Thiol-polyethylene glycol-folic acid (HS-PEG-FA) induced aggregation of Au@Ag nanoparticles: A SERS and extinction UV–Vis spectroscopy combined study

Verdin, Alexandre; Malherbe, Cédric; Sloan-Dennison, Sian; Faulds, Karen; Graham, Duncan; Eppe, Gauthier

doi:10.1016/j.saa.2024.124848

Article (Scientific journals)

Thiol-polyethylene glycol-folic acid (HS-PEG-FA) induced aggregation of Au@Ag nanoparticles: A SERS and extinction UV–Vis spectroscopy combined study

Verdin, Alexandre; Malherbe, Cédric; Sloan-Dennison, Sian et al.

2024 • In Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, p. 124848

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https://hdl.handle.net/2268/320721

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10.1016/j.saa.2024.124848

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Abstract :

[en] Plasmonic colloidal nanoparticles (NPs) functionalised with polymers are widely employed in diverse applications, offering advantages demonstrated over non-functionalised NPs such as enhanced colloidal stability or increased biocompatibility. However, functionalisation with polymers does not always increase the stability of the colloidal system. This work explores the intricate relationship between the functionalisation of plasmonic core@shell Au@Ag nanoparticles (NPs) with thiol-polyethylene glycol-folic acid (HS-PEG-FA) polymer chains and the resulting stability and spectral characteristics of Surface-Enhanced Raman Scattering (SERS) nanotags based on these NPs. We demonstrate that varying levels of HS-PEG-FA grafting influence nanotag stability, with a low level of grafting causing aggregation and subsequently affecting the spectral signature of Raman-reporter molecules attached to the surface of the NP. Electrostatic destabilisation is identified as the primary mechanism driving aggregation, impacting the SERS spectrum of Malachite Green isothiocyanate (MGITC) whose spectral shape is different between the aggregated and non-aggregated NPs. The findings provide valuable insights into NPs stability under different conditions, offering essential considerations for the design and optimisation of SERS nanotags in bio-analytical applications, particularly those involving data processing based on spectral shape, such as in multiplex approaches where experimental spectra are decomposed with several reference components.

Disciplines :

Chemistry

Author, co-author :

Verdin, Alexandre ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique

Malherbe, Cédric ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique

Sloan-Dennison, Sian

Faulds, Karen

Graham, Duncan

Eppe, Gauthier ; Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.)

Language :

English

Title :

Thiol-polyethylene glycol-folic acid (HS-PEG-FA) induced aggregation of Au@Ag nanoparticles: A SERS and extinction UV–Vis spectroscopy combined study

Publication date :

July 2024

Journal title :

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy

ISSN :

1386-1425

Publisher :

Elsevier

Pages :

124848

Peer reviewed :

Peer Reviewed verified by ORBi

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https://api.elsevier.com/content/article/PII:S138614252401014X?httpAccept=text/xml

Available on ORBi :

since 19 July 2024

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