Anomalous self-experiences and neurocognitive functioning in adolescents at risk for psychosis: Still no significant associations found between these two vulnerability markers.
Anomalous self-experiences; At-risk for psychosis; Neurocognitive functioning; Norwegian Mother, Father and Child Cohort Study; adolescence; Female; Child; Humans; Adolescent; Male; Cohort Studies; Psychopathology; Regression Analysis; Risk Factors; Psychotic Disorders/diagnosis; Psychotic Disorders/psychology; Psychotic Disorders; Clinical Psychology; Psychiatry and Mental Health
Abstract :
[en] [en] BACKGROUND: Anomalous self-experiences (ASEs) and neurocognitive impairments are considered essential domains of vulnerability for developing psychotic disorders. However, little research exists of possible associations between ASEs and neurocognitive functions in individuals at-risk for psychosis. The interconnections between ASEs and neurocognitive impairments should therefore be clarified as much as possible, especially in young individuals at risk. No previous studies have investigated these two fundamental domains in non-help-seeking adolescents at risk for developing psychosis.
METHODS: This study is based on the Norwegian Mother, Father and Child Cohort Study (MoBa). Adolescents (N = 48, 94% females, mean age = 15.3) were invited to participate after completing a 14-year-old survey distributed by MoBA. At-risk adolescents were selected based on the 0.4% highest scores on 19 items assessing both psychotic-like experiences and ASEs. Five specifically selected and formulated items measuring ASEs were computed to an ASEs total score. Neurocognitive functioning was assessed using the MATRICS Consensus Cognitive Battery.
RESULTS: Regression analyses revealed no significant relationships between ASEs and any neurocognitive domain.
CONCLUSIONS: We did not find any significant associations between ASEs and neurocognitive functions in non-help-seeking adolescents at risk for psychotic disorders, which is in line with reports from other types of cohorts. Thus, ASEs and neurocognitive functions may be understood as two relatively separate domains that co-exist in at-risk states. These results underline the need for a wider scope when making predictions about future trajectories, e.g. the development of psychotic disorders. Including both ASEs and neurocognitive functioning in at-risk populations may increase the specificity of vulnerability criteria in this population and enhance our understanding of early psychosis psychopathology.
Disciplines :
Neurosciences & behavior
Author, co-author :
Mohn-Haugen, Caroline Ranem; Research Department, Vestre Viken Hospital Trust, 3004 Drammen, Norway, Department of Psychology, P. O. Box 1094 Blindern, University of Oslo, 0317, Oslo, Norway. Electronic address: c.r.mohn-haugen@psykologi.uio.no
Møller, Paul; Department of Mental Health Research and Development, Division of Mental Health and Addiction, Vestre Viken Hospital Trust, 3004 Drammen, Norway
Mohn, Christine; Norment Centre, Institute of Clinical Medicine, University of Oslo, P. O. Box 4956 Nydalen, 0424 Oslo, Norway
Laroi, Frank ; Université de Liège - ULiège > Département de Psychologie
Teigset, Charlotte M; Research Department, Vestre Viken Hospital Trust, 3004 Drammen, Norway
Øie, Merete Glenne; Department of Psychology, P. O. Box 1094 Blindern, University of Oslo, 0317, Oslo, Norway
Rund, Bjørn Rishovd; Research Department, Vestre Viken Hospital Trust, 3004 Drammen, Norway, Department of Psychology, P. O. Box 1094 Blindern, University of Oslo, 0317, Oslo, Norway
Language :
English
Title :
Anomalous self-experiences and neurocognitive functioning in adolescents at risk for psychosis: Still no significant associations found between these two vulnerability markers.
The Norwegian Mother, Father and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research . We are grateful to all the participating families in Norway who take part in this on-going cohort study. This work was supported by grants from Vestre Viken Hospital Trust (# 96G002 ) and South- Eastern Norway Regional Health Authority : (# 2013061 ) to Dr. Rund. We would like to thank Cathrine Brunborg for advice on statistics.
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