRA Research Centre > Chemistry for Sustainable Food and Environmental Systems (CSFES)
Huang, Minmin; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, China
Gou, Xingchun; Shaanxi Key Laboratory of Brain Disorders & Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, China
Xu, Dan; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, China
Zhang, Min; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, China
Mo, Haizhen; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, China
Hu, Liangbin; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, China
Zhou, Xiaohui; School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, China
Language :
English
Title :
Ferrous sulfate remodels the properties of sodium alginate-based hydrogel and facilitates the healing of wound infection caused by MRSA
NSCF - National Natural Science Foundation of China CSC - China Scholarship Council
Funding text :
This work was supported by the National Natural Science Foundation of China (grant No. 32172321), Innovation Capability Support Program of Shaanxi Province (Program No. 2023-CX-TD-61), and Program of China Scholarship Council (Grant No. 202308610317). XZ was supported by Shenzhen Science and Technology Innovation Commission (grant No. JCYJ20220818100616034), Shenzhen Medical Research Fund (B2302024), Guangdong Basic and Applied Basic Research Foundation (2023B1515120016).
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