Effects of Major Epigenetic Factors on Systemic Lupus Erythematosus.

DNA methylation; Epigenesis; Histones; microRNAs; Systemic lupus erythematosus; MicroRNAs; DNA Methylation/physiology; Epigenesis, Genetic/physiology; Humans; Lupus Erythematosus, Systemic/diagnosis; Lupus Erythematosus, Systemic/genetics; Lupus Erythematosus, Systemic/metabolism; MicroRNAs/genetics; MicroRNAs/metabolism; Oxidative Stress/physiology; Epigenesis, Genetic; Lupus Erythematosus, Systemic; Oxidative Stress; Biochemistry, Genetics and Molecular Biology (all); Clinical Biochemistry; Biochemistry (medical)

Abstract :

[en] The pathogenesis of systemic lupus erythematosus (SLE) is influenced by both genetic factors and epigenetic modifications; the latter is a result of exposure to various environmental factors. Epigenetic modifications affect gene expression and alter cellular functions without modifying the genomic sequences. CpG-DNA methylation, histone modifications, and miRNAs are the main epigenetic factors of gene regulation. In SLE, global and gene-specific DNA methylation changes have been demonstrated to occur in CD4+ T-cells. Moreover, histone acetylation and deacetylation inhibitors reverse the expression of multiple genes involved in SLE, indicating histone modification in SLE. Autoreactive T-cells and B-cells have been shown to alter the patterns of epigenetic changes in SLE patients. Understanding the molecular mechanisms involved in the pathogenesis of SLE is critical for the introduction of effective, target-directed and tolerated therapies. In this review, we summarize the recent findings that highlight the importance of epigenetic modifications and their mechanisms in SLE.

Disciplines :

Genetics & genetic processes

Author, co-author :

Farivar, Shirin ; Dept. of Molecular and Cell Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University G.C. Tehran, Iran

Shaabanpouraghamaleki, Fateme ; Université de Liège - ULiège > Faculté des Sciences > Form. doct. sc. (bioch., biol. mol. cel., bioinf. - paysage) ; Dept. of Molecular and Cell Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University G.C. Tehran, Iran

Language :

English

Title :

Effects of Major Epigenetic Factors on Systemic Lupus Erythematosus.

Publication date :

September 2018

Journal title :

Iranian Biomedical Journal

ISSN :

1028-852X

Publisher :

Pasteur Institute of Iran, Iran

Volume :

Issue :

Pages :

294 - 302

Peer reviewed :

Editorial reviewed

Additional URL :

http://ibj.pasteur.ac.ir/article-1-2427-en.pdf

Available on ORBi :

since 29 April 2024

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