[en] We describe the molecular cloning of two novel human and murine transcription factors containing the TEA/ATTS DNA binding domain and related to transcriptional enhancer factor-1 (TEF-1). These factors bind to the consensus TEA/ATTS cognate binding site exemplified by the GT-IIC and Sph enhansons of the SV40 enhancer but differ in their ability to bind cooperatively to tandemly repeated sites. The human TEFs are differentially expressed in cultured cell lines and the mouse (m)TEFs are differentially expressed in embryonic and extra-embryonic tissues in early post-implantation embryos. Strikingly, at later stages of embryogenesis, mTEF-3 is specifically expressed in skeletal muscle precursors, whereas mTEF-1 is expressed not only in developing skeletal muscle but also in the myocardium. Together with previous data, these results point to important, partially redundant, roles for these TEF proteins in myogenesis and cardiogenesis. In addition, mTEF-1 is strongly coexpressed with mTEF-4 in mitotic neuroblasts, while accentuated mTEF-4 expression is also observed in the gut and the nephrogenic region of the kidney. These observations suggest additional roles for the TEF proteins in central nervous system development and organogenesis.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Jacquemin, Patrick
Hwang, Jung-Joo
Martial, Joseph ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Dolle, Pascal
Davidson, Irwin
Language :
English
Title :
A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain
Publication date :
1996
Journal title :
Journal of Biological Chemistry
ISSN :
0021-9258
eISSN :
1083-351X
Publisher :
American Society for Biochemistry and Molecular Biology, Baltimore, United States - Maryland
Davidson, I., Xiao, J. H., Rosales, R., Staub, A., and Chambon, P. (1988) Cell 54, 931-942
Xiao, J. H., Davidson, I., Matthes, H., Garnier, J.-M., and Chambon, P. (1991) Cell 65, 551-568
Andrianopoulos, A., and Timberlake, W. E. (1991) Plant Cell 3, 747-748
Bürglin, T. R. (1991) Cell. 66, 11-12
Laloux, I., Dubois, E., Dewerchin, M., and Jacobs, E. (1990) Mol. Cell. Biol. 10, 3541-3550
Laloux, I., Jacobs, E., and Dubois, E. (1994) Nucleic Acids Res. 22, 999-1005
Mirabito, P. M., Adams, T. H., and Timberlake, W. E. (1989) Cell 57, 859-868
Andrianopoulos, A., and Timberlake, W. E. (1994) Mol. Cell. Biol. 14, 2503-2515
Campbell, S., Inamdar, M., Rodrigues, V., Raghavan, V., Palazzolo, M., and Chovnick, A. (1992) Genes Dev. 6, 367-379
Inamdar, M., Vijayraghavan, K., and Rodrigues, V. (1993) J. Neurogenet. 9, 123-139
Yasunami, M., Suzuki, K., Houtami, T., Sugimoto, T., and Ohkubo, H. (1995) J. Biol. Chem. 270, 18649-18654
Xiao, J. H., Davidson, I., Ferrandon, D., Resales, R., Vigneron, M. Macchi, M., Ruffenach, F., and Chambon, P. (1987) EMBO J. 6, 3005-3013
Hwang, J. J., Chambon, P., and Davidson, I. (1993) EMBO J. 12, 2337-2348
Fromental, C., Kanno, M., Nomiyama, H., and Chambon P. (1988) Cell 54, 943-953
Ondek, B., Gloss, L., and Herr, W. (1988) Nature 333, 40-45
Gruda, M. C., and Alwine, J. C. (1991) J. Virol. 65, 3553-3558
Casaz, P., Sundseth, R., and Hansen, U. (1991) J. Virol. 65, 6535-6543
Kelly, J. J., and Wildeman, A. (1991) Nucleic Acids Res. 19, 6799-6804
Gruda, M. C., Zabolotny, J. M., Xiao, J. H., Davidson, I., and Alwine, J. C. (1993) Mol. Cell. Biol. 13, 961-969
Berger, L. C., Smith, D. B., Davidson, I., Hwang, J. J., Fanning, E., and Wildeman, A. G. (1996) J. Virol. 70, 1203-1212
Ishiji, T., Lace, M. J., Parkkinen, S., Anderson, R. D., Haugen, T. H., Cripe, T. P., Xiao, J. H., Davidson, I., Chambon, P., and Turek, L. P. (1992) EMBO J. 6, 2271-2281
Brou, C., Chaudhary, S., Davidson, I., Lutz, Y., Wu, J., Egly, J. M., Tora, L., and Chambon, P. (1993) EMBO J. 12, 489-499
Chaudhary, S., Brou, C., Valentin, M. E., Burton, N., Tora, L., Chambon, P., and Davidson, I. (1994) Mol. Cell. Biol. 14, 5290-5299
Chaudhary, S., Tora, L., and Davidson, I. (1995) J. Biol. Chem. 270, 3631-3637
Mar, J. H., and Ordahl, C. P. (1990) Mol. Cell. Biol. 10, 4271-4283
Farrance, I. K. G., Mar, J. H., and Ordahl, C. P. (1992) J. Biol. Chem. 267, 17234-17240
Shimizu, N., Dizon, E., and Zak, R. (1992) Mol. Cell. Biol. 12, 619-630
Shimizu, N., Smith, G., and Izumo, S. (1993) Nucleic Acids Res 21, 4103-4110
Flink, I. L., Edwards, J. G., Bahl, J. J., Liew, C. C., Sole, M., and Morkin, E. (1992) J. Biol. Chem. 267, 1513-1522
Molkentin, J. D., and Markham, B. E. (1994) Mol. Cell. Biol. 14, 5056-5065
Knotts, S., Rindt, H., Neumann, J., and Robbins, J. (1994) J. Biol. Chem. 269, 31275-31282
Stewart, A. F. R., Larkin, S. B., Farrance, I. K. G., Mar, J. H., Hall, D. E., and Ordahl, C. P. (1994) J. Biol. Chem. 269, 3147-3150
Sun, S., Stoflet, E. S., Cogan, J. G., Strauch, A. R., and Getz, M. J. (1995) Mol. Cell. Biol. 15, 2429-2436
Kariya, K., Farrance, I. K. G., and Simpson, P. C. (1993) J. Biol. Chem. 268, 26658-26662
Gupta, M. P., Gupta, M., and Zak, R. (1994) J. Biol. Chem. 269, 29677-29687
MacLellan, W. R., Lee, T.-C., Schwartz, R. J., and Schneider, M. D. (1994) J. Biol. Chem. 269, 16754-16760
Karns, L. R., Kariya, K., and Simpson, P. C. (1995) J. Biol. Chem. 270, 410-417
Chen, Z., Friedrich, G. A., and Soriano, P. (1994) Genes Dev. 8, 2293-2301
Walker, W. H., Fitzpatrick, S. L., and Saunders, G. F. (1990) J. Biol. Chem. 265, 12940-12948
Jacquemin, P., Oury, C., Peers, B., Morin, A., Belayew, A., and Martial, J. A. (1994) Mol. Cell. Biol. 14, 93-103
Jacquemin, P., Oury, C., Belayew, A., Martial, J. A. (1994) DNA Cell Biol. 13, 1037-1045
Lytras, A., and Cattini, P. A. (1994) Mol. Endocrinol. 8, 478-489
Jiang, S.-W., and Eberhardt, N. L. (1994) J. Biol. Chem. 269, 10384-10392
Jiang, S.-W., and Eberhardt, N. L. (1995) J. Biol. Chem. 270, 13906-13915
Mengus, G., May, M., Jacq, X., Staub, A., Tora, L., Chambon, P., and Davidson, I. (1995) EMBO J. 14, 1520-1531
May, M., Mengus, G., Lavigne, A. C., Chambon, P., and Davidson, I. (1996) EMBO J. 15, 3093-3104
Shpakovski, G. G., Acker, J., Wintzerith, M., Lacroix, J. F., Thuriau, P., and Vigneron, M. (1995) Mol. Cell. Biol. 15, 4702-4710
Décimo, D., Georges-Labouesse, E., and Dollé, P. (1995) in Gene Probes: A Practical Approach (Higgins, S. J., and Hames, B. D., eds) Vol. 2, pp. 183-210, Oxford University Press, Oxford
Crossley, M., Whitelaw, E., Perkins, A., Williams, G., Fujiwara, Y., and Orkin, S. H. (1996) Mol. Cell. Biol. 16, 1695-1705
Blatt, C., and DePamphilis, M. M. (1993) Nucleic Acids Res. 21, 747-748
Rosales, R., Vigneron, M., Macchi, M., Davidson, I., Xiao, J. H., and Chambon, P. (1987) EMBO J. 6, 3015-3025
Azakie, A., Larkin, S. B., Farrance, I. K., Grenningloh, G., and Ordahl, C. P. (1996) J. Biol. Chem. 271, 8260-8265
Wasylyk, C., Kerckaert, J. P., and Wasylyk, B. (1992) Genes Dev. 6, 965-974
Petersen, J. M., Skalicky, J. J., Donaldson, L. W., McIntosh, L. P., Alber, T., and Graves, B. J. (1995) Science 269, 1866-1869
Rossant, J. (1995) Semin. Dev. Biol. 6, 237-247
Nomiyama, H., Fromental, C., Xiao, J. H., and Chambon, P. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 7881-7885
Mélin, F., Miranda, M., Montreau, N., DePamphilis, M. L., and Blangy, D. (1993) EMBO J. 12, 4657-4666
Nothias, J.-Y., Majumder, S., Kaneko, K. J., and DePamphilis, M. L. (1995) J. Biol. Chem. 270, 22077-22080
Ordahl, C. P., and LeDouarin, N. M. (1992) Development 114, 339-353
Weintraub, H. (1993) Cell 75, 1241-1244
Buckingham, M. E. (1994) Curr. Opin. Genet. Dev. 4, 745-751
Farrance, I. K. G., and Ordahl, C. P. (1996) J. Biol. Chem. 271, 8266-8274
Olson, E. N., Perry, M., and Schulz, R. A. (1995) Dev. Biol. 172, 2-14
Rudnicki, M. A., Schnegelsberg, P. N. J., Stead, R. H., Braun, T., Arnold, H.-H., and Jaenisch, R. (1993) Cell 75, 1351-1359
Dodou, E., Sparrow, D. B., Mohun, T., and Treisman, R. (1995) Nucleic Acids Res. 23, 4267-4274
Molkentin, J. D., Black, B. L., Martin, J. F., and Olson, E. N. (1995) Cell 83, 1125-1136