Distinct hemodynamic and functional connectivity features of fatigue in clinically isolated syndrome and multiple sclerosis: accounting for the confounding effect of concurrent depression symptoms.
Clinically isolated syndrome; Depression; Fatigue; Relapsing–remitting multiple sclerosis; Resting-state fMRI; Time shift analysis; Humans; Depression/diagnostic imaging; Brain/diagnostic imaging; Magnetic Resonance Imaging; Multiple Sclerosis/complications; Multiple Sclerosis/diagnostic imaging; Multiple Sclerosis, Relapsing-Remitting; Brain; Multiple Sclerosis; Radiology, Nuclear Medicine and Imaging; Neurology (clinical); Cardiology and Cardiovascular Medicine
Abstract :
[en] PURPOSE: This study aims to identify common and distinct hemodynamic and functional connectivity (FC) features for self-rated fatigue and depression symptoms in patients with clinically isolated syndrome (CIS) and relapsing-remitting multiple sclerosis (RR-MS).
METHODS: Twenty-four CIS, 29 RR-MS patients, and 39 healthy volunteers were examined using resting-state fMRI (rs-fMRI) to obtain whole-brain maps of (i) hemodynamic response patterns (through time shift analysis), (ii) FC (via intrinsic connectivity contrast maps), and (iii) coupling between hemodynamic response patterns and FC. Each regional map was correlated with fatigue scores, controlling for depression, and with depression scores, controlling for fatigue.
RESULTS: In CIS patients, the severity of fatigue was associated with accelerated hemodynamic response in the insula, hyperconnectivity of the superior frontal gyrus, and evidence of reduced hemodynamics-FC coupling in the left amygdala. In contrast, depression severity was associated with accelerated hemodynamic response in the right limbic temporal pole, hypoconnectivity of the anterior cingulate gyrus, and increased hemodynamics-FC coupling in the left amygdala. In RR-MS patients, fatigue was associated with accelerated hemodynamic response in the insula and medial superior frontal cortex, increased functional role of the left amygdala, and hypoconnectivity of the dorsal orbitofrontal cortex, while depression symptom severity was linked to delayed hemodynamic response in the medial superior frontal gyrus; hypoconnectivity of the insula, ventromedial thalamus, dorsolateral prefrontal cortex, and posterior cingulate; and decreased hemodynamics-FC coupling of the medial orbitofrontal cortex.
CONCLUSION: There are distinct FC and hemodynamic responses, as well as different magnitude and topography of hemodynamic connectivity coupling, associated with fatigue and depression in early and later stages of MS.
Disciplines :
Neurosciences & behavior
Author, co-author :
Antypa, Despina; Department of Psychiatry, School of Medicine, University of Crete, University Hospital of Heraklion, Crete, Greece
Simos, Nikolaos-Ioannis ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Panou, Theodora; Department of Psychiatry, School of Medicine, University of Crete, University Hospital of Heraklion, Crete, Greece
Spyridaki, Eirini; Department of Psychiatry, School of Medicine, University of Crete, University Hospital of Heraklion, Crete, Greece
Kagialis, Antonios; Department of Psychiatry, School of Medicine, University of Crete, University Hospital of Heraklion, Crete, Greece
Kosteletou, Emmanouela; Institute of Applied Mathematics, Foundation for Research and Technology, Hellas, Heraklion, Crete, Greece
Kavroulakis, Eleftherios; Department of Radiology, School of Medicine, University of Crete, University Hospital of Heraklion, Crete, Greece
Mastorodemos, Vasileios; Department of Neurology, School of Medicine, University of Crete, University Hospital of Heraklion, Crete, Greece
Papadaki, Efrosini ; Computational Bio-Medicine Laboratory, Institute of Computer Science, Foundation for Research and Technology, Hellas, Heraklion, Crete, Greece. fpapada@otenet.gr ; Department of Radiology, School of Medicine, University of Crete, University Hospital of Heraklion, Crete, Greece. fpapada@otenet.gr
Language :
English
Title :
Distinct hemodynamic and functional connectivity features of fatigue in clinically isolated syndrome and multiple sclerosis: accounting for the confounding effect of concurrent depression symptoms.
Publication date :
August 2023
Journal title :
Neuroradiology
ISSN :
0028-3940
eISSN :
1432-1920
Publisher :
Springer Science and Business Media Deutschland GmbH, Germany
This manuscript has been partially published as an abstract: Neuroradiology (2022) 64 (Suppl 1 ):S1–S165 https://doi.org/10.1007/s00234-022-03012-w. Abstracts ESNR 2022 Published online: 8 August 2022. p. 535: 1-O20 Distinct resting-state fmri features of fatigue in clinically isolated syndrome and multiple sclerosis: accounting for the confounding effect of concurrent depression symptoms.
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