[en] [en] BACKGROUND: Increasing evidence points to a pathophysiological role for the cerebellum in Parkinson's disease (PD). However, regional cerebellar changes associated with motor and non-motor functioning remain to be elucidated.
OBJECTIVE: To quantify cross-sectional regional cerebellar lobule volumes using three dimensional T1-weighted anatomical brain magnetic resonance imaging from the global ENIGMA-PD working group.
METHODS: Cerebellar parcellation was performed using a deep learning-based approach from 2487 people with PD and 1212 age and sex-matched controls across 22 sites. Linear mixed effects models compared total and regional cerebellar volume in people with PD at each Hoehn and Yahr (HY) disease stage, to an age- and sex- matched control group. Associations with motor symptom severity and Montreal Cognitive Assessment scores were investigated.
RESULTS: Overall, people with PD had a regionally smaller posterior lobe (dmax = -0.15). HY stage-specific analyses revealed a larger anterior lobule V bilaterally (dmax = 0.28) in people with PD in HY stage 1 compared to controls. In contrast, smaller bilateral lobule VII volume in the posterior lobe was observed in HY stages 3, 4, and 5 (dmax = -0.76), which was incrementally lower with higher disease stage. Within PD, cognitively impaired individuals had lower total cerebellar volume compared to cognitively normal individuals (d = -0.17).
CONCLUSIONS: We provide evidence of a dissociation between anterior "motor" lobe and posterior "non-motor" lobe cerebellar regions in PD. Whereas less severe stages of the disease are associated with larger motor lobe regions, more severe stages of the disease are marked by smaller non-motor regions.
Research Center/Unit :
GIGA CRC In vivo Imaging-MoVeRe - ULiège
Disciplines :
Neurology
Author, co-author :
Kerestes, Rebecca ; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia
Laansma, Max A ; Department Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands ; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands
Owens-Walton, Conor; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA
Perry, Andrew; Monash Bioinformatics Platform, Monash University, Melbourne, Victoria, Australia
van Heese, Eva M; Department Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands ; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands
Al-Bachari, Sarah; Faculty of Health and Medicine, The University of Lancaster, Lancaster, United Kingdom
Anderson, Tim J; New Zealand Brain Research Institute, Christchurch, New Zealand ; Neurology Department, Te Whatu Ora - Health New Zealand Waitaha Canterbury, Christchurch, New Zealand
Assogna, Francesca; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy
Aventurato, Ítalo K; Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil ; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil
van Balkom, Tim D ; Department Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands ; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands ; Department Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Berendse, Henk W; Department Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
van den Berg, Kevin R E; Department of Neurology and Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands ; Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
Betts, Rebecca; School of Physics and Astronomy, Faculty of Science and Engineering, The University of Manchester, Manchester, United Kingdom
Brioschi, Ricardo; Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil
Carr, Jonathan; Division of Neurology, Tygerberg Hospital and Stellenbosch University, Cape Town, South Africa
Cendes, Fernando ; Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil ; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil
Clark, Lyles R; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
Dalrymple-Alford, John C; New Zealand Brain Research Institute, Christchurch, New Zealand ; Department of Medicine, University of Otago, Christchurch, New Zealand ; School of Psychology, Speech and Hearing, University of Canterbury, Christchurch, New Zealand
Dirkx, Michiel F; Department of Neurology and Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Druzgal, Jason; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA
Durrant, Helena; School of Physics and Astronomy, Faculty of Science and Engineering, The University of Manchester, Manchester, United Kingdom
Emsley, Hedley C A; Lancaster Medical School, Lancaster University, Lancaster, United Kingdom ; Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
Garraux, Gaëtan ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie du système nerveux
Haroon, Hamied A; Division of Psychology, Communication and Human Neuroscience, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
Helmich, Rick C ; Department of Neurology and Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands ; Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
van den Heuvel, Odile A; Department Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands ; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands ; Department Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
João, Rafael B; Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil ; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil
Johansson, Martin E; Department of Neurology and Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Khachatryan, Samson G; Department of Neurology and Neurosurgery, National Institute of Health, Yerevan, Armenia ; Centers for Sleep and Movement Disorders, Somnus Neurology Clinic, Yerevan, Armenia
Lochner, Christine; Department of Psychiatry, SA MRC Unit on Risk and Resilience in Mental Disorders, Stellenbosch University, Cape Town, South Africa
McMillan, Corey T; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
Melzer, Tracy R ; New Zealand Brain Research Institute, Christchurch, New Zealand ; Department of Medicine, University of Otago, Christchurch, New Zealand ; School of Psychology, Speech and Hearing, University of Canterbury, Christchurch, New Zealand
Mosley, Philip E; Clinical Brain Networks Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia ; The Australian eHealth Research Centre, CSIRO Health and Biosecurity, Brisbane, Queensland, Australia
Newman, Benjamin; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA
Opriessnig, Peter; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria
Parkes, Laura M ; Division of Psychology, Communication and Human Neuroscience, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom ; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance and University of Manchester, Manchester, United Kingdom
Pellicano, Clelia; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy
Piras, Fabrizio; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy
Pitcher, Toni L ; New Zealand Brain Research Institute, Christchurch, New Zealand ; Department of Medicine, University of Otago, Christchurch, New Zealand
Poston, Kathleen L ; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA
Rango, Mario; Excellence Center for Advanced MR Techniques and Parkinson's Disease Center, Neurology unit, Fondazione IRCCS Cà Granda Maggiore Policlinico Hospital, University of Milan, Milan, Italy ; Department of Neurosciences, Neurology Unit, Fondazione Ca' Granda, IRCCS, Ospedale Policlinico, University of Milan, Milano, Italy
Roos, Annerine; Department of Psychiatry and Neuroscience Institute, SA MRC Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa
Rummel, Christian; Support Center for Advanced Neuroimaging, (SCAN) University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Schmidt, Reinhold; Department of Neurology, Medical University of Graz, Graz, Austria
Schwingenschuh, Petra; Department of Neurology, Medical University of Graz, Graz, Austria
Silva, Lucas S; Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil ; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil
Smith, Viktorija; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA
Squarcina, Letizia; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
Stein, Dan J; Department of Psychiatry and Neuroscience Institute, SA MRC Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa
Tavadyan, Zaruhi; Department of Neurology and Neurosurgery, National Institute of Health, Yerevan, Armenia ; Centers for Sleep and Movement Disorders, Somnus Neurology Clinic, Yerevan, Armenia
Tsai, Chih-Chien; Healthy Aging Research Center, Chang Gung University, Taoyuan City, Taiwan
Vecchio, Daniela; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy
Vriend, Chris; Department Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands ; Department Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands ; Amsterdam Neuroscience, Brain Imaging, Amsterdam, The Netherlands
Wang, Jiun-Jie ; Healthy Aging Research Center, Chang Gung University, Taoyuan City, Taiwan ; Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan City, Taiwan ; Department of Diagnostic Radiology, Chang Gung Memorial Hospital Keelung Branch, Keelung City, Keelung, Taiwan ; Department of Chemical Engineering, Ming-Chi University of Technology, New Taipei City, Taiwan
Wiest, Roland; Support Center for Advanced Neuroimaging, (SCAN) University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Yasuda, Clarissa L; Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil ; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil
Young, Christina B; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA
Jahanshad, Neda; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA
Thompson, Paul M; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA
van der Werf, Ysbrand D; Department Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands ; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands
Harding, Ian H ; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia ; Monash Biomedical Imaging, Monash University, Melbourne, Victoria, Australia
T.J.A. is funded by Health Research Council New Zealand grants (20/538, 21/165). H.W.B. is funded by the Netherlands Organisation for Health Research and Development (ZonMw) and The Michael J. Fox Foundation. F.C. is funded by São Paulo Research Foundation (FAPESP) grant 2013/07559‐3. M.D. is funded by a grant from ParkinsonNL (P2023‐14). H.C.A.E. is supported by Lancashire Teaching Hospitals NHS Foundation Trust. J.D. is supported by an ENIGMA‐PD R01 grant (R01NS107513). J.D.A. is funded the Health Research Council of New Zealand (20/538), Marsden Fund New Zealand (UOC2105), Neurological Foundation of New Zealand (2232 PRG), and the Research and Education Trust Pacific Radiology (MRIJDA). G.G. is funded by a National Fund for Scientific Research grant (Belgian fund for Scientific Research; University of Liege Grant (Fonds Rahier). R.C.H. is funded by The Michael J. Fox Foundation and the Netherlands Organization for Scientific Research. I.H.H. is funded by grants from the National Health and Medical Research Council, Friedreich Ataxia Research Alliance, and National Ataxia Foundation and Telethon Fondazione. N.J. is funded by grants R01AG059874, R01MH117601, R01NS107513, and P41EB015922. P.E.M. receives salary from a job as neuropsychiatrist at St. Andrew's War Memorial Hospital, Brisbane, and salary as research scientist at Commonwealth Scientific and Industrial Research Organization. C.M. is funded by the National Institutes of Health (NIH) R01 grants NIH R01AG066152, NIH P01AG066597, NIH U54NS092091, NIH U01NS107027, NIH R01NS109260, NIH U19AG062418, Pennsylvania Department of Health 2019NF4100087335, NIH R01 AG070885, NIH P30AG072979, NIH R01NS107513, NIH R01 AG076832, and NIH R01AG080734. T.R.M. is funded by a Health Research Council grant (20/538). K.L.P. is funded by The Michael J. Fox Foundation for Parkinson's Research, the Lewy Body Dementia Association, the Alzheimer's Drug Discovery Foundation, and the NIH grant (6440). F.P. is funded by the Italian Ministry of Health, grant number RF‐2019‐12370182. C.R. is funded by SNF grants 204593 and 180365. D.J.S. is funded by the South African Medical Research Council. C.Y. is funded by the NIH, Alzheimer's Association, and New Vision Research. L.M.P. is funded by the University of Manchester and UK Research and Innovation. T.P. is funded by a Health Research Council grant (21/165). O.A.v.d.H. is funded by the Netherlands Organisation for Health Research and Development (ZonMw), Hersenstichting, and the National Institute of Mental Health. C.V. is funded by The Michael J. Fox Foundation (grants 6440). D.V. is funded by the Italian Ministry of Health, Ricerca Corrente 2023. J.W. is funded by the National Science and Technology Council, Taiwan. R.W. is funded by Swiss National Science Foundation (SNF) grant 180365. C.Y. is funded by São Paulo Research Foundation FAPESP‐BRAINN grant 2013‐07559‐3 and National Council for Scientific and Technological Development (CNPQ) (315953/2021‐7) National Council for Scientific and Technological Development. C.L. is funded by the South African Medical Research Council.We thank all the students and research assistants for their contribution to the data collection and analysis, in particular Lennart Zegerius and Liska Scheffers. We thank Sophia Thomopoulos for her continuous administrative support. In memoriam of Gianfranco Spalletta (August 8, 1962–March 18, 2023). Open access publishing facilitated by Monash University, as part of the Wiley - Monash University agreement via the Council of Australian University Librarians.
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