Keywords :
Neurotransmitter Agents; Cell Movement; Humans; Organoids; Interneurons; Neurogenesis; Neuroscience (all); Molecular Biology; Biochemistry, Genetics and Molecular Biology (all); Immunology and Microbiology (all); General Immunology and Microbiology; General Biochemistry, Genetics and Molecular Biology; General Neuroscience
Abstract :
[en] While key developmental functions of neurotransmitters have been described in rodent neural progenitors, there is a lack of understanding of their roles in the human fetal brain. A new study published in The EMBO Journal demonstrates that human cortical interneurons that are moving in fused brain organoids express a large repertoire of neurotransmitter receptors whose activation fine tunes selective migration strategies.
Funding text :
The work in the Nguyen laboratory is supported by the F.R.S.‐F.N.R.S. (Synet; EOS 0019118F‐RG36), the Fonds Leon Fredericq, the Fondation Médicale Reine Elisabeth, the Fondation Simone et Pierre Clerdent, the Belgian Science Policy (IAP‐VII network P7/20), and the ERANET Neuron STEM‐MCD and NeuroTalk. A.B., M.J.‐T., are postdoctoral researchers of the F.R.S.‐F.N.R.S. and L.N. is director of the F.R.S‐F.N.R.S.The work in the Nguyen laboratory is supported by the F.R.S.-F.N.R.S. (Synet; EOS 0019118F-RG36), the Fonds Leon Fredericq, the Fondation Médicale Reine Elisabeth, the Fondation Simone et Pierre Clerdent, the Belgian Science Policy (IAP-VII network P7/20), and the ERANET Neuron STEM-MCD and NeuroTalk. A.B., M.J.-T., are postdoctoral researchers of the F.R.S.-F.N.R.S. and L.N. is director of the F.R.S-F.N.R.S.
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