[en] [en] BACKGROUND: The purpose of this study was to compare 3-year overall survival after simultaneous portal (PVE) and hepatic vein (HVE) embolization versus PVE alone in patients undergoing liver resection for primary and secondary cancers of the liver.
METHODS: In this multicentre retrospective study, all DRAGON 0 centres provided 3-year follow-up data for all patients who had PVE/HVE or PVE, and were included in DRAGON 0 between 2016 and 2019. Kaplan-Meier analysis was undertaken to assess 3-year overall and recurrence/progression-free survival. Factors affecting survival were evaluated using univariable and multivariable Cox regression analyses.
RESULTS: In total, 199 patients were included from 7 centres, of whom 39 underwent PVE/HVE and 160 PVE alone. Groups differed in median age (P = 0.008). As reported previously, PVE/HVE resulted in a significantly higher resection rate than PVE alone (92 versus 68%; P = 0.007). Three-year overall survival was significantly higher in the PVE/HVE group (median survival not reached after 36 months versus 20 months after PVE; P = 0.004). Univariable and multivariable analyses identified PVE/HVE as an independent predictor of survival (univariable HR 0.46, 95% c.i. 0.27 to 0.76; P = 0.003).
CONCLUSION: Overall survival after PVE/HVE is substantially longer than that after PVE alone in patients with primary and secondary liver tumours.
Disciplines :
Surgery Radiology, nuclear medicine & imaging
Author, co-author :
Korenblik, Remon ; GROW-School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands ; Department of Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands
Heil, Jan; Institute of Physiology, University of Zurich, Zurich, Switzerland ; Department of General, Visceral and Transplant Surgery, University Hospital Frankfurt, Goethe-University Frankfurt, Frankfurt, Germany
Smits, Jens; GROW-School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands ; Department of Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands
James, Sinead; GROW-School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands ; Department of Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands
Olij, Bram; GROW-School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands ; Department of Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands
Bechstein, Wolf O; Department of General, Visceral and Transplant Surgery, University Hospital Frankfurt, Goethe-University Frankfurt, Frankfurt, Germany
Bemelmans, Marc H A; Department of Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands ; Department of General, Visceral and Transplant Surgery, University Hospital Aachen, Aachen, Germany
Binkert, Christoph A; Department of Radiology, Cantonal Hospital Winterthur, Winterthur, Switzerland
Breitenstein, Stefan; Department of General and Visceral Surgery, Cantonal Hospital Winterthur, Winterthur, Switzerland
Williams, Michael; Department of Surgery, Rush University Medical Center Chicago, Chicago, Illinois, USA
Detry, Olivier ; Université de Liège - ULiège > Département des sciences cliniques > Pathologie chirurgicale abdominale et endocrinienne
Dewulf, Maxime J L; Department of Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands ; Department of General, Visceral and Transplant Surgery, University Hospital Aachen, Aachen, Germany
Dili, Alexandra; Department of Abdominal Surgery, CHU-UC Louvain-Namur, Yvoir, Belgium
Grochola, Lukasz F ; Department of General and Visceral Surgery, Cantonal Hospital Winterthur, Winterthur, Switzerland
Grote, Jon; Department of General, Visceral and Transplant Surgery, University Hospital Aachen, Aachen, Germany
Heise, Daniel; Department of General, Visceral and Transplant Surgery, University Hospital Aachen, Aachen, Germany ; Department of General, Visceral and Transplant Surgery, University Hospital Essen, Essen, Germany
Kalil, Jennifer A; Department of Surgery, Section of Hepato-pancreatico-biliary Surgery, McGill University Health Centre, Montreal, Québec, Canada
Metrakos, Peter; Department of Surgery, Section of Hepato-pancreatico-biliary Surgery, McGill University Health Centre, Montreal, Québec, Canada
Neumann, Ulf P; Department of Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands ; Department of General, Visceral and Transplant Surgery, University Hospital Aachen, Aachen, Germany ; Department of General, Visceral and Transplant Surgery, University Hospital Essen, Essen, Germany
Pappas, Sam G; Department of Surgery, Rush University Medical Center Chicago, Chicago, Illinois, USA
Pennetta, Francesca; GROW-School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands ; Department of Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands
Schnitzbauer, Andreas A; Department of General, Visceral and Transplant Surgery, University Hospital Frankfurt, Goethe-University Frankfurt, Frankfurt, Germany
Tasse, Jordan C; Department of Radiology, Rush University Medical Center Chicago, Chicago, Illinois, USA
Winkens, Bjorn; Department of Methodology and Statistics, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, the Netherlands
Olde Damink, Steven W M; Department of Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands ; Department of General, Visceral and Transplant Surgery, University Hospital Aachen, Aachen, Germany ; NUTRIM-School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands
van der Leij, Christiaan; GROW-School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands ; Department of Radiology, Maastricht University Medical Centre, Maastricht, the Netherlands
Schadde, Erik; Institute of Physiology, University of Zurich, Zurich, Switzerland ; Department of Surgery, Rush University Medical Center Chicago, Chicago, Illinois, USA ; Surgical Centre, Hirslanden Clinic Zurich, Zurich, Switzerland ; Switzerland Surgical Centre, Hirslanden Clinic St Anna Luzern, Luzern, Switzerland
van Dam, Ronald M ; GROW-School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands ; Department of Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands ; Department of General, Visceral and Transplant Surgery, University Hospital Aachen, Aachen, Germany
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