Microstructural associations between locus coeruleus, cortical, and subcortical regions are modulated by astrocyte reactivity: a 7T MRI adult lifespan study.
Beckers, Elise; Van Egroo, Maxime; Ashton, Nicholas Jet al.
GFAP; NODDI; aging; brain microstructure; locus coeruleus; Glial Fibrillary Acidic Protein; Humans; Female; Male; Aged; Middle Aged; Adult; Aged, 80 and over; Magnetic Resonance Imaging/methods; Cerebral Cortex/diagnostic imaging; Brain/diagnostic imaging; Diffusion Magnetic Resonance Imaging/methods; Neurites/physiology; Locus Coeruleus/diagnostic imaging; Astrocytes/physiology; Glial Fibrillary Acidic Protein/metabolism
Abstract :
[en] The locus coeruleus-norepinephrine system plays a key role in supporting brain health along the lifespan, notably through its modulatory effects on neuroinflammation. Using ultra-high field diffusion magnetic resonance imaging, we examined whether microstructural properties (neurite density index and orientation dispersion index) in the locus coeruleus were related to those in cortical and subcortical regions, and whether this was modulated by plasma glial fibrillary acidic protein levels, as a proxy of astrocyte reactivity. In our cohort of 60 healthy individuals (30 to 85 yr, 50% female), higher glial fibrillary acidic protein correlated with lower neurite density index in frontal cortical regions, the hippocampus, and the amygdala. Furthermore, under higher levels of glial fibrillary acidic protein (above ~ 150 pg/mL for cortical and ~ 145 pg/mL for subcortical regions), lower locus coeruleus orientation dispersion index was associated with lower orientation dispersion index in frontotemporal cortical regions and in subcortical regions. Interestingly, individuals with higher locus coeruleus orientation dispersion index exhibited higher orientation dispersion index in these (sub)cortical regions, despite having higher glial fibrillary acidic protein levels. Together, these results suggest that the interaction between locus coeruleus-norepinephrine cells and astrocytes can signal a detrimental or neuroprotective pathway for brain integrity and support the importance of maintaining locus coeruleus neuronal health in aging and in the prevention of age-related neurodegenerative diseases.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Beckers, Elise ; Université de Liège - ULiège > GIGA ; Faculty of Health, Medicine and Life Sciences, Mental Health and Neuroscience Research Institute, Alzheimer Centre Limburg, Maastricht University, 6229 ET Maastricht, The Netherlands
Van Egroo, Maxime; Faculty of Health, Medicine and Life Sciences, Mental Health and Neuroscience Research Institute, Alzheimer Centre Limburg, Maastricht University, 6229 ET Maastricht, The Netherlands ; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA 02129, USA ; Harvard Medical School, Boston, MA 02115, USA
Ashton, Nicholas J; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Gothenburg, 431 41 Mölndal, Sweden ; King's College London, Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute, London SE5 9RT, UK ; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation, London SE5 8AF, UK ; Centre for Age-Related Medicine, Stavanger University Hospital, 4011 Stavanger, Norway
Blennow, Kaj; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Gothenburg, 431 41 Mölndal, Sweden ; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, 431 80 Mölndal, Sweden ; Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, 75013 Paris, France ; Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei 230036, China
Vandewalle, Gilles ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Zetterberg, Henrik; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Gothenburg, 431 41 Mölndal, Sweden ; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, 431 80 Mölndal, Sweden ; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1E 6BT, UK ; UK Dementia Research Institute at UCL, London W1T 7NF, UK ; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China ; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792, USA
Poser, Benedikt A; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, 6229 ER Maastricht, The Netherlands
Jacobs, Heidi I L; Faculty of Health, Medicine and Life Sciences, Mental Health and Neuroscience Research Institute, Alzheimer Centre Limburg, Maastricht University, 6229 ET Maastricht, The Netherlands ; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA 02129, USA ; Harvard Medical School, Boston, MA 02115, USA
Language :
English
Title :
Microstructural associations between locus coeruleus, cortical, and subcortical regions are modulated by astrocyte reactivity: a 7T MRI adult lifespan study.
HE - 101053962 - FLUBIODEM - Fluid Biomarkers for Neurodegenerative Dementias
Name of the research project :
Bluefield Project European Union Joint Programme—Neurodegenerative Disease Research
Funders :
Alzheimer Nederland NIH - National Institutes of Health BrightFocus Foundation Marie Skłodowska-Curie Actions Maastricht Imaging Valley F.R.S.-FNRS - Fonds de la Recherche Scientifique ULiège - University of Liège Swedish Research Council EU - European Union ADDF - Alzheimer's Drug Discovery Foundation Alzheimer's Association CAF - Cure Alzheimer’s Fund Olav Thon Foundation Erling Persson Family Foundation Stiftelsen för Gamla Tjänarinnor Hjärnfonden NIHR BRC - NIHR Imperial Biomedical Research Centre UK DRI - UK Dementia Research Institute
Funding text :
Alzheimer's Association 2021 Zenith Award; ALF-agreement; European Union Joint Program for Neurodegenerative Disorders
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