[en] Despite their economic value, sheep remain relatively poorly studied animals in terms of the number of known loci and genes associated with commercially important traits. This gap in our knowledge can be filled in by performing new genome-wide association studies (GWAS) or by re-analyzing previously documented data using novel powerful statistical methods. This study is focused on the search for new loci associated with meat productivity and carcass traits in sheep. With a multivariate approach applied to publicly available GWAS results, we identified eight novel loci associated with the meat productivity and carcass traits in sheep. Using an in silico follow-up approach, we prioritized 13 genes in these loci. One of eight novel loci near the FAM3C and WNT16 genes has been replicated in an independent sample of Russian sheep populations (N = 108). The novel loci were added to our regularly updated database increasing the number of known loci to more than 140.
Disciplines :
Genetics & genetic processes
Author, co-author :
Zlobin, Alexander ; Université de Liège - ULiège > GIGA > GIGA Medical Genomics - Unit of Animal Genomics ; Kurchatov Genomics Center of IC&G, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia
Nikulin, Pavel S; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia
Volkova, Natalia A ; L.K. Ernst Federal Research Center for Animal Husbandry, Dubrovitsy, 142132 Moscow Region, Russia
Zinovieva, Natalia A ; L.K. Ernst Federal Research Center for Animal Husbandry, Dubrovitsy, 142132 Moscow Region, Russia
Iolchiev, Baylar S ; L.K. Ernst Federal Research Center for Animal Husbandry, Dubrovitsy, 142132 Moscow Region, Russia
Bagirov, Vugar A; L.K. Ernst Federal Research Center for Animal Husbandry, Dubrovitsy, 142132 Moscow Region, Russia
Borodin, Pavel M ; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia ; L.K. Ernst Federal Research Center for Animal Husbandry, Dubrovitsy, 142132 Moscow Region, Russia ; Department of Natural Science, Novosibirsk State University, 630090 Novosibirsk, Russia
Aksenovich, Tatiana I; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia ; L.K. Ernst Federal Research Center for Animal Husbandry, Dubrovitsy, 142132 Moscow Region, Russia ; Department of Natural Science, Novosibirsk State University, 630090 Novosibirsk, Russia
Tsepilov, Yakov A ; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia ; L.K. Ernst Federal Research Center for Animal Husbandry, Dubrovitsy, 142132 Moscow Region, Russia ; Department of Natural Science, Novosibirsk State University, 630090 Novosibirsk, Russia
Language :
English
Title :
Multivariate Analysis Identifies Eight Novel Loci Associated with Meat Productivity Traits in Sheep.
The work of Y.A.T., P.M.B., T.I.A., and N.A.V. was supported by Russian Science Foundation #18‐16‐00079. The work of A.S.Z. was supported by the Kurchatov Genomics Center of IC&G (075‐15‐2019‐1662). The work of N.A.Z., V.A.B., and B.S.I. was supported by the Ministry of Science and Higher Education of the Russian Federation (theme No. 0445‐2021‐0005).Funding: The work of Y.A.T., P.M.B., T.I.A., and N.A.V. was supported by Russian Science Foun‐ dation #18‐16‐00079. The work of A.S.Z. was supported by the Kurchatov Genomics Center of IC&G (075‐15‐2019‐1662). The work of N.A.Z., V.A.B., and B.S.I. was supported by the Ministry of Science and Higher Education of the Russian Federation (theme No. 0445‐2021‐0005).
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