Excretion of water and sodum loading by isolated perfused dog kidney.

Isolated dog kidney submitted to artificial perfusion by heparinized blood is able to reject a water and sodium load. The influence of extrarenal hormonal factors is ruled out. Although the interference of lowering of haematocrit and plasma protein level and increase of plasma flow cannot be discarded, other factors related to blood dilution must play a role. Sodium and water rejection depend on a decrease of tubular reabsorption rather than on an increase in glomerular filtration. © 1967 Springer-Verlag.