Control by plasma potassium concentration of sodium excretion by isolated perfused dog kidney.

The experiments demonstrate that sodium and water rejection by isolated kidney submitted to saline loading is related to hypokalaemia caused by haemodilution. Since there is no change in glomerular filtration, it is demonstrated that sodium rejection is due to decreased tubular reabsorption caused by hypokalaemia. The experimental results suggest that escape from sodium retaining steroids could be related to the combined effect of sodium retention and potassium depletion on sodium tubular reabsorption. They explain also the uncontrollable sodium losses observed in the clinical states of potassium deprivation. © 1967 Springer-Verlag.