[en] [en] BACKGROUND: Chemotherapy-associated liver injuries (CALI) have been associated with poor postoperative outcome after open liver resection. To date, no data concerning any correlation of CALI and laparoscopic liver resection (LLR) are available. In the present study, we evaluated the impact of CALI on short-term outcomes in patients undergoing LLR.
MATERIALS AND METHODS: All patients who underwent in our department LLR for colorectal liver metastases (CRLM) from 2000 to 2016 were retrospectively reviewed. Patients were divided in 4 groups according to their pathological histology. In group 1 patients had normal liver parenchyma. Group 2 included patients with steatosis and steatohepatitis. Patients with sinusoidal obstruction syndrome (SOS) and nodular regenerative hyperplasia (NRH) were allocated to group 3, whereas the remaining with fibrosis and cirrhosis, were assigned to group 4.
RESULTS: A total of 490 LLR for CRLM were included in the study. Perioperative details and morbidity did not differ significantly between the four groups. Subgroup analysis showed that NRH was associated with higher amount of blood loss (p = 0.043), overall (p = 0.021) and liver-specific morbidity (p = 0.039).
CONCLUSION: NRH is a severe form of CALI that may worsen the short-term outcomes of patients undergoing LLR for CRLM. However, the remaining forms of CALI do not have a significant impact on perioperative outcomes after LLR.
Disciplines :
Surgery
Author, co-author :
Neuberg, Maud ; Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie abdo, sénologique, endocrine et de transplantation ; Department of Digestive Oncologic and Metabolic Surgery, Institut Mutualiste Montsouris, Université Paris Descartes, 42 boulevard Jourdan, 75014, Paris, France
Triantafyllidis, Ioannis; Department of Digestive Oncologic and Metabolic Surgery, Institut Mutualiste Montsouris, Université Paris Descartes, 42 boulevard Jourdan, 75014, Paris, France ; Department of General Surgery, General Hospital of Veria, Veria, Greece
Lefevre, Marine; Department of Pathology, Institut Mutualiste Montsouris, 42 boulevard Jourdan, 75014, Paris, France
Bennamoun, Mostefa; Department of Oncology, Institut Mutualiste Montsouris, 42 boulevard Jourdan, 75014, Paris, France
Sarran, Anthony; Department of Radiology, Institut Mutualiste Montsouris, 42 boulevard Jourdan, 75014, Paris, France
Beaussier, Marc; Department of Digestive Oncologic and Metabolic Surgery, Institut Mutualiste Montsouris, Université Paris Descartes, 42 boulevard Jourdan, 75014, Paris, France
Louvet, Christophe; Department of Oncology, Institut Mutualiste Montsouris, 42 boulevard Jourdan, 75014, Paris, France
Gayet, Brice; Department of Digestive Oncologic and Metabolic Surgery, Institut Mutualiste Montsouris, Université Paris Descartes, 42 boulevard Jourdan, 75014, Paris, France
Fuks, David ; Department of Digestive Oncologic and Metabolic Surgery, Institut Mutualiste Montsouris, Université Paris Descartes, 42 boulevard Jourdan, 75014, Paris, France. david.fuks@imm.fr
Language :
English
Title :
Does Chemotherapy-Induced Liver Injury Impair Postoperative Outcomes After Laparoscopic Liver Resection for Colorectal Metastases?
Jones RP, Kokudo N, Folprecht G, et al. Colorectal liver metastases: a critical review of state of the art. Liver Cancer 2017;6(1):66–71. DOI: 10.1159/000449348
Beamish P, Lemke M, Li J, et al. Validation of clinical risk score for colorectal liver metastases resected in a contemporary multicenter cohort. HPB (Oxford). 2017; 19(8):675-681. DOI: 10.1016/j.hpb.2017.03.010
Adam R, Delvart V, Pascal G, et al. Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: a model to predict long-term survivam. Ann Surg 2004;240:644-657. DOI: 10.1097/01.sla.0000141198.92114.f6
Allen PJ, Kemeny N, Jarnagin W, et al. Importance of response to neoadjuvant chemotherapy in patients undergoing resection of synchronous colorectal liver metastases. J Gastrointest Surg 2003;7:109-115. DOI: 10.1016/S1091-255X(02)00121-X
Viganò L, Capussotti L, De Rosa G, et al. Liver resection for colorectal metastases after chemotherapy: impact of chemotherapy-related liver injuries, pathological tumor response, and micrometastases on long-term survival. Ann Surg. 2013;258(5):731–40. DOI: 10.1097/SLA.0b013e3182a6183e
Zeiss J, Merrick HW, Savolaine ER, et al. Fatty liver change as a result of hepatic artery infusion chemotherapy. Am J Clin Oncol 1990;13:156-160. DOI: 10.1097/00000421-199004000-00013
Peppercorn PD, Reznek RH, Wilson P, et al. Demonstration of hepatic steatosis by computerized tomography in patients receiving 5-fluorouracil-based therapy for advanced colorectal cancer. Br J Cancer 1998;77:2008-2011. DOI: 10.1038/bjc.1998.333
Rubbia-Brandt L, Audard V, Sartoretti P, et al. Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer. Ann Oncol 2004;15:460–466. DOI: 10.1093/annonc/mdh095
Vauthey JN, Pawlik TM, Ribero D, et al. Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases. J Clin Oncol 2006;24:2065-2072. DOI: 10.1200/JCO.2005.05.3074
Nakano H, Oussoultzoglou E, Rosso E, et al. Sinusoidal injury increases morbidity after major hepatectomy in patients with colorectal liver metastases receiving preoperative chemotherapy. Ann Surg 2008;247:118-124. DOI: 10.1097/SLA.0b013e31815774de
Scuderi V, Barkhatov L, Montalti R, et al. Outcome after laparoscopic and open resections of posterosuperior segments of the liver. Br J Surg. 2017; 104(6):751–759. DOI: 10.1002/bjs.10489
Allard M-A, Cunha AS, Gayet B, et al. Early and long-term oncological outcomes after laparoscopic resection for colorectal liver metastases: a propensity score-based analysis. Ann Surg. 2015; 262(5):794–802. DOI: 10.1097/SLA.0000000000001475
Fretland AA, Dagenborg VJ, Bjornelv GMW, et al. Laparoscopic versus open resection for colorectal liver metastases. Ann Surg. 2017; 267:199–207. DOI: 10.1097/SLA.0000000000002353
Nomi T, Fuks D, Kawaguchi Y, et al. Laparoscopic major hepatectomy for colorectal liver metastases in elderly patients: a single-center, case-matched study. Surg Endosc. 2015; 29(6):1368–1375. DOI: 10.1007/s00464-014-3806-1
Nomi T, Fuks D, Kawaguchi Y, et al. Learning curve for laparoscopic major hepatectomy. Br J Surg. 2015; 102(7):796–804. DOI: 10.1002/bjs.9798
Ishizawa T, Gumbs AA, Kokudo N, et al. Laparoscopic segmentectomy of the liver: from segment I to VIII. Ann Surg. 2012; 256(6):959–964. DOI: 10.1097/SLA.0b013e31825ffed3
Dindo D, Demartines N, Clavien P-A. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004; 240(2):205–213. DOI: 10.1097/01.sla.0000133083.54934.ae
Balzan S, Belghiti J, Farges O, et al. The “50–50 criteria” on postoperative day 5: an accurate predictor of liver failure and death after hepatectomy. Ann Surg. 2005; 242(6):824–829. DOI: 10.1097/01.sla.0000189131.90876.9e
Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41(6):1313–21. DOI: 10.1002/hep.20701
Wanless IR. Micronodular transformation (nodular regenerative hyperplasia) of the liver: a report of 64 cases among 2,500 autopsies and a new classification of benign hepatocellular nodules. Hepatology. 1990;11(5):787–97. DOI: 10.1002/hep.1840110512
Bedossa P, Poynard T. METAVIR cooperative study group. An algorithm for the grading of activity in chronic hepatitis C. Hepatology 1996;24:289-93. DOI: 10.1002/hep.510240201
Neal CP, Nana GR, Jones M, et al. Repeat hepatectomy is independently associated with favorable long-term outcome in patients with colorectal liver metastases. Cancer Med 2017;6(2):331–338. DOI: 10.1002/cam4.872
Adam R, Pascal G, Castaing D, et al: Tumor progression while on chemotherapy: A contraindication to liver resection for multiple colorectal metastases? Ann Surg 2004;240: 1052-1061. DOI: 10.1097/01.sla.0000145964.08365.01
Parikh AA, Gentner B, Wu TT, et al. Perioperative complications in patients undergoing major liver resection with or without neoadjuvant chemotherapy. J Gastrointest Surg 2003;7:1082-1088. DOI: 10.1016/j.gassur.2003.08.005
Rubbia-Brandt L, Lauwers GY, Wang H, et al. Sinusoidal obstruction syndrome and nodular regenerative hyperplasia are frequent oxaliplatin-associated liver lesions and partially prevented by bevacizumab in patients with hepatic colorectal metastasis. Histopathology 2010; 56: 430–439. DOI: 10.1111/j.1365-2559.2010.03511.x
Viganò L, Rubbia-Brandt L, De Rosa G, et al. Nodular regenerative hyperplasia in patients undergoing liver resection for colorectal metastases after chemotherapy: risk factors, preoperative assessment and clinical impact. Ann Surg Oncol 2015; 22: 4149–4157. DOI: 10.1245/s10434-015-4533-0
Khan AZ, Morris-Stiff G, Makuuchi M. Patterns of chemotherapy-induced hepatic injury and their implications for patients undergoing liver resection for colorectal liver metastases. J Hepatobiliary Pancreat Surg 2009; 16: 137–144. DOI: 10.1007/s00534-008-0016-z
Pilgrim CH, Satgunaseelan L, Pham A, et al. Correlations between histopathological diagnosis of chemotherapy-induced hepatic injury, clinical features, and perioperative morbidity. HPB 2012; 14: 333–340. DOI: 10.1111/j.1477-2574.2012.00454.x
Viganò L, Ravarino N, Ferrero A, et al. Prospective evaluation of accuracy of liver biopsy findings in the identification of chemotherapyassociated liver injuries. Arch Surg 2012; 147: 1085–1091. DOI: 10.1001/archsurg.2012.1867
Komori H, Beppu T, Baba Y, et al. Histological liver injury and surgical outcome after FOLFOX followed by a hepatectomy for colorectal liver metastases in Japanese patients. Int J Clin Oncol 2010; 15: 263–270. DOI: 10.1007/s10147-010-0046-9
Pawlik TM, Olino K, Gleisner AL, et al. Preoperative chemotherapy for colorectal liver metastases: impact on hepatic histology and postoperative outcome. J Gastrointest Surg 2007; 11: 860–868. DOI: 10.1007/s11605-007-0149-4
Sahajpal A, Vollmer CM, Dixon E, et al. Chemotherapy for colorectal cancer prior to liver resection for colorectal cancer hepatic metastases does not adversely affect peri-operative outcomes. J Surg Oncol 2007; 95: 22–27. DOI: 10.1002/jso.20632
Kandutsch S, Klinger M, Hacker S, et al. Patterns of hepatotoxicity after chemotherapy for colorectal cancer liver metastases. Eur J Surg Oncol 2008; 34: 1231–1236. DOI: 10.1016/j.ejso.2008.01.001
Fulco RA, Costa C, Germano MP, et al: Hepatotoxicity of camptothecin derivatives in a primary culture system of rat hepatocytes. J Chemother 2000;12:345-351. DOI: 10.1179/joc.2000.12.4.345
Fernandez FG, Ritter J, Goodwin JW, et al: Effect of steatohepatitis associated with irinotecan or oxaliplatin pretreatment on resectability of hepatic colorectal metastases. J Am Coll Surg 2005;200: 845-853. DOI: 10.1016/j.jamcollsurg.2005.01.024
Sanyal AJ, Campbell-Sargent C, Mirshahi F, et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001; 120: 1183–1192. DOI: 10.1053/gast.2001.23256
Cortez-Pinto H, Chatham J, Chacko VP, et al. Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study. JAMA 1999; 282: 1659–1664. DOI: 10.1001/jama.282.17.1659
Yang SQ, Lin HZ, Mandal AK, et al. Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology. Hepatology 2001; 34: 694–706. DOI: 10.1053/jhep.2001.28054
McCormack L, Petrowsky H, Jochum W, et al. Hepatic steatosis is a risk factor for postoperative complications after major hepatectomy: a matched case–control study. Ann Surg 2007; 245: 923–930. DOI: 10.1097/01.sla.0000251747.80025.b7
Kooby DA, Fong Y, Suriawinata A, et al. Impact of steatosis on perioperative outcome following hepatic resection. J Gastrointest Surg 2003;7:1034-1044. DOI: 10.1016/j.gassur.2003.09.012
Morris-Stiff G, White AD, Gomez D, et al. Nodular regenerative hyperplasia (NRH) complicating oxaliplatin chemotherapy in patients undergoing resection of colorectal liver metastases. Eur J Surg Oncol. 2014 Aug;40(8):1016-20. DOI: 10.1016/j.ejso.2013.09.015
Schiffer E, Frossard JL, Rubbia-Brandt L, et al. Hepatic regeneration is decreased in a rat model of sinusoidal obstruction syndrome. J Surg Oncol 2009; 99: 439–446. DOI: 10.1002/jso.21276
Zhao J, van Mierlo KMC, Gómez-Ramírez J, Chemotherapy-Associated Liver Injury (CALI) consortium et al; Systematic review of the influence of chemotherapy-associated liver injury on outcome after partial hepatectomy for colorectal liver metastases. Br J Surg. 2017 Jul;104(8):990-1002. DOI: 10.1002/bjs.10572
M.J. Overman, D.M. Maru, C. Charnsangavej, et al. Oxaliplatin-mediated increase in spleen size as a biomarker for the development of hepatic sinusoidal injury, J. Clin. Oncol. 2010; 28 (15):2549e2555. DOI: 10.1200/JCO.2009.27.5701
K. Imai, Y. Emi, K.I. Iyama, et al. Study Group of Clinical Cancer ancillary, Splenic volume may be a useful indicator of the protective effect of bevacizumab against oxaliplatin-induced hepatic sinusoidal obstruction syndrome, Eur. J. Surg. Oncol. 2014;40 (5):559e566. DOI: 10.1016/j.ejso.2013.12.009
D. Takeda, H. Nitta, T. Takahara, et al. Effect of preoperative chemotherapy on postoperative liver regeneration following hepatic resection as estimated by liver volume, World J. Surg. Oncol. 2013; 11:65. DOI: 10.1186/1477-7819-11-65
Bismuth H. Surgical anatomy and anatomical surgery of the liver. World J Surg 1982;6: 3–9. DOI: 10.1007/BF01656368
Jayaraman S, Khakhar A, Yang H, et al. The association between central venous pressure, pneumoperitoneum, and venous carbon dioxide embolism in laparoscopic hepatectomy, Surgical Endoscopy and Other Interventional Techniques. 2009;23:2369-2373. DOI: 10.1007/s00464-009-0359-9
Otsuka Y, Katagiri T, Ishii J, et al. Gas embolism in laparoscopic hepatectomy: what is the optimal pneumoperitoneal pressure for laparoscopic major hepatectomy?, Journal of Hepato-Biliary-Pancreatic Sciences. 2013;20: 137-140. DOI: 10.1007/s00534-012-0556-0
Kawaguchi Y, Nomi T, Fuks D, et al. Hemorrhage control for laparoscopic hepatectomy: technical details and predictive factors for intraoperative blood loss. Surg Endosc. 2016 Jun;30(6):2543-51. DOI: 10.1007/s00464-015-4520-3
Stevenson HL, Prats MM, Sasatomi E. Chemotherapy-induced Sinusoidal Injury (CSI) score: a novel histologic assessment of chemotherapy-related hepatic sinusoidal injury in patients with colorectal liver metastasis. BMC Cancer. 2017 Jan 7;17(1):35. DOI: 10.1186/s12885-016-2998-2
Nordlinger B, Sorbye H, Collette L, et al. Final results of the EORTC intergroup randomized phase III study 40983 [EPOC] evaluating the benefit of peri-operative FOLFOX4 chemotherapy for patients with potentially resectable colorectal cancer liver metastases. J Clin Oncol (Meeting Abstracts) 2007;25. LBA5.
