[en] [en] BACKGROUND: The Schwartz equation is the most widely used serum creatinine (SCr)-based formula to estimate the glomerular filtration rate (GFR) in children of European descent, but whether this applies to African children is unclear.
METHODS: In a cross-sectional study, 513 apparently healthy African children aged 6 to 16 years were randomly recruited in school area of Kinshasa, the Democratic Republic of Congo (DRC). SCr was measured using calibrated enzymatic method. SCr was normalized using Q-values designed for European descent children, due to the absence of Q-values for African children. Commonly used eGFR equations were applied in this population.
RESULTS: Normalization of SCr using Q-values for European descent children was effective in this cohort. The majority of African children (93.4%) have normalized SCr (SCr/Q) values within the reference interval (0.67-1.33) of children of European descent. The bedside-Schwartz equation was associated with significant age and sex dependency. However, the FAS-Age formula showed no sex and age dependency. The new CKiDU25 equation did not show a significant sex dependency. The recently introduced EKFC and LMR18 equations also showed no age and sex dependency, although the distribution of eGFR-values was not symmetrical. On the other hand, the FAS-Height and the Schwartz-Lyon equations showed significant sex dependency but no age dependency.
CONCLUSIONS: The reference interval for SCr designed for European descent children can be applied to African children. Of all the equations studied, FAS-Age performed best and is most suitable because no height measurements are required. Establishment of specific Q-values for the widespread Jaffe-measured creatinine in Africa can further broaden applicability.
Disciplines :
Urology & nephrology Laboratory medicine & medical technology
Author, co-author :
Nkoy, Agathe Bikupe ; Division of Nephrology, Department of Pediatrics, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo. agath.nkoy@gmail.com ; Laboratory of Pediatric Nephrology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. agath.nkoy@gmail.com
Matoka, Therance Tobo; Division of Nephrology, Department of Pediatrics, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo
Bukabau, Justine Busanga ; Division of Nephrology, Department of Internal Medicine, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo
Sumaili, Ernest Kiswaya ; Division of Nephrology, Department of Internal Medicine, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo
Labarque, Veerle ; Department of Pediatric Hematology, University Hospital Leuven, Leuven, Belgium ; Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
van den Heuvel, Lambertus P ; Laboratory of Pediatric Nephrology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium ; Department of Pediatric Nephrology, Radboud University Medical Centre, Nijmegen, Netherlands
Levtchenko, Elena ; Laboratory of Pediatric Nephrology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium ; Department of Pediatric Nephrology, Amsterdam University Medical Centre, Amsterdam, The Netherlands
Cavalier, Etienne ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Delanaye, Pierre ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale ; Department of Nephrology-Dialysis-Apheresis, Hôpital Universitaire Carémeau, Nîmes, France
Ekulu, Pépé Mfutu ; Division of Nephrology, Department of Pediatrics, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo
Pottel, Hans ; Université de Liège - ULiège > Département des sciences cliniques ; Department of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium
Language :
English
Title :
Estimated glomerular filtration rate: applicability of creatinine-based equations in African children.
Publication date :
28 March 2024
Journal title :
Pediatric Nephrology
ISSN :
0931-041X
eISSN :
1432-198X
Publisher :
Springer Science and Business Media Deutschland GmbH, Germany
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