Keywords :
Chlorides; Dextrans; Serum Albumin; Urea; Sodium; Potassium; Animals; Chlorides/blood; Chlorides/urine; Dextrans/pharmacology; Dogs; Glomerular Filtration Rate; Hematocrit; In Vitro Techniques; Kidney/blood supply; Kidney/drug effects; Kidney/physiology; Natriuresis/drug effects; Osmolar Concentration; Perfusion; Potassium/blood; Potassium/urine; Regional Blood Flow; Serum Albumin/pharmacology; Sodium/blood; Urea/urine; Water-Electrolyte Balance/drug effects; Isolated Kidney; Sodium Excretion; Water Excretion; Physiology; Clinical Biochemistry; Physiology (medical)
Abstract :
[en] The addition of serumalbumin or of dextran reduces sodium and water excretion by isolated kidneys submitted to a saline load. While dextran supplementation produces a considerable drop of glomerular filtration, serumalbumin supplementation induces only slight changes in filtration; a proportional increase of tubular reabsorption is observed. The difference between the response to dextran and serumalbumin may be related to differences in intrarenal blood circulation. Changes in plasma protein concentration play a role in autonomous renal response to saline loading and influence tubular sodium reabsorption. This autonomous renal response is primarily related to plasma dilution. © 1968 Springer-Verlag.
Scopus citations®
without self-citations
15
