Paper published in a journal (Scientific congresses and symposiums)
INDEPENDENT PATIENT DATA META-ANALYSIS OF PROPHYLACTIC MESH PLACEMENT FOR INCISIONAL HERNIA PREVENTION (AFTER ABDOMINAL AORTIC ANEURYSM SURGERY): A COLLABORATIVE EUROPEAN HERNIA SOCIETY PROJECT (I-PREVENT-AAA)
[en] Abstract
Introduction
Incisional hernia (IH) is a prevalent and potentially dangerous complication after abdominal surgery, especially in high-risk groups. Prophylactic mesh augmentation (PMA) of the abdominal wall has been studied as a preventive measure for IH-formation, but strong recommendations are lacking. Our primary aim was to evaluate the effectiveness of the use of PMA after open abdominal aortic aneurysm (AAA)-surgery for the prevention of IH by performing an individual patient-data meta-analysis (IPDMA). Secondary aims include evaluation of postoperative complications, and identification of subgroups that benefit most from PMA.
Methods
A systematic literature search to identify Randomized-Controlled Trials (RCTs) that compare PMA after open AAA surgery to primary suturing (PS), was conducted. Lead authors of eligible studies were asked to share individual participant-data. A one-stage analysis was performed and Cox-regression analyses were used to assess time-to-event outcomes.
Results
Five RCTs were included in our IPDMA, which resulted in 488 analysed patients. PMA resulted in a Hazard Ratio (HR) of 0.25 (95%CI 0.12–0.50) for the reduction of IH occurrence. No significant differences were present when comparing onlay with sublay mesh (HR 0.56, 95%CI 0.24–1.28). Patients treated with an onlay mesh had significantly more seroma formation in comparison to PS (OR 22.1,95%CI 1.88–259.58) and patients with a sublay mesh had fewer re-operations than those treated with PS (OR 0.47,95%CI 0.43–0.51). Subgroup analyses showed the effectiveness of PMA in various subgroups (e.g., high BMI patients).
Conclusion
PMA after open AAA surgery is an effective measure to reduce IH formation in a wide variety of patients.
Disciplines :
Surgery
Author, co-author :
van den Berg, R; Department of Surgery, Erasmus University Medical Centre , Rotterdam , Netherlands
Den Hartog, F P J; Department of Surgery, Erasmus University Medical Centre , Rotterdam , Netherlands
Bali, C; Department of Surgery, University Hospital of Ioannina , Ioannina , Greece
Matsagkas, M; Department of Vascular Surgery, University of Thessaly , Larissa , Greece
Bevis, P M; Department of Vascular Surgery, North Bristol NHS Trust , UK
Earnshaw, J J; Department of Vascular Surgery, Gloucestershire Health and Care NHS Foundation Trust , UK
Debus, E S; Department of Vascular Medicine, University Medical Center Hamburg-Eppendorf University Heart & Vascular Center , Eppendorf, Hamburg , Germany
Honig, S; Department of Vascular Surgery, Hospital Robert Schuman Kirchberg Hospital , Luxembourg , Luxembourg
Berrevoet, F; Department of General and Hepatobiliary Surgery and Liver Transplantation, Ghent University Hospital , Ghent , Belgium
Detry, Olivier ; Université de Liège - ULiège > Département des sciences cliniques > Pathologie chirurgicale abdominale et endocrinienne
Stabilini, C; Department of Surgical Sciences, University of Genoa , Genoa , Italy
Muysoms, F E; Department of Surgery, AZ Maria Middelares Hospital , Ghent , Belgium
Tanis, P J; Department of Surgery, Erasmus University Medical Centre , Rotterdam , Netherlands
Diener, H; Department of Vascular Medicine, University Medical Center Hamburg-Eppendorf University Heart & Vascular Center , Eppendorf, Hamburg , Germany
Kölbel, T; Department of Vascular Medicine, University Medical Center Hamburg-Eppendorf University Heart & Vascular Center , Eppendorf, Hamburg , Germany
Reinpold, W; Hamburg Hernia Centre, Department of Hernia and Abdominal Wall Surgery, Helios Mariahilf Hospital Hamburg, Teaching Hospital of the University of Hamburg , Hamburg , Germany
Zapf, A; Institut für Medizinische Biometrie und Epidemiologie, Universitätsklinikum Hamburg-Eppendorf , Hamburg , Germany
Bibiza-Freiwald, E; Institut für Medizinische Biometrie und Epidemiologie, Universitätsklinikum Hamburg-Eppendorf , Hamburg , Germany
Georvasili, V K; Department of Surgery, University Hospital of Ioannina , Ioannina , Greece
INDEPENDENT PATIENT DATA META-ANALYSIS OF PROPHYLACTIC MESH PLACEMENT FOR INCISIONAL HERNIA PREVENTION (AFTER ABDOMINAL AORTIC ANEURYSM SURGERY): A COLLABORATIVE EUROPEAN HERNIA SOCIETY PROJECT (I-PREVENT-AAA)
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