Functional connectivity-hemodynamic (un)coupling changes in chronic mild brain injury are associated with mental health and neurocognitive indices: a resting state fMRI study.
ICC; Neurovascular (un)coupling; Rs-fMRI; TSA; mTBI; Radiology, Nuclear Medicine and Imaging; Neurology (clinical); Cardiology and Cardiovascular Medicine
Abstract :
[en] PURPOSE: To examine hemodynamic and functional connectivity alterations and their association with neurocognitive and mental health indices in patients with chronic mild traumatic brain injury (mTBI).
METHODS: Resting-state functional MRI (rs-fMRI) and neuropsychological assessment of 37 patients with chronic mTBI were performed. Intrinsic connectivity contrast (ICC) and time-shift analysis (TSA) of the rs-fMRI data allowed the assessment of regional hemodynamic and functional connectivity disturbances and their coupling (or uncoupling). Thirty-nine healthy age- and gender-matched participants were also examined.
RESULTS: Patients with chronic mTBI displayed hypoconnectivity in bilateral hippocampi and parahippocampal gyri and increased connectivity in parietal areas (right angular gyrus and left superior parietal lobule (SPL)). Slower perfusion (hemodynamic lag) in the left anterior hippocampus was associated with higher self-reported symptoms of depression (r = - 0.53, p = .0006) and anxiety (r = - 0.484, p = .002), while faster perfusion (hemodynamic lead) in the left SPL was associated with lower semantic fluency (r = - 0.474, p = .002). Finally, functional coupling (high connectivity and hemodynamic lead) in the right anterior cingulate cortex (ACC)) was associated with lower performance on attention and visuomotor coordination (r = - 0.50, p = .001), while dysfunctional coupling (low connectivity and hemodynamic lag) in the left ventral posterior cingulate cortex (PCC) and right SPL was associated with lower scores on immediate passage memory (r = - 0.52, p = .001; r = - 0.53, p = .0006, respectively). Uncoupling in the right extrastriate visual cortex and posterior middle temporal gyrus was negatively associated with cognitive flexibility (r = - 0.50, p = .001).
CONCLUSION: Hemodynamic and functional connectivity differences, indicating neurovascular (un)coupling, may be linked to mental health and neurocognitive indices in patients with chronic mTBI.
Disciplines :
Neurosciences & behavior
Author, co-author :
Kagialis, Antonios; Department of Psychiatry, School of Medicine, University of Crete, University Hospital of Heraklion, Crete, Greece ; Department of Radiology, School of Medicine, University of Crete, University Hospital of Heraklion, 71003, Crete, Greece
Simos, Nikolaos-Ioannis ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Manolitsi, Katina; Department of Neurosurgery, School of Medicine, University of Crete, University Hospital of Heraklion, Crete, Greece
Vakis, Antonios; Department of Neurosurgery, School of Medicine, University of Crete, University Hospital of Heraklion, Crete, Greece
Simos, Panagiotis; Department of Psychiatry, School of Medicine, University of Crete, University Hospital of Heraklion, Crete, Greece ; Institute of Computer Science, Foundation for Research and Technology - Hellas, Heraklion, Crete, Greece
Papadaki, Efrosini ; Department of Radiology, School of Medicine, University of Crete, University Hospital of Heraklion, 71003, Crete, Greece. fpapada@otenet.gr ; Institute of Computer Science, Foundation for Research and Technology - Hellas, Heraklion, Crete, Greece. fpapada@otenet.gr
Language :
English
Title :
Functional connectivity-hemodynamic (un)coupling changes in chronic mild brain injury are associated with mental health and neurocognitive indices: a resting state fMRI study.
Publication date :
12 April 2024
Journal title :
Neuroradiology
ISSN :
0028-3940
eISSN :
1432-1920
Publisher :
Springer Science and Business Media Deutschland GmbH, Germany
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