heterosis; overdominant model of inheritance; sheep; Animal Science and Zoology; Veterinary (all); General Veterinary
Abstract :
[en] Negative heterosis can occur on different economically important traits, but the exact biological mechanisms of this phenomenon are still unknown. The present study focuses on determining the genetic factors associated with negative heterosis in interspecific hybrids between domestic sheep (Ovis aries) and argali (Ovis ammon). One locus (rs417431015) associated with viability and two loci (rs413302370, rs402808951) associated with meat productivity were identified. One gene (ARAP2) was prioritized for viability and three for meat productivity (PDE2A, ARAP1, and PCDH15). The loci associated with meat productivity were demonstrated to fit the overdominant inheritance model and could potentially be involved int negative heterosis mechanisms.
Disciplines :
Genetics & genetic processes
Author, co-author :
Zlobin, Alexander ; Université de Liège - ULiège > GIGA > GIGA Medical Genomics - Unit of Animal Genomics ; Kurchatov Genomic Center, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences SB RAS, 630090 Novosibirsk, Russia
Volkova, Natalia A ; L.K. Ernst Federal Science Center for Animal Husbandry, 101000 Moscow, Russia
Zinovieva, Natalia A ; L.K. Ernst Federal Science Center for Animal Husbandry, 101000 Moscow, Russia
Iolchiev, Baylar S ; L.K. Ernst Federal Science Center for Animal Husbandry, 101000 Moscow, Russia
Bagirov, Vugar A; L.K. Ernst Federal Science Center for Animal Husbandry, 101000 Moscow, Russia
Borodin, Pavel M ; Institute of Cytology and Genetics, SB RAS, 630090 Novosibirsk, Russia
Axenovich, Tatiana I; Institute of Cytology and Genetics, SB RAS, 630090 Novosibirsk, Russia
Tsepilov, Yakov A ; Kurchatov Genomic Center, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences SB RAS, 630090 Novosibirsk, Russia
Language :
English
Title :
Loci Associated with Negative Heterosis for Viability and Meat Productivity in Interspecific Sheep Hybrids.
The work of Y.A.T. was supported by the Kurchatov Genomics Center of IC&G (075-15-2019-1662). The work of T.I.A. was supported by the budget project № FWNR-2022-0020. The work of A.S.Z. was supported by the budget project № FWNR-2022-0004.
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