Aging; Bone architecture; Bone density; Fat mass; Obesity; Male; Humans; Aged; Cross-Sectional Studies; Bone Density; Absorptiometry, Photon; Independent Living; Obesity/complications; Geriatrics and Gerontology
Abstract :
[en] [en] BACKGROUND: Osteoporosis is an age-related condition that can lead to fragility fractures and other serious consequences. The literature data on the impact of obesity on bone health are contradictory. The main reasons for this discrepancy could be the imperfect nature of the body mass index (BMI) as a marker of obesity, the metabolic status (inflammation and metabolically healthy obesity), and/or heterogeneity in bone variables and architecture or sex.
AIMS: To examine the relationship between bone variables and three validated obesity criteria.
METHODS: In this cross-sectional study, participants were classified as obese according to their BMI, waist circumference (WC), and fat mass (FM). Bone variables and architecture were assessed using dual-energy X-ray absorptiometry and peripheral quantitative computed tomography, respectively.
RESULTS: One hundred sixty-eight adults aged 55 or over (men: 68%) were included. 48 (28%) participants were obese according to the BMI, with 108 (64%) according to the FM, and 146 (87%) according to the WC. Bone variables were positively correlated with WC and BMI (Pearson's r = 0.2-0.42). In men only, the obesity measures were negatively correlated with cortical bone density (Pearson's r = - 0.32 to - 0.19) and positively correlated with cortical bone area (Pearson's r = 0.22-0.39).
CONCLUSION: Our findings indicate that independent of sex and obesity criteria, when significant, being obese seems to lead to higher bone parameters than being non-obese, except for cortical bone density. Thus, in the obese population, assessing cortical density might help the physician to identify bone alteration. Further researches are needed to confirm our findings.
Disciplines :
Geriatrics
Author, co-author :
Lemoine, L ; Division of Geriatric Medicine, Tours University Medical Centre, Tours, France. lea.lemoine@univ-tours.fr ; CHRU Tours - Service de Médecine Aigue Gériatrique, Hôpital Bretonneau, 2 Boulevard Tonnellé, 37044, Tours Cedex 9, France. lea.lemoine@univ-tours.fr
Buckinx, Fanny ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé ; Département des Sciences de l'activité Physique, Faculté des Sciences, Groupe de recherche en Activité Physique Adaptée (GRAPA), Université du Québec À Montréal, Montreal, QC, Canada ; Centre de recherche de l'Institut, Université de Gériatrie de Montréal, Montreal, QC, Canada
Aidoud, A; Division of Geriatric Medicine, Tours University Medical Centre, Tours, France ; EA4245 T2i, Université de Tours, Tours, France
Leroy, V; Division of Geriatric Medicine, Tours University Medical Centre, Tours, France
Fougère, B; Division of Geriatric Medicine, Tours University Medical Centre, Tours, France ; EA 7505 Education, Ethics, Health, Tours University, Tours, France
Aubertin-Leheudre, M; Département des Sciences de l'activité Physique, Faculté des Sciences, Groupe de recherche en Activité Physique Adaptée (GRAPA), Université du Québec À Montréal, Montreal, QC, Canada ; Centre de recherche de l'Institut, Université de Gériatrie de Montréal, Montreal, QC, Canada
Language :
English
Title :
Relationships between obesity markers and bone parameters in community-dwelling older adults.
Publication date :
29 February 2024
Journal title :
Aging Clinical and Experimental Research
ISSN :
1594-0667
eISSN :
1720-8319
Publisher :
Springer Science and Business Media Deutschland GmbH, Germany
This research did not receive any specific funding from agencies or organizations in the public, commercial, or not-for-profit sectors. MAL is supported by a Chercheur Boursier Senior salary award from the Fonds de Recherche du Québec en Santé (FRQS). FB is supported by a fellowship from the Canadian Institute of Health Research (CIHR) and FRQS.We sincerely thank all the participants. We are also grateful to other members of the Laboratoire du Muscle et de sa Function for their technical assistance with data collection. We thank David Fraser for his comments on the manuscript.
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